Do overall treatment time, field size, and treatment energy influence local control of T1–T2 squamous cell carcinomas of the glottic larynx?

Primary Radiotherapy of Tl and T2 Glottic Carcinoma: Analysis of treatment results and prognostic factors in 223 patients

“…Radiotherapy of patients with TI glottic carcinoma has been reported to give a high cure rate with few late complications (2,3,7,(10)(11)(12)(15)(16)(17)(18). Several series with local control rates in excess of 90% have been reported (5,12,15,16,20,25,26).…”

“…In the univariate analysis a treatment interruption of 7 days or more showed a significant impact, but this was lost in the multivariate analysis. Several authors have shown total treatment time to predict treatment outcome and therefore treatment interruptions are not recommended (16,18,22,24,25,27).…”

“…Optimal treatment demands tumour control and preservation of laryngeal function. Radiotherapy offers the possibility of preservation of voice quality and local control rates between 80% to 95% and 65% to 85% for T1 and T2 tumours respectively (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Factors related to tumour (6, 7, 10, 1 I, 13, 15, 19-21, 23), patient (15,21,23) and treatment (12, 14, 16-18, 22, 24-27), explaining the heterogeneity in treatment outcome, have been searched for, especially among T2 tumours.…”

Results of Radiotherapy for T1 Carcinoma of the Glottis by Fractions of 2.3 Gy per Day

“…One of the most important factors affecting treatment outcome in head and neck carcinomas is the overall treatment time (5)(6)(7)(8). In order to reduce treatment duration, one must not only avoid treatment interruptions in therapy but also apply a short overall treatment time.…”

Hypofractionated accelerated radiotherapy in T1–3 N0 cancer of the larynx: A prospective cohort study with historical controls

“…[1][2][3][4] It has been estimated that longer RT duration reduces local control of the tumor by 3-25% (median 15%) after 1 week and 5-42% (median 26%) after 2 weeks prolongation. 5 If RT delivery is shortened by 1 week, outcome improves by up to 9%.…”