Results of Radiotherapy for T1 Carcinoma of the Glottis by Fractions of 2.3 Gy per Day

Plataniotis, George A.; Kouvaris, John; Hatzimichalis, Helias J.; Papavasiliou, C.; Vlachos, L.

doi:10.3109/02841869709001275

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“…In our University we have established the 2.3 Gy per fraction as a standard treatment from 1997 when we also initially reported on the efficacy of accelerated hypofractionated radiotherapy for glottic carcinoma 7. With this current study we are reporting our experience in terms of the treatment outcome (response and toxicity).…”

Section: Introductionmentioning

confidence: 94%

Evaluation of acute/late toxicity and local recurrence in Τ1-Τ2 glottic carcinoma treated with accelerated hypofractionated 3D-conformal external beam radiotherapy (3D-CRT)

Kouloulias

Zygogianni

Mosa³

et al. 2013

Radiology and Oncology

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BackgroundThe aim of the study was to evaluate the efficacy, as well as the acute and late toxicity of an accelerated hypofractionated 3DCRT schedule as radical treatment in patients with organ confined glottic cancer cT1-2N0.Patients and methods.Between June of 2004 and September 2010, 47 retrospectively selected patients (29 males, 18 females) diagnosed with organ confined T1 or T2 glottic cancer, were treated with external 3DCRT in an accelerated hypofractionation schedule. The median age was 70 years. A dose of 64.4 Gy in 28 daily fractions was prescribed. The primary study endpoints were to assess the acute and late effects of radiation toxicity, according to the EORTC/ RTOG scale, as well as the therapeutic impact of this schedule in terms of local recurrence.ResultsThe median follow up was 36 months. At the end of radiotherapy, grade I, II and III acute toxicity was observed in 34, 9 and4 patients, respectively. Late grade I and II toxicity was observed in 25 and in 8 patients respectively. Only two local recurrences were observed, 15 and 24 months post 3DCRT respectively.ConclusionsOur radiotherapy schedule achieves a high locoregional control rate with the advantage of voice preservation. The proposed hypofractionated schedule can be recommended as a standard radiotherapy treatment, since these results are comparable with those of conventional fractionation schedules.

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Section: Introductionmentioning

confidence: 94%