Abstract:To realize the synergistic anti-tumor effect of chemotherapy and photodynamic therapy, the mono sulfide-modified docetaxel (DTX) prodrugs (DSD) provided by our laboratory and hematoporphyrin (HP) were used to physically prepare co-assembled nanoparticles (DSD/HP NPs) by nano-precipitation. For the first time, this study showed its characteristics,
in vitro
anti-tumor activity, pharmacokinetic behavior in rats,
in vivo
distribution, and pharmacodynamic effects on 4T… Show more
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