Chromium Coordination Compounds with Antimicrobial Activity: Synthetic Routes, Structural Characteristics, and Antibacterial Activity

Abstract

<jats:p>A major threat to public health worldwide is that the antimicrobial activity of the established drugs is constantly reduced due to the resistance that bacteria develop throughout the years. Some transition metal complexes show higher antibacterial activity against several bacteria compared to those of clinically used antibiotics. Novel classes of molecules provide new challenges and seem promising to solve the crisis that the overuse of antibiotics has led over the last years. This review discusses the challenges of chromium-based metallodrugs as antimicrobial agents. In particular, the synthetic routes, the structural characteristics, as well as the antimicrobial activity of 32 chromium (III) complexes have been presented.</jats:p>

Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities

“…Infectious diseases caused by bacteria seriously threaten human health. Although the existing antibiotics are the mainstay to treat bacterial infections, their irrational use leads to the emergence and spread of multidrug resistance, which has caused a dramatic increase in global morbidity and mortality. − Therefore, there is a pressing medical need to develop novel antibacterial agents, among which metallopharmaceuticals may have substantial potential as an alternative therapeutic strategy. − Unlike most antibacterial drugs, which exert their antibacterial effects through a single mechanism, metal complexes play their antibacterial roles in microbes through multiple pathways such as enzyme inhibition, generation of reactive oxygen species, induction of cell cycle arrest, and intracellular biomolecular interaction. − Pd­(II) complex is a suitable candidate for metallopharmaceuticals due to its similar structural and biological properties as platinum, as well as relatively higher solubility along with lower side effects . The biological evaluation of Pd­(II) complexes has been an area of increasing interest. − …”