Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy

Bagheri, Mohsen; Zandieh, Mohammad Arad; Daryab, Mahshid; Samaei, Seyedeh Setareh; Gholami, Sarah; Rahmanian, Parham; Dezfulian, Sadaf; Eary, Mahsa; Rezaee, Aryan; Rajabi, Romina; Khorrami, Ramin; Salimimoghadam, Shokooh; Hu, Peng; Rashidi, Mohsen; Ardakan, Alireza Khodaei; Ertas, Yavuz Nuri; Hushmandi, Kiavash

doi:10.1016/j.tranon.2023.101838

Cited by 5 publications

(2 citation statements)

References 186 publications

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“…Although there have been advancements in the progress of cancer drugs, it is evident that cytotoxic chemotherapy will remain the fundamental approach to treating cancer. , Nevertheless, the current chemotherapies are associated with nonselective drug delivery, which leads to adverse effects and toxicity that limit their efficacy. , This calls for a fresh approach to treatment and the development of distinct therapeutic methodologies. Innovative biomimetic NPs with multiple functions have been created to improve the effectiveness of chemotherapy drugs and overcome the restrictions. , These versatile nanocarriers possess the ability to transform the treatment of diverse types of cancer by utilizing the strategy of concealing themselves in T cell membrane.…”

Section: Cancer Therapymentioning

confidence: 99%

“… 54 , 55 Nevertheless, the current chemotherapies are associated with nonselective drug delivery, which leads to adverse effects and toxicity that limit their efficacy. 56 , 57 This calls for a fresh approach to treatment and the development of distinct therapeutic methodologies. Innovative biomimetic NPs with multiple functions have been created to improve the effectiveness of chemotherapy drugs and overcome the restrictions.…”

Section: Cancer Therapymentioning

confidence: 99%

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T Cell and Natural Killer Cell Membrane-Camouflaged Nanoparticles for Cancer and Viral Therapies

Ozsoy,

Mohammed,

Jan

et al. 2024

ACS Appl. Bio Mater.

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Extensive research has been conducted on the application of nanoparticles in the treatment of cancer and infectious diseases. Due to their exceptional characteristics and flexible structure, they are classified as highly efficient drug delivery systems, ensuring both safety and targeted delivery. Nevertheless, nanoparticles still encounter obstacles, such as biological instability, absence of selectivity, recognition as unfamiliar elements, and quick elimination, which restrict their remedial capacity. To surmount these drawbacks, biomimetic nanotechnology has been developed that utilizes T cell and natural killer (NK) cell membrane-encased nanoparticles as sophisticated methods of administering drugs. These nanoparticles can extend the duration of drug circulation and avoid immune system clearance. During the membrane extraction and coating procedure, the surface proteins of immunological cells are transferred to the biomimetic nanoparticles. Such proteins present on the surface of cells confer several benefits to nanoparticles, including prolonged circulation, enhanced targeting, controlled release, specific cellular contact, and reduced in vivo toxicity. This review focuses on biomimetic nanosystems that are derived from the membranes of T cells and NK cells and their comprehensive extraction procedure, manufacture, and applications in cancer treatment and viral infections. Furthermore, potential applications, prospects, and existing challenges in their medical implementation are highlighted.

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