Docetaxel-Loaded Solid Lipid Nanoparticles: Preparation, Characterization, In Vitro, and In Vivo Evaluations

Mosallaei, Navid; Jaafari, Mahmoud Reza; Hanafi‐Bojd, Mohammad Yahya; Golmohammadzadeh, Shiva; Malaekeh‐Nikouei, Bizhan

doi:10.1002/jps.23522

Cited by 92 publications

(46 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fluorescence emission from EPI was measured using spectrofluorometer (Shimadzu, Japan) at excitation and emission wavelengths of 488/555 nm. The calibration curve of EPI was prepared using serial dilutions in the tissue and sera extracts of the control mice from 0.04 to 5 µg/mL in acidified isopropanol [30,32,35]. …”

Section: Biodistribution Studymentioning

confidence: 99%

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

Hanafi‐Bojd

Jaafari

Ramezanian

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

Section: Biodistribution Studymentioning

confidence: 99%

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

Hanafi‐Bojd

Jaafari

Ramezanian

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

“…However, low aqueous solubility and poor penetration inside brain due to multi-drug resistance decrease its efficacy and mark DTX as potential candidate for current research (Kemper et al 2004). Many attempts were made to deliver DTX by the use of surfactant mixture (Yin et al 2009), lipids (Mosallaei et al 2013) etc. But these formulations were found to comprise stability problems and high amount of surfactant can further lead to chances of anaphylactic shock.…”

Section: Introductionmentioning

confidence: 99%

p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation

et al. 2015

View full text Add to dashboard Cite

Dendrimers which are discrete nanostructures/nanoparticles are emerging as promising candidates for many nanomedicine applications. Ligandconjugated dendrimer facilitate the delivery of therapeutics in a targeted manner. Small molecules such as p-hydroxyl benzoic acid (pHBA) were found to have high affinity for sigma receptors which are prominent in most parts of central nervous system and tumors. The aim of this study was to synthesize pHBA-dendrimer conjugates as colloidal carrier for site-specific delivery of practically water insoluble drug, docetaxel (DTX) to brain tumors and to determine its targeting efficiency. pHBA, a small molecule ligand was coupled to the surface amine groups of generation 4-PAMAM dendrimer via a carbodiimide reaction and loaded with DTX. The conjugation was confirmed by 1 HNMR and FT-IR spectroscopy. In vitro release of drug from DTXloaded pHBA-conjugated dendrimer was found to be less as compared to unconjugated dendrimers. The prepared drug delivery system exhibited good physico-chemical stability and decrease in hemolytic toxicity. Cell viability and cell uptake studies were performed against U87MG human glioblastoma cells and formulations exerted considerable anticancer effect than plain drug. Conjugation of dendrimer with pHBA significantly enhanced the brain uptake of DTX which was shown by the recovery of a higher percentage of the dose from the brain following administration of pHBA-conjugated dendrimers compared with unconjugated dendrimer or formulation in clinical use (Taxotere Ò ). Therefore, pHBA conjugated dendrimers could be an efficient delivery vehicle for the targeting of anticancer drugs to brain tumors.

show abstract

“…They can be easily synthesized without using organic solvents [ 29 ], are biodegradable and biocompatible, and allow good control of the drug release [ 30 ]. Due to their numerous successful applications, a later chapter of the book (Chap.…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Nanoparticles, Nanomaterials and Nanocarriers

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

View full text Add to dashboard Cite

Nanoparticles have been considered for a while as unlikely to penetrate healthy (undisrupted) skin [ 1 ]. It is universally accepted now that their size is an important factor which determines their absorption into the skin. In 2008 a European forum, the Scientifi c Committee on Consumer Products, made public their opinion about interactions between nanostructures and the skin. Their statements were made based on the sizes involved [ 2 ] and showed that only for particles smaller than 10 nm there is evidence of penetration as far as the dermis. For particles of 20 nm or larger there is no evidence of penetration into viable (undisrupted) skin layers. The conclusion summarizes experiments done on both human and porcine skin. The same document states that the situation is different for hair follicles which allow deep penetration of particles 20 nm or larger and can function as reservoirs for nanoparticles. Mechanical effects on the skin (e.g. wrinkles, fl exing) affect (modulate) penetration as well.Not all reports agree that particles larger than 20 nm do not penetrate into viable skin layers. Baroli et al. describe experimental proof of these particles' access into the epidermis [ 3 ] whereas Prow et al., while agreeing that nanoparticles get into the stratum corneum (SC), refute their penetration into the epidermis [ 4 ]. The two studies used different nanospecies and methodologies which may provide valid reasons for the disagreement.Another study [ 5 ] mentions slightly different size limits in connection with penetration into the skin. Nanoparticles smaller than 13 nm can easily penetrate deeply while the 25 nm ones can only reach into 3-5 layers of the SC. Penetrating beyond the SC barrier is the highest hurdle for skin medications and for skin care cosmetics. In a recent study [ 6 ] Chen et al. defi ne the molecular weight limit above which particles do not penetrate intact epidermis as 500 Da. Yet another study [ 7 ] sets the limit at 600 Da for a species to "signifi cantly permeate the skin" but does not exclude the capability of heavier species to enter SC and, by interfering with its assembly, enable other nanospecies to penetrate it.For any valid conclusions to be drawn and further scenarios to be written, it is necessary to make comparisons between materials within the same category (size,

show abstract

Docetaxel-Loaded Solid Lipid Nanoparticles: Preparation, Characterization, In Vitro, and In Vivo Evaluations

Cited by 92 publications

References 25 publications

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

p-Hydroxy benzoic acid-conjugated dendrimer nanotherapeutics as potential carriers for targeted drug delivery to brain: an in vitro and in vivo evaluation

Nanoparticles, Nanomaterials and Nanocarriers

Contact Info

Product

Resources

About