Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?

Pamer, Eric G.; Bevan, Michael J.; Lindahl, Kirsten Fischer

doi:10.1016/0966-842x(93)90023-k

Cited by 29 publications

(13 citation statements)

References 30 publications

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“…Some Ib molecules, however, have been shown to present bacterial antigens [43]. Ia loci are, by definition, highly polymorphic, but as data on population-based polymorphism of specific loci in these highly expanded genes is currently impossible to obtain for Atlantic cod, we have only used conserved anchoring sites in this study as an indication of Ia or Ib function.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

et al. 2013

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Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The discovery that Atlantic cod (Gadus morhua) has lost important components of the MHC II pathway, accompanied by an unusually high number of MHC I genes, shed new light on the evolution and plasticity of the immune system of teleosts as well as in higher vertebrates. The overall aim of this study was to further investigate the highly expanded repertoire of MHC I genes using a cDNA approach to obtain sequence information of both the binding domains and the sorting signaling potential in the cytoplasmic tail. Here we report a novel combination of two endosomal sorting motifs, one tyrosine-based associated with exogenous peptide presentation by cross-presenting MHCI molecules, and one dileucine-based associated with normal MHC II functionality. The two signal motifs were identified in the cytoplasmic tail in a subset of the genes. This indicates that these genes have evolved MHC II-like functionality, allowing a more versatile use of MHC I through cross-presentation. Such an alternative immune strategy may have arisen through adaptive radiation and acquisition of new gene function as a response to changes in the habitat of its ancestral lineage.

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Section: Discussionmentioning

confidence: 99%

Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

et al. 2013

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“…There is evidence that these self-reactive T cell sub sets may play a beneficial role in combatting the infection. Possible mechanisms include lymphokine-induced activa tion of antimicrobial mechanisms in infected phagocytes, lysis of cells infected with inconspicious parasites, and the opportunity that microbes which have been replicating intracellularly and now are disseminating after host cell lysis may be subject to extracellular eradication [15][16][17], Some of the pathogens which provoke the activation of self-reactive T cells are cytosolic parasites, and this loca tion easily explains the association of their antigens to MHC class I molecules. However, the remaining microbes are endosomal parasites or even extracellular microorga nisms, and the mechanism how their antigens may load MHC class I molecules is difficult to understand.…”

Section: Cross-connections Between the M H C Class I And Class Ii Patmentioning

confidence: 99%

Coiling Phagocytosis: A Way for MHC Class I Presentation of Bacterial Antigens?

Rittig

Häupl²,

Burmester³

1994

Int Arch Allergy Immunol

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“…Class Ib molecules may be a useful target for peptide vaccine design [31]. Whereas the class Ia molecules might have 50 or more allelic forms, each of which binds peptides with a different sequence motif, the class Ib molecules have only one or a few alleles, which may even share their binding groove.…”

Section: Vaccine Designmentioning

confidence: 99%

Presentation of N-formylated peptides by H2-M3

Lindahl

Dabhi

Hovik

et al. 1995

Biochemical Society Transactions

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The major histocompatibility complex (MHC) stretches over more than 4Mb of DNA and encodes over a hundred genes [l]. The classical part of the human and the mouse MHC contains the same genes in the same order with few exceptions. Two or three genes encode MHC class la molecules, which play the major role in presenting Abbreviations used: CTL. cytotoxic T lymphocyte; H, histocompatability; Mta. maternally transmitted antigen; ER, endoplasmic reticulum; B2m. Bz-microglobulin; MHC, major histocompatibility complex.

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Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?

Cited by 29 publications

References 30 publications

Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy

Coiling Phagocytosis: A Way for MHC Class I Presentation of Bacterial Antigens?

Presentation of N-formylated peptides by H2-M3

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