Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer

Zhu, Dunwan; Tao, Wei; Zhang, Hongling; Liu, Gan; Wang, Teng; Zhang, Linhua; Zeng, Xiaowei; Mei, Lin

doi:10.1016/j.actbio.2015.11.031

Cited by 238 publications

(125 citation statements)

References 54 publications

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“…31 Targeted drug delivery, which can carry drugs to specific organs or tissues, is another highly desirable treatment technique in cancer nanotechnology. [32][33][34] The cell-penetrating peptide (CPP) trans-activating transcriptional activator (TAT) is commonly used in payload delivery into cells both in the natural L-configuration and as a D-amino acid peptide. 35 The improved activity and penetration of drugs delivered with TAT can be made use of to improve the efficacy of the standard drug dose, attenuate side effect, and overcome drug resistance.…”

mentioning

confidence: 99%

Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer

Liu¹,

Liang²,

Liu³

et al. 2017

IJN

103

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Background Cervical cancer is a major world health problem for women. Currently, cancer research focuses on improving therapy for cervical cancer using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers. Purpose The aim of this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) for co-delivery of paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order to achieve synergistic antitumor activity against cervical cancer. Methods Lipid prodrug of CDDP (TOS-CDDP) and TAT-containing polyethylene glycol-distearoyl-phosphatidylethanolamine (TAT-PEG-DSPE) were synthesized. TAT PTX/TOS-CDDP SLNs were prepared by emulsification and solvent evaporation method. Physicochemical characteristics of SLNs such as size, morphology, and release profiles were explored. In vitro and in vivo studies were carried out to assess the efficacy of their antitumor activity in target cells. Results TAT PTX/TOS-CDDP SLNs could be successfully internalized by HeLa cells and showed a synergistic effect in the suppression of cervical tumor cell growth. They exhibited high tumor tissue accumulation, superior antitumor efficiency, and much lower toxicity in vivo. Conclusion The present study indicates that the co-delivery system provides a promising platform as a combination therapy for the treatment of cervical cancer, and possibly other types of cancer as well.

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mentioning

confidence: 99%

Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer

Liu¹,

Liang²,

Liu³

et al. 2017

IJN

103

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“…35,36 The immune response might be influenced by particle size, surface charge, and drug release, which may be attributed to the interaction between the cell and particle during cellular uptake. 37,38 Table 3 and Figure 4 show that the PHYP nanospheres had a spherical shape with smooth surface and narrow size distribution.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of optimum conditions for pachyman encapsulated in poly(D,L-lactic acid) nanospheres by response surface methodology and results of a related in vitro study

Zheng

Luo

et al. 2016

IJN

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This study aimed to optimize the preparation conditions of pachyman (PHY)-loaded poly( d,l -lactic acid) (PLA) (PHYP) nanospheres by response surface methodology, explore their characteristics, and assess their effects on splenic lymphocytes. Double emulsion solvent evaporation was used to synthesize PHYP nanospheres, and the optimal preparation conditions were identified as a concentration of poloxamer 188 (F68) (w/v) of 0.33%, a concentration of PLA of 30 mg/mL, and a ratio of PLA to drug (w/w) of 10.25:1 required to reach the highest encapsulation efficiency, which was calculated to be 59.10%. PHYP had a spherical shape with a smooth surface and uniform size and an evident effect of sustained release and relative stability. Splenic lymphocytes are crucial and multifunctional cells in the immune system, and their immunological properties could be enhanced significantly by PHYP treatment. This study confirmed that PHY encapsulated in PLA nanospheres had comparatively steady properties and exerted obvious immune enhancement.

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“…The in vivo biodistribution experiments show that the Gal-pD-TPGS-PLA/NPs were specifically targeted to the tumor. Furthermore, the in vivo anti-tumor effects study showed that injecting DTX-loaded Gal-pD-TPGS-PLA/NPs reduced the tumor size most significantly on hepatoma-bearing nude mice [18]. Yeo et al functionalized poly(lactic-co-glycolic acid) (PLGA) NPs with folate, Arg-Gly-Asp, and poly(carboxybetaine methacrylate) as surface modifiers, which showed no cytotoxicity [19].…”

Section: Pda Capsules and Nps As Carriers For Drug Deliverymentioning

confidence: 99%

Polydopamine-based Materials as Carriers for Drug Delivery

Cui¹,

Wang²,

Yin³

et al. 2016

Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

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Abstract. Polydopamine (PDA)-based material with tailored structures and properties are of particular interests due to their multifunctions and potential applications as new colloidal structures in diverse field. The past several years has witnessed a rapid increase of research concerning the new fabrication strategies, functionalization and applications of PDA-based materials in drug delivery. In this review, the very recent progress of PDA-based materials as carriers for drug delivery are summarized.

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Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer

Cited by 238 publications

References 54 publications

Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer

Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer

Evaluation of optimum conditions for pachyman encapsulated in poly(D,L-lactic acid) nanospheres by response surface methodology and results of a related in vitro study

Polydopamine-based Materials as Carriers for Drug Delivery

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