Do modic changes, disc degeneration, translation and angular motion affect facet osteoarthritis of the lumbar spine

Paholpak, Permsak; Dedeogullari, Emin; Lee, Christopher; Tamai, Katsuto; Barkoh, Kaku; Sessumpun, Kittipong; Wang, Jeffrey C.; Buser, Zorica

doi:10.1016/j.ejrad.2017.11.023

Cited by 16 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given the nature of disc degeneration and its cascading effect on adjacent tissues and overall spine mechanical properties, it is often difficult to specify the fundamental treatment target. Disruption of normal disc biomechanical properties is associated with accelerated degeneration of other structures such as facet joints, and osteophyte formation due to adaptive bony changes or calcification of ligaments . Back pain patients commonly have associated leg pain and symptoms which are frequently secondary to nerve compression, due to stenosis caused by loss of disc height and/or bulging or herniation.…”

Section: Selecting Physiologically and Clinically Relevant Efficacy Mmentioning

confidence: 99%

“…Disruption of normal disc biomechanical properties is associated with accelerated degeneration of other structures such as facet joints, and osteophyte formation due to adaptive bony changes or calcification of ligaments. 102,103 Back pain patients commonly have associated leg pain and symptoms which are frequently secondary to nerve compression, due to stenosis caused by loss of disc height and/or bulging or herniation. Consequently, stabilization (if not restoration) of disc structure is a key goal.…”

Section: Minimizing Potential Risks To Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

et al. 2018

View full text Add to dashboard Cite

Intervertebral disc degeneration is strongly associated with chronic low back pain, a leading cause of disability worldwide. Current back pain treatment approaches (both surgical and conservative) are limited to addressing symptoms, not necessarily the root cause. Not surprisingly therefore, long‐term efficacy of most approaches is poor. Cell‐based disc regeneration strategies have shown promise in preclinical studies, and represent a relatively low‐risk, low‐cost, and durable therapeutic approach suitable for a potentially large patient population, thus making them attractive from both clinical and commercial standpoints. Despite such promise, no such therapies have been broadly adopted clinically. In this perspective we highlight primary obstacles and provide recommendations to help accelerate successful clinical translation of cell‐based disc regeneration therapies. The key areas addressed include: (a) Optimizing cell sources and delivery techniques; (b) Minimizing potential risks to patients; (c) Selecting physiologically and clinically relevant efficacy metrics; (d) Maximizing commercial potential; and (e) Recognizing the importance of multidisciplinary collaborations and engaging with clinicians from inception through to clinical trials.

show abstract

Section: Selecting Physiologically and Clinically Relevant Efficacy Mmentioning

confidence: 99%

Section: Minimizing Potential Risks To Patientsmentioning

confidence: 99%

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Through the 2D or 3D processing of medical images, doctors are able to observe the digital images in multiple directions; by locating and segmenting the region of interest of the images, the qualitative and quantitative analysis of the lesion regions could be achieved, which could improve the accuracy of clinical diagnosis and reduce the workload of doctors at the same time. In addition, doctors could analyze the dynamic parameters of lumbar motions by counting the results of continuous image sequence processing and understand the features of lumbar motions, which has important reference value for the diagnosis and treatment of lumbar intervertebral disc diseases [12]. In this study, the related algorithms of key feature extraction in Gabor wavelet transformation were discussed, and the localizing effects of feature extraction on intervertebral disc in lumbar diseases were analyzed.…”

Section: Introductionmentioning

confidence: 99%

The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes

Yang

Liang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

ObjectiveBased on the theoretical basis of Gabor wavelet transformation, the application effects of feature extraction algorithm in Magnetic Resonance Imaging (MRI) and the role of feature extraction algorithm in the diagnosis of lumbar vertebra degenerative diseases were explored. Q, et al. (2020) The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes. PLoS ONE 15(2): e0227894. https://doi.org/10. ConclusionThe feature extraction algorithm based on Gabor wavelet transformation could easily and quickly realize the localization of the lumbar intervertebral disc, and the accuracy of the results was ensured. In addition, from the aspect of vertebral body tracking, the tracking effects based on the KLT algorithm were better and faster than those based on the maximum mutual information method.

show abstract

“…Lumbar Modic changes detected by MRI have been linked to disc degeneration and low back pain. In a recent study with subjects reporting low back pain, the presence of Modic type 1e3 changes was correlated with the presence and severity of disc degeneration in particular at segments L4-L5 and L5-S1, and also with the presence of facet OA, but not with the severity of facet OA 39 . Furthermore, the findings showed significant correlation of facet OA with disc degeneration and increased translation motion.…”

Section: Prediction Prognostic and Progression Studiesmentioning

confidence: 89%

Osteoarthritis year in review 2018: imaging

Nieminen

Casula

Nevalainen

et al. 2019

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Purpose: To provide a narrative review of the most relevant original research published in 2017/2018 on osteoarthritis imaging. Methods: The PubMed database was used to recover all relevant articles pertaining to osteoarthritis and medical imaging published between 1 April 2017 and 31 March 2018. Review articles, case studies and in vitro or animal studies were excluded. The original publications were subjectively sorted based on relevance, novelty and impact. Results and conclusions: The publication search yielded 1,155 references. In the assessed publications, the most common imaging modalities were radiography (N ¼ 708) and magnetic resonance imaging (MRI) (355), followed by computed tomography (CT) (220), ultrasound (85) and nuclear medicine (17). An overview of the most important publications to the osteoarthritis (OA) research community is presented in this narrative review. Imaging studies play an increasingly important role in OA research, and have helped us to understand better the pathophysiology of OA. Radiography and MRI continue to be the most applied imaging modalities, while quantitative MRI methods and texture analysis are becoming more popular. The value of ultrasound in OA research has been demonstrated. Several multi-modality predictive models have been developed. Deep learning has potential for more automatic and standardized analyses in future OA imaging research.

show abstract

Do modic changes, disc degeneration, translation and angular motion affect facet osteoarthritis of the lumbar spine

Cited by 16 publications

References 33 publications

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section

The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes

Osteoarthritis year in review 2018: imaging

Contact Info

Product

Resources

About