Presentation of N-formylated peptides by H2-M3

Abstract

The major histocompatibility complex (MHC) stretches over more than 4Mb of DNA and encodes over a hundred genes [l]. The classical part of the human and the mouse MHC contains the same genes in the same order with few exceptions. Two or three genes encode MHC class la molecules, which play the major role in presenting Abbreviations used: CTL. cytotoxic T lymphocyte; H, histocompatability; Mta. maternally transmitted antigen; ER, endoplasmic reticulum; B2m. Bz-microglobulin; MHC, major histocompatibility complex.

Identification of Formyl Peptides from Listeria monocytogenes and Staphylococcus aureus as Potent Chemoattractants for Mouse Neutrophils

“…Interestingly, one of the peptides tested in this study, fMIVIL, was originally identified as a L. monocytogenes peptide that is presented to CTLs by the H2-M3 MHC class Ib molecule in mice (49, 50). H2-M3 is structurally different from G protein-coupled chemoattractant receptors such as FPRs, but it recognizes N-formyl peptides (51, 52) and is known to play a nonredundant role in host defense against L. monocytogenes (53, 54). Our identification of fMIVIL as a potent agonist for mFPR1 raises the possibility that there may be cross-talk between H2-M3 and the G protein-coupled mFPR1.…”

Stimulation of Vγ9/Vδ2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate

“…A variety of molecular species characteristic of microbial pathogens such as lipopolysaccharide, N-formylated peptides and bacterial DNA have been shown to be recognized as ''pathogen-associated molecular patterns'' via invariant receptors on antigenpresenting cells or lymphocytes (for review see Lindahl et al, 1995;Akira et al, 2001).…”

Mucosal associated invariant T cells: Don't forget your vitamins

“…As such, a unique role in antigen presentation is usually expected from these "non-classical" MHC-like molecules. For example, H2-M3 molecules have the unique capacity to present bacteria-derived N-formylated peptides [1], while members of the CD1 family, which includes the well-studied CD1d molecule, present lipid antigens [2].…”