Do Triclosan Sutures Modify the Microbial Diversity of Surgical Site Infections? A Systematic Review and Meta-Analysis

Daoud, F.; Coppry, Maïder; Moore, Nicholas; Rogues, Anne-Marie

doi:10.3390/microorganisms10050927

Cited by 5 publications

(2 citation statements)

References 60 publications

(69 reference statements)

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“…[ 14 , 15 ]. Moreover, TCS-coated sutures have shown a significant reduction of the risk of surgical site infections (SSIs) during surgical interventions [ 16 ], even though this finding is almost controversial [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.

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Section: Introductionmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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“…23 Although there are several in vitro and in vivo studies that demonstrated the antimicrobial effect of triclosan-coated surgical sutures against SSIs related bacteria, Daoud et al indicated presence of insufficient evidence to declare the efficiency of the triclosan against SSIs. 27 Chlorhexidine is another substance that has been used as a biguanide antiseptic for years and has antimicrobial activity against various bacteria that emerge SSIs. 26 Several performed studies have demonstrated the success of chlorhexidine-coated surgical sutures in vitro.…”

Section: Introductionmentioning

confidence: 99%

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

et al. 2022

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Surgical site infections are commonly encountered as a risk factor in clinics that increase the morbidity of a patient after a surgical operation. Surgical sutures are one of the leading factor for the formation of surgical site infections that induce bacterial colonization by their broad surface area. Current strategies to overcome with surgical site infections consist utilization of antibiotic agent coatings such as triclosan. However, the significant increase in antibiotic resistance majorly decreases their efficiency against recalcitrant pathogens such as; Pseudomonas aeruginosa and Staphylococcus aureus. Therefore, the development of a multi drug-resistant antimicrobial suture without any cytotoxic effect to combat surgical site infections is vital. Antimicrobial peptides are the first defense line which has a broad range of spectrum against Gram-positive, and Gram-negative bacteria and even viruses. In addition, antimicrobial peptides have a rapid killing mechanism which is enhanced by membrane disruption and inhibition of functional proteins in pathogens without the development of antimicrobial resistance. In the scope of the current study, the antimicrobial effect of antimicrobial peptide conjugated poly (glycolic acid-co-caprolactone) (PGCL) sutures were investigated against P. aeruginosa and methicillin-resistant S. aureus (MRSA) strains by using antimicrobial peptide sequences of KRFRIRVRV-NH2, RWRWRWRW-NH2 and their dual combination (1:1). In addition, in vitro wound scratch assays were performed to evaluate the effect of antimicrobial peptide conjugated sutures on keratinocyte cell lines. Our results indicated that antimicrobial peptide modified sutures could be a potential novel medical device to overcome surgical site infections by the superior acceleration of wound healing.

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Assessing silver nanoparticle and antimicrobial combinations for antibacterial activity and biofilm prevention on surgical sutures

Al-Sawarees,

Darwish,

Abu-Zurayk

et al. 2024

Journal of Applied Microbiology

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Aims To evaluate the effect of silver nanoparticles alone and in combination with Triclosan, and trans-cinnamaldehyde against S.aureus and E.coli biofilms on sutures to improve patients’ outcomes. Methods and results Silver nanoparticles were prepared by chemical method and characterized by UV–visible spectrophotometer and dynamic light scattering. The minimum inhibitory concentration was assessed by the Microdilution assay. The antibiofilm activity was determined using crystal violet assay. A checkerboard assay using the fractional inhibitory concentration index and time-kill curve was used to investigate the synergistic effect of silver nanoparticle combinations. The hemolytic activity was determined using Erythrocyte Hemolytic Assay. Our results revealed that silver nanoparticles, Triclosan, and trans-cinnamaldehyde inhibited S.aureus and E.coli biofilms. Silver nanoparticles with trans-cinnamaldehyde showed a synergistic effect (FICI values 0.35 and 0.45 against S.aureus and E.coli biofilms, respectively), and silver nanoparticles with Triclosan showed complete inhibition of S.aureus biofilm. The hemolytic activity was < 2.50% for the combinations. Conclusion and Impact of the study This study showed that combinations of trans-cinnamaldehyde and Triclosan with silver nanoparticles enhanced surgical suture performance and thus have a promising application in the prevention of surgical site infections.

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Do Triclosan Sutures Modify the Microbial Diversity of Surgical Site Infections? A Systematic Review and Meta-Analysis

Cited by 5 publications

References 60 publications

Triclosan: A Small Molecule with Controversial Roles

Triclosan: A Small Molecule with Controversial Roles

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

Assessing silver nanoparticle and antimicrobial combinations for antibacterial activity and biofilm prevention on surgical sutures

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