2010
DOI: 10.1007/s10555-010-9234-3
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Do nutraceutics play a role in the prevention and treatment of colorectal cancer?

Abstract: Colorectal cancer is the third most common cancer worldwide with a 5-year survival of 50%. Current chemotherapeutic regimens used for advanced colorectal cancer provide an average survival of approximately 20 months. Non-toxic agents such as nutraceutics and supplements have been shown to aid in the prevention and adjuvant treatment of colorectal cancer. This article will discuss the epidemiology, progression, prevention, treatment, and recurrence of colorectal cancer and the role of nutraceutics and supplemen… Show more

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Cited by 24 publications
(22 citation statements)
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“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the remodeling of connective tissue [1]. One subgroup of MMPs called gelatinases (MMP-2 and MMP-9) has been particularly recognized as important mediators in inflammation [2] and oncologic processes such as tumorigenesis, cell adhesion and metastasis [3,4,5,6,7].…”
Section: Introductionmentioning
confidence: 99%
“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the remodeling of connective tissue [1]. One subgroup of MMPs called gelatinases (MMP-2 and MMP-9) has been particularly recognized as important mediators in inflammation [2] and oncologic processes such as tumorigenesis, cell adhesion and metastasis [3,4,5,6,7].…”
Section: Introductionmentioning
confidence: 99%
“…In the first model of CRC, the malignancy begins with somatic mutations in adenomatous polyposis coli (APC) gene, initiating transformation of the normal mucosa to adenoma (class I), which is shown to be associated with hyper-proliferation (35). The hyper-proliferation is brought about by the activation of Wnt/β-catenin signal transduction pathways (46), followed by the activation of the proto-oncogene K-ras, a process that typically induces the transformation of an early adenoma to a class II type intermediate adenoma (57). These processes are then followed by the loss of function of the gene DCC (deleted in colorectal cancer DCC) resulting in the formation of class III adenoma (4).…”
mentioning
confidence: 99%
“…The hyper-proliferation is brought about by the activation of Wnt/β-catenin signal transduction pathways (46), followed by the activation of the proto-oncogene K-ras, a process that typically induces the transformation of an early adenoma to a class II type intermediate adenoma (57). These processes are then followed by the loss of function of the gene DCC (deleted in colorectal cancer DCC) resulting in the formation of class III adenoma (4). The last step involves p53 gene mutation, which is thought to transform an adenoma into an invasive or early cancer (57).…”
mentioning
confidence: 99%
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