Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma?

Mirghani, Haïtham; Amen, Furrat; Moreau, F.; Guily, Jean Lacau St

doi:10.1016/j.oraloncology.2014.11.011

Cited by 78 publications

(64 citation statements)

References 79 publications

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“…surmised that the increase in oropharyngeal cancer incidence in developed countries was due to factors other than smoking, notably HPV infection. HPV16 was shown to account for the vast majority (~95%) of HPV-positive oropharyngeal squamous cell carcinomas [33]. …”

Section: Discussionmentioning

confidence: 99%

The burden of HPV associated cancers in two regions in Nigeria 2012–2014

Jedy‐Agba

Dareng

Adebamowo

et al. 2016

Cancer Epidemiology

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Introduction HPV attributable cancers are the second most common infection-related cancers worldwide, with much higher burden in less developed regions. There are currently no country-specific estimates of the burden of these cancers in Nigeria just like many other low and middle income countries. Methods In this study, we quantified the proportion of the cancer burden in Nigeria that is attributable to HPV infection from 2012 to 2014 using HPV prevalence estimated from previous studies and data from two population based cancer registries (PBCR) in Nigeria. We considered cancer sites for which there is strong evidence of an association with HPV infection based on the International Agency for Research on Cancer (IARC) classification. We obtained age and sex-specific estimates of incident cancers and using the World Standard Population, we derived age standardized incidence (ASR) rates for each cancer type by categories of sex, and estimated the population attributable fractions (PAF). Results The two PBCR reported 4336 new cancer cases from 2012 to 2014. Of these, 1627 (37.5%) were in males and 2709 (62.5%) in females. Some 11% (488/4336) of these cancers were HPV associated; 2% (38/1627) in men and 17% (450/2709) in women. Of the HPV associated cancers, 7.8% occurred in men and 92.2% in women. The ASRs for HPV associated cancers was 33.5 per 100,000; 2.3 and 31.2 per 100,000 in men and women respectively. The proportion of all cancers attributable to HPV infection ranged from 10.2 to 10.4% (442–453 of 4336) while the proportion of HPV associated cancers attributable to HPV infection ranged from 90.6% to 92.8% (442–453 of the 488 cases). In men, 55.3% to 68.4% of HPV associated cancers were attributable to HPV infection compared to 93.6% to 94.8% in women. The combined ASR for HPV attributable cancers ranged from 31.0 to 31.7 per 100,000. This was 1.4 to 1.7 per 100,000 in men and 29.6 to 30.0 per 100,000 in women. In women, cervical cancer (n = 392, ASR 28.3 per 100,000) was the commonest HPV attributable cancer, while anal cancer (n = 21, ASR 1.2 per 100,000) was the commonest in men. Conclusions HPV attributable cancers constitute a substantial cancer burden in Nigerian women, much less so in men. A significant proportion of cancers in Nigerian women would be prevented if strategies such as HPV DNA based screening and HPV vaccination are implemented.

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Section: Discussionmentioning

confidence: 99%

The burden of HPV associated cancers in two regions in Nigeria 2012–2014

Jedy‐Agba

Dareng

Adebamowo

et al. 2016

Cancer Epidemiology

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“…It has a distinct role in cell cycle regulation [22], acting as a tumour suppressor protein. It is well known that detection of HPV infection with p16 INK4a staining often does not give accurate results [23, 24]. Another pitfall making survival comparisons even more difficult is the comparison of non-homogeneous groups.…”

Section: Introductionmentioning

confidence: 99%

Impact of HPV infection on oral squamous cell carcinoma

et al. 2016

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BackgroundHead and neck squamous cell carcinomas (HNSCC) are often divided by their aetiology. Noxae associated collectives are compared with the human papilloma virus (HPV)-associated group, whereas different localisations of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas are mostly discussed as one single group. Our aim was to show that classification by aetiology is not appropriate for OSCC.ResultsHPV DNA was detected by PCR in 7 (3.47%) patients, and we identified 12 (5.94%) positive (+) cases by p16INK4a immunostaining. Only 4 (1.98%) of the p16INK4a+ cases were + for HPV using PCR. Our homogenous collective of OSCC allowed us to compare HPV+ and HPV negative (−) patients without creating bias for tumour localisation, age, gender or tumour stage.Materials and methodsAfter testing OSCC samples for HPV positivity, we compared the results of two commonly used HPV detection methods, p16INK4a immunostaining and HPV DNA-related PCR, on 202 OSCC patients. HPV subtypes were determined with an HPV LCD Array Kit. Clinicopathological features of the patients were analysed, and the disease specific survival rates (DSS) for HPV+ and HPV− patients were obtained.Conclusionsp16INK4a immunostaining is a not a reliable HPV detection method for OSCC. Positive p16INK4a immunostaining did not agree with + results from PCR of HPV DNA. Furthermore, the influence of HPV-related oncogenic transformation in OSCC is overestimated. The significance of HPV infection remains clinically unclear, and its influence on survival rates is not relevant to OSCC cases.

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“…Recent studies have found that the frequency of HPV-16 infection in OSCC ranges from 10.6 to 81.3 % using PCR 3,[23][24][25][26][27][28] . In this study, HPV-16 positivity rates among all PT specimens were 39.2 % (51/130), which is within the range reported in the above-mentioned study.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Type 16 Infection and Local Lymph Node Metastasis in Patients with Squamous Cell Carcinoma

Kawai

Isomura

Sato

et al. 2016

J. Hard Tissue Biology.

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Human papillomavirus (HPV) infection is known to be an independent etiologic factor for oral squamous cell carcinoma (OSCC). Especially, HPV-16 is associated with a significant risk of developing OSCC. The most important prognostic factor in OSCC is local lymph node metastasis (LNM); therefore, knowledge of LNM status is crucial for selecting proper treatment plans. However, it is not clarify relationship between HPV-16 infection and LNM in OSCC. The purpose of this study was to determine the role of HPV-16 infection in LNM in OSCC. We analyzed 130 cases of OSCC (100 cases of OSCC without LNM; 30 cases of OSCC with LNM). HPV-16 infection was detected by PCR, immunohistochemical examination and in situ hybridization. HPV-16 positivity rates among primary tumor (PT) specimens without LNM were 43.0 % (43/100), and HPV-16 positivity rates among PT specimens with LNM were 26.7 % (8/30). In addition, HPV-16 positivity rates in both PT and LNM specimens in 30 OSCC patients with LNM were 10 % (3/30). OSCC with HPV-16 DNA detected by PCR showed positive staining on immunohistochemical examination and in situ hybridization. The HPV-16 infection rate in OSCC with LNM was significantly lower than that for OSCC without LNM. In the case of OSCC with LNM, HPV-16 infection rates for both in PT and LNM were low. This suggests that HPV-16 positive cases had a significantly lower risk of LNM when compared with patients having HPV-16 negative OSCC. The results of the present study suggest that HPV status in OSCC is able to act as a marker for risk of LNM.

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Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma?

Cited by 78 publications

References 79 publications

The burden of HPV associated cancers in two regions in Nigeria 2012–2014

The burden of HPV associated cancers in two regions in Nigeria 2012–2014

Impact of HPV infection on oral squamous cell carcinoma

Human Papillomavirus Type 16 Infection and Local Lymph Node Metastasis in Patients with Squamous Cell Carcinoma

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