Do pathologists agree on how to diagnose takotsubo cardiomyopathy?

Angelini, Paolo

doi:10.1007/s12024-015-9739-8

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…The TTC spontaneously resolves within a few days in survivors of the acute event ( 43 ); gradually, increased spasticity related to CED gradually dissolves (unknown cause), and after approximately 1 week, TTC generally is no longer reproducible by ACh testing, and recurrent clinical TTC is extremely rare.…”

Section: The Heart In Covid-19mentioning

confidence: 99%

COVID-19 and the Heart: Could Transient Takotsubo Cardiomyopathy Be Related to the Pandemic by Incidence and Mechanisms?

Angelini

Postalian²,

Hernandez-Vila³

et al. 2022

Front. Cardiovasc. Med.

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Typical emergency hospital care during the COVID-19 pandemic has centered on pulmonary-focused services. Nonetheless, patients with COVID-19 frequently develop complications associated with the dysfunction of other organs, which may greatly affect prognosis. Preliminary evidence suggests that cardiovascular involvement is relatively frequent in COVID-19 and that it correlates with significant worsening of clinical status and mortality in infected patients. In this article, we summarize current knowledge on the cardiovascular effects of COVID-19. In particular, we focus on the association between COVID-19 and transient takotsubo cardiomyopathy (TTC)—two conditions that preliminarily seem epidemiologically associated—and we highlight cardiovascular changes that may help guide future investigations toward full discovery of this new, complex disease entity. We hypothesize that coronary endothelial dysfunction, along with septic state, inflammatory storm, hypercoagulability, endothelial necrosis, and small-vessel clotting, may represent a fundamental hidden link between COVID-19 and TTC. Furthermore, given the likelihood that new genetic mutations of coronaviruses or other organisms will cause similar pandemics and endemics in the future, we must be better prepared so that a substantial complication such as TTC can be more accurately recognized, its pathophysiology better understood, and its treatment made more justifiable, timely, and effective.

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Section: The Heart In Covid-19mentioning

confidence: 99%

COVID-19 and the Heart: Could Transient Takotsubo Cardiomyopathy Be Related to the Pandemic by Incidence and Mechanisms?

Angelini

Postalian²,

Hernandez-Vila³

et al. 2022

Front. Cardiovasc. Med.

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show abstract

“…Commonly, inconsistency is reported between the extent of the initial area of LV akinesia or dyskinesia (the apparent extent of the myocardial injury) and the peak elevation of serum cardiac enzyme levels, in comparison to an equivalent area of a typical acute myocardial infarction [10,11].…”

Section: What Is Transient Takotsubo Cardiomyopathy?mentioning

confidence: 99%

“…Hospital mortality is relatively low (about 2-5%); however, it is likely that mortality mainly occurs during the first hour(s) after the onset of symptoms, usually in an extra-hospital environment, and therefore is significantly underreported [11][12][13]. This notion is supported by the fact that autopsy studies commonly do not reveal myocardial histologic changes typical of myocardial infarction [11,12].…”

Section: What Is Transient Takotsubo Cardiomyopathy?mentioning

confidence: 99%

Opportunities and Limitations in the Study of Transient Takotsubo Syndrome in Animal Models

Angelini¹,

Gamero

2020

J Clin Med Res

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Coronary Sclerosis, Myocardial Infarction, Myocarditis, Cardiomyopathy, Coronary Anomalies, and the Cardiac Conduction System

Dettmeyer¹

2018

Forensic Histopathology

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Do pathologists agree on how to diagnose takotsubo cardiomyopathy?

Cited by 6 publications

References 2 publications

COVID-19 and the Heart: Could Transient Takotsubo Cardiomyopathy Be Related to the Pandemic by Incidence and Mechanisms?

COVID-19 and the Heart: Could Transient Takotsubo Cardiomyopathy Be Related to the Pandemic by Incidence and Mechanisms?

Opportunities and Limitations in the Study of Transient Takotsubo Syndrome in Animal Models

Coronary Sclerosis, Myocardial Infarction, Myocarditis, Cardiomyopathy, Coronary Anomalies, and the Cardiac Conduction System

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