“…Examinations targeting a broader range of neurobiological systems implicated in behavioral and drug addictions, such as glutamatergic, serotonergic, noradrenergic, GABAergic, and stress hormonal systems (65), should be conducted in IGD. Intermediate phenotypes, including impulsivity, compulsivity, positive and negative valence systems measures, social cooperation, stress responsiveness, emotional processing, and others, warrant further investigation regarding their relevance to IGD (66–69), especially as some of these features have been linked to mental health in IGD (70). Other features like escapism and gaming-specific aspects (e.g., use of avatars, discrepancies between ideal/virtual and actual self) also warrant consideration (71–73).…”