Docking Studies, Synthesis, and Evaluation of Antioxidant Activities of N-Alkylated, 1,2,4-Triazole, 1,3,4-Oxa-, and Thiadiazole Containing the Aminopyrazolopyridine Derivatives

Abdel‐Monem, Yasser K.; El‐Essawy, Farag A.; El-Enein, Saeyda A. Abou; El-Sheikh-Amer, Mona M.

doi:10.4236/ijoc.2013.33026

Cited by 15 publications

(7 citation statements)

References 21 publications

(26 reference statements)

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“…Furthermore, the signals of protons of methyl groups attached to pyrane ring and azomethine group appear as sharp singlet at δ 2.15 and 2.68 ppm, respectively. While, the signals of protons of methyl groups attached with pyrazolopyridine moiety observed at δ 2.52–2.56 ppm …”

Section: Resultsmentioning

confidence: 99%

“…Fused heterocyclic systems containing pyrazole and pyridine rings have been attracted considerable attention due to their great usefulness in chemistry and a very wide spectrum of their biological activities. Pyrazolopyridines exhibit antitubercular, antiproliferative, inhibition of cyclin‐dependent kinases and cardio‐vascular antiviral and antileishmanial activities . Pyrazolopyridines specially, pyrazolo[3,4‐ b ]pyridine has proven to be interesting class of heterocycles due to diverse biological properties including antioxidant and antitumor activities .…”

Section: Introductionmentioning

confidence: 99%

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Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4,6‐dimethyl‐1H‐pyrazolo[3,4‐b] pyridin‐3‐yl)imino)ethyl)‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one

Emam

Abouel‐Enein

Abdel‐Satar

2019

Applied Organom Chemis

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A new series of metal complexes containing Co(II), Pd(II), Fe(III) chloride and Cu(II) salts (chloride, bromide, sulphate and perchlorate) have been prepared with Schiff base ligand (HL). The synthesized compounds were elucidated using elemental analyses, spectral techniques, molar conductance, magnetic measurements and thermogravimetric studies. The analytical data established (1 M:1 L) stoichiometry for complexes (1), (2), (4), (6) and (7) as well as (1 M:2 L) and (2 M:3 L) stoichiometry for complexes (5) and (3), respectively. As a result, the ligand HL coordinates in complexes (1), (2), (4), (6) as a monobasic tridentate ONN moiety via the oxygen atom of the deprotonated phenolic OH, the nitrogen atoms of the azomethine and the imine group in pyrazolopyridine ring. While, it behaves as a neutral bidentate in complexes (3,7), chelates via oxygen and nitrogen atoms of enolic OH and azomethine groups. Also, in complex (5) Cu2+ ion binds via NO sits of two ligand molecules in its monobasic and neutral forms. The magnetic moment and electronic spectral data proposed octahedral structure for complexes (2, 3 and 7) as well as triagonal bipyramidal and square pyramidal geometry for complexes (1 and 4), while, chelates (5) and (6) possess square planar geometry. TG/DTG studies confirmed the chemical formula for these complexes and established the thermal decomposition processes ended with the formation of metal or metal oxides contaminated with carbon residue. An axial electron spin resonance spectra were suggested for Cu(II) complexes pointing to 2B1g as a ground state with hyperfine structure for complex (4). In vitro antibacterial and antioxidant activities were performed for HL ligand and its metal complexes. The biological studies indicate that complex (3) has better antibacterial activity compared to the ligand and the other complexes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4,6‐dimethyl‐1H‐pyrazolo[3,4‐b] pyridin‐3‐yl)imino)ethyl)‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one

Emam

Abouel‐Enein

Abdel‐Satar

2019

Applied Organom Chemis

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“…The stretching deformation and bending vibrations modes of C-H of methyl groups were associated with the bands appeared at 2971, 2890, 1407 and 826 cm -1 . The spectrum of L32 gave bands at 3040, 1520, 1023 and 615,579 cm -1 referred to stretching and bending of C-H in-plane of the pyridine ring [29]. The infrared spectra of C32 showed the v(NH 2 ) symmetric and asymmetric, undergo shift towards higher wavenumber by 14-59 and 19-21 cm -1 , respectively relative to L32.…”

Section: Structural Characteristics Of the Compoundsmentioning

confidence: 96%

Chromium Coordination Compounds with Antimicrobial Activity: Synthetic Routes, Structural Characteristics, and Antibacterial Activity

Vlasiou¹,

Pafiti²

2020

TOMCJ

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A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of molecules provide new challenges and seem promising to solve the crisis that the overuse of antibiotics has led over the last years. This review discusses the challenges of chromium-based metallodrugs as antimicrobial agents. In particular, the synthetic routes, the structural characteristics, as well as the antimicrobial activity of 32 chromium (III) complexes have been presented.

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“…Potent antioxidant activity has been reported in 1-( (5-(benzylthio)-1,3,4-oxadiazol-2-yl)methyl)-4,6-di-methyl-1H-pyrazolo[3,4-b] pyridin-3-amine derivatives [31] (Figure 31). …”

Section: Antioxidant Activitymentioning

confidence: 98%

Latest Update on Pharmacological Activities of 1,3,4-Oxadiazole Derivatives

Kumar¹,

Kumar²

2016

J Cell Sci Ther

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Heterocyclic compounds have been an interesting area for the study of synthesis and biological activity of novel oxadiazole derivatives for a long time. Heterocyclic compounds possess diverse biological properties that have led to intense study and research of these compounds. One of these compounds 1,3,4-Oxadiazole is a versatile heterocyclic nucleus is a novel molecule which attract the medicinal chemist to search a new therapeutic molecule. 1,3,4-oxadizole exhibited a wide range of biological activities which includes antimicrobial activity, anti-tubercular, anticonvulsant, antidiabetic, anti-allergic, enzyme inhibitors, anti-HIV activity, antipyretic activity, Immunosuppressive activity, Spasmolytic Activity, antioxidant activity, Anti-Alzheimer's activity cardiovascular acivity, anti-inflammatory, anti-tumor activity, insecticidal activity, CGRP receptor antagonists, anti-anthelmintic activities. Results of various derivatives of different oxadiazole and their substitutions with diverse biological activities are reviewed in present article.

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Docking Studies, Synthesis, and Evaluation of Antioxidant Activities of N-Alkylated, 1,2,4-Triazole, 1,3,4-Oxa-, and Thiadiazole Containing the Aminopyrazolopyridine Derivatives

Cited by 15 publications

References 21 publications

Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4,6‐dimethyl‐1H‐pyrazolo[3,4‐b] pyridin‐3‐yl)imino)ethyl)‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one

Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4,6‐dimethyl‐1H‐pyrazolo[3,4‐b] pyridin‐3‐yl)imino)ethyl)‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one

Chromium Coordination Compounds with Antimicrobial Activity: Synthetic Routes, Structural Characteristics, and Antibacterial Activity

Latest Update on Pharmacological Activities of 1,3,4-Oxadiazole Derivatives

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