Do Vitamins or Minerals (Apart From Lithium) Have Mood-Stabilizing Effects?

Micronutrients Versus Standard Medication Management in Autism: A Naturalistic Case–Control Study

“…The results reported in this case-control study are consistent with the mood-stabilizing effects documented for this same formula in a variety of other diagnoses: BPD, anxiety, OCD, and so on (Kaplan et al 2001;Popper 2001;Kaplan et al 2002;Simmons 2002;Kaplan et al 2004;Frazier et al 2009;Gately and Kaplan, 2009;Rucklidge 2009). This similarity raises the question of cooccurring mood disorders in the sample in the current study.…”

“…An older version of the 36-ingredient supplement used in the current study has been the topic of other investigations. Four were open-label investigations in adults, adolescents, and children with bipolar disorder (BPD) (Kaplan et al 2001;Popper 2001;Simmons 2002;Kaplan et al 2004). In addition, 2 children with developmental disabilities (one on the autism spectrum) were studied in within-subject cross-over designs: On-off control of their tantrums and rages was demonstrated with these micronutrients .…”

Nutritional and Safety Outcomes from an Open-Label Micronutrient Intervention for Pediatric Bipolar Spectrum Disorders

“…In 2008 alone, >2000 children were administered this supplement for mood concerns (Truehope, personal communication, May 7, 2008), but randomized controlled trials (RCTs) have not been conducted in children with mood disorders. Results from an animal study (Halliwell and Kolb 2003), case studies, and open-label trials in both youth and adults support benefit for mood symptoms (Kaplan et al 2001;Popper 2001;Kaplan et al 2002;Simmons 2003;Kaplan et al, 2004;Frazier et al 2009;Rucklidge 2009;Mehl-Madrona et al 2010;Rucklidge and Harrison 2010;, self-injurious behavior (Mehl-Madrona et al 2010), hyperactivity/impulsivity (Mehl-Madrona et al 2010;Rucklidge & Harrison 2010;, inattention , and anxiety (Kaplan et al 2002;Frazier et al 2009;Rucklidge 2009;Rucklidge and Harrison 2010;. These results call for additional scientific investigation.…”

Database Analysis of Adults with Bipolar Disorder Consuming a Micronutrient Formula

“…7 Since about 2000, there has been increasing evidence that multi-ingredient formulas of micronutrients (primarily vitamins and minerals, but also including fatty acids, amino acids, and botanicals) may be signifi cantly more benefi cial than single-ingredient nutritional interventions. [8][9][10][11][12][13][14][15][16][17] In each of these case studies, case series and clinical trials, the intervention has consisted of 20 or more micronutrients, and large effect sizes have been reported. In two case studies, on-off control of mood and temper problems were demonstrated using ABAB reversal designs, with benefi ts sustained for 4 years.…”