Do newborn infants have passive immunity to pertussis?

Bass, James W.; Zacher, Lisa L.

doi:10.1097/00006454-198906000-00004

Cited by 23 publications

(5 citation statements)

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“…In agreement with this, a study of nonvaccinated 10-year-old Swedish children showed a good correlation between pertussis toxin serum antibodies and history of clinical pertussis, while no such correlation was found between FHA antibodies and history of pertussis [24]. It is not known whether newborns are protected from pertussis by maternal antibodies [25]. However, if serum antibodies against pertussis toxin, FHA and/or pertactin are protective, the results of the present and a previous study [8] indicate that protection should be transferred from mothers with antibodies to these antigens.…”

Section: Discussionmentioning

confidence: 73%

Serumantikörper gegen die Komponenten der Diphtherie-Tetanus-Pertussis-Vakzine bei polnischen Kindern in Beziehung zum Impfstatus

Torbicka

Lagergård²,

Trollfors³

1995

Infection

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In Poland vaccination against diphtheria, tetanus and pertussis (DTP) is recommended from 2-3 months of age. Three doses at approximately 6-week intervals are given. A booster dose of DTP is given at 19-24 months and boosters of DT at 6 and 14 years. In this study serum samples were obtained from 166 Polish children aged 2 weeks to 14 years. Vaccination status was verified from the children's Health Books. Antibodies were determined against pertussis toxin, filamentous hemagglutinin (FHA), pertactin, tetanus toxoid and diphtheria toxin. Antibodies of maternal original against all five antigens were detected in almost all sera from infants not yet vaccinated. Antibody levels increased with the number of vaccinations given. Children who had recently received the fourth vaccination had the highest antibody levels. Antibody levels decreased with time after the fourth vaccination for all antibodies except FHA. It was concluded that the Polish whole cell pertussis vaccine stimulates antibodies against pertussis toxin, FHA and pertactin, but that antibodies against FHA probably also are stimulated by cross-reacting antigens. Diphtheria toxin and tetanus toxoid antibodies were above protective levels in all vaccinated children, but the long-term decreases justify the booster dose at 14 years. Twenty-five of 166 children (15%) had a vaccination status which deviated from recommendations demonstrating a need to increase the vaccination rate.

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Section: Discussionmentioning

confidence: 73%

Serumantikörper gegen die Komponenten der Diphtherie-Tetanus-Pertussis-Vakzine bei polnischen Kindern in Beziehung zum Impfstatus

Torbicka

Lagergård²,

Trollfors³

1995

Infection

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“…There is still significant morbidity and mortality in the younger age group 26 There is little placentally transferred passive immunity to pertussis, and as accelerated primary vaccination is not complete until 4 months of age, young infants are highly susceptible to pertussis if exposed 7. In addition these children are much more likely to require hospitalisation (82%) and intensive care 6.…”

Section: Discussionmentioning

confidence: 99%

Pertussis is increasing in unimmunised infants: is a change in policy needed?

Ranganathan

Tasker

Booy

et al. 1999

Archives of Disease in Childhood

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The proportion and trend in absolute number of pertussis notifications in young infants has increased each year in England and Wales since the accelerated immunisation schedule was introduced. We report five infants all less than 3 months of age admitted with life threatening pertussis infection to two paediatric intensive care units. Despite aggressive cardiorespiratory support measures, three of the infants died. Pertussis remains a significant cause of morbidity and mortality in unimmunised infants. In this age group presentation is likely to be atypical and infection more severe. Public health measures to prevent the disease could be strengthened. Chemoprophylaxis should be oVered to susceptible contacts and booster vaccinations against pertussis considered. 1999;80:297-299) (Arch Dis Child

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“…Data are limited on hypotheses for the potential of decreased immunity among infants. 32 Increased exposure of young infants to B pertussis may have resulted from increased B pertussis circulation among individuals likely to transmit to infants. The most frequent sources for transmission of pertussis to infants appear to vary depending on the level of effective immunization coverage 33 and possibly other epidemiological factors such as family structure.…”

Section: Commentmentioning

confidence: 99%