Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina?

Itakura, Haruka; Sobel, Burton E.; Boothroyd, Derek B.; Leung, Lawrence L.K.; Iribarren, Carlos; Go, Alan S.; Fortmann, Stephen P.; Quertermous, Thomas; Hlatky, Mark A.

doi:10.1016/j.ahj.2007.09.015

Cited by 24 publications

(26 citation statements)

References 15 publications

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“…Although some studies have found increased t-PA and PAI-1 levels to be associated with an increased risk of arterial disease, [27][28][29] several studies have found no association, 5,30,31 and in 2 studies even a trend toward a decreased risk was found in subjects with elevated PAI-1. 30,32 These inconsistent results have been ascribed to the adjustments made for confounders in the analyses because these vary across studies. 4,6 In the ECAT study, the prognostic value of t-PA and PAI-1 was studied after adjustment for clusters of confounding variables.…”

Section: Org Frommentioning

confidence: 99%

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men

Meltzer

Doggen

Groot

et al. 2010

Blood

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Hypofibrinolysis as measured with overall clot lysis assays is associated with risk of arterial thrombosis. Individual components of the fibrinolytic system, however, have not been studied extensively in relation to arterial disease, or results of studies were inconsistent. The relation between plasminogen and ␣2-antiplasmin levels and cardiovascular risk factors and the association between plasminogen, ␣2-antiplasmin, tissue-plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) and risk of myocardial infarction was investigated in the Study of Myocardial Infarctions Leiden (555 men with a first myocardial infarction and 635 controls). ␣2-antiplasmin was associated with age and lipid levels, whereas plasminogen correlated with lipids, C-reactive protein, and smoking. Increased levels of all fibrinolytic factors were associated with myocardial infarction. Age-adjusted odds ratios (ORs; 95% confidence interval) for quartile 4 compared with 1 were 1.7 (1.2-2.3) for plasminogen, 1.9 (1.3-2.6) for ␣2-antiplasmin, 1.2-2.3) for t-PA, and 1.7 (1.2-2.4) (

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Section: Org Frommentioning

confidence: 99%

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men

Meltzer

Doggen

Groot

et al. 2010

Blood

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“…Elevated D-dimer levels in apparently healthy males have been shown to predict the future occurrence of AMI, ACS and coronary heart disease (121,184,185). Further, patients in whom the first presentation of coronary heart disease is with AMI may have higher D-dimer levels than patients who first present with stable angina (186). A weak but statistically significant correlation has been demonstrated between plasma D-dimer levels and severity of coronary disease on angiography in patients with unstable angina (187,188).…”

Section: D-dimermentioning

confidence: 96%

Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective

Body¹,

Slevin²,

McDowell³

2012

Traditional and Novel Risk Factors in Atherothrombosis

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“…Another study by Itakura et al [19] showed that at a median of 15 weeks after presentation, plasma markers of coagulation and fibrinolysis (such as PAI-1) did not distinguish patients with acute MI from those with stable angina. This study may imply that our finding of a higher level of PAI-1 in STEMI is not a chronic elevation that predisposed these patient to STEMI as opposed to NSTEMI, but rather a short-term phenomenon that may be sufficient in the presence of a rupture plaque to favor STEMI.…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Plasminogen Activator Inhibitor-1 Levels to the ST Deviation Pattern of Acute Myocardial Infarction

Rott¹,

Leibowitz²,

Finci-Yeheskel³

et al. 2008

Cardiology

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Objectives: Myocardial infarction (MI) may be classified as ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI). Procoagulants such as plasminogen activator inhibitor-1 (PAI-1) as well as markers of inflammation such as C-reactive protein (CRP), serum amyloid A (SAA) and interleukin-6 (IL-6) are elevated in acute coronary syndromes. However, no study has examined whether levels of these markers differ in patients with STEMI as opposed to NSTEMI. We sought to determine whether there are differences in plasma levels of PAI-1, CRP, SAA or IL-6 in patients with STEMI compared to patients with NSTEMI. Methods: Seventy-six consecutive patients presenting with acute MI (37 with STEMI and 39 with NSTEMI) were prospectively enrolled. Blood samples were obtained from patients within 6 h from presentation and plasma PAI-1, CRP, IL-6 and SAA concentrations were measured. Results: Plasma levels of PAI-1 were significantly higher in patients with STEMI compared to NSTEMI: 85.7 ± 5 vs. 61.3 ± 5 ng/ml (p < 0.001), while CRP, SAA and IL-6 levels were not significantly different between STEMI and NSTEMI patients. Conclusions: Higher plasma PAI-1 levels in STEMI patients may contribute to the predilection of these patients to occlusive thrombi and STEMI.

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Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina?

Cited by 24 publications

References 15 publications

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men

Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective

The Relationship of Plasminogen Activator Inhibitor-1 Levels to the ST Deviation Pattern of Acute Myocardial Infarction

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