Impact of HPV infection on oral squamous cell carcinoma

Götz, Carolin; Drecoll, Enken; Straub, Melanie; Bissinger, Oliver; Wolff, Klaus‐Dietrich; Kolk, Andreas

doi:10.18632/oncotarget.12501

Cited by 38 publications

(32 citation statements)

References 47 publications

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“…Kauppila et al suggested that high TLR 5 expression is associated with high rate of mortality and recurrences in oral mobile tongue SCC [17], and Ni et al suggested that high expression of TLR 7 could improve survival in oral SCC [21]. Although they did not study the HPV status in their series, HPV negativity in oral SCC is highly probable [37]. Therefore, our result showing that TLR 5 and 7 expression patterns are not associated with survival in HPV-negative OPSCC is in contrast with these findings.…”

Section: Discussionmentioning

confidence: 99%

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Jouhi

Mohamed

Mäkitie

et al. 2017

Cancer Immunol Immunother

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A large subset of oropharyngeal squamous cell carcinomas (OPSCCs) is associated with HPV infection and has better outcome than non-viral-related tumors. Various malignancies also carry a role for TLRs, key activators of inflammation and innate immunity. We examined the expression of TLRs in OPSCC, and their association with HPV status and treatment outcome. TLR 5, 7, 9, and p16 were studied by immunohistochemistry and HPV status was detected with in situ hybridization in 202 tumors of consecutively treated OPSCC patients using tissue microarray method. The relations between TLR expression and HPV status, p16 expression, clinicopathological factors, and survival were analyzed. TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative tumors, and they were statistically significantly associated with history of smoking, heavy drinking, tumor site, grade, size (T), metastasis (N), and stage. Moreover, in HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence. After adjustment, among HPV-positive OPSCC patients, high TLR 5 and low TLR 7 expression were associated with poor disease-specific survival. Our results indicate that TLR 5 and 7 may have a role in the prognostication of HPV-positive OPSCC, however, further studies are needed to clarify the comprehensive role of these TLRs in OPSCC.

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Section: Discussionmentioning

confidence: 99%

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Jouhi

Mohamed

Mäkitie

et al. 2017

Cancer Immunol Immunother

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“…As intraoperative controls, an intraoperative margin control and frozen sections were also obtained in each tumour operation. As previously described ( 30 ), adjuvant cisplatin-based chemoradiation was performed in cases of lymph node metastasis, extracapsular spread, tumour infiltration of the bone, tumours of extended size (T2-T4) and positive microscopic resection margins (R1) according to the S3 German guidelines for oral cancer. Patients were excluded from the study if no curative surgical treatment was performed and the primary treatment was radiochemotherapy.…”

Section: Methodsmentioning

confidence: 99%

“…The centre and invasive front of tumours of all study participants were included in the TMA ( 30 , 31 ). The tissues were formalin-fixed and paraffin-embedded in blocks ( 30 , 31 ). Two pathologists analysed the areas to be represented in the TMA.…”

Section: Methodsmentioning

confidence: 99%

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ALDH1 as a prognostic marker for lymph node metastasis in OSCC

et al. 2018

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Long-term survival in cases of head and neck squamous cell carcinoma, particularly oral squamous cell carcinoma (OSCC), remains a rare achievement in the field of clinical oncology. In recent years, the theory of cancer stem cells (CSCs) has emerged and been used to offer explanations for tumour recurrence and metastasis. The present aim was to investigate the role of aldehyde dehydrogenase 1 (ALDH1) as a CSC-marker for OSCC and to determine the role of p16ink4a, which is also a surrogate marker of human papilloma virus (HPV), in the expression of ALDH1. The study cohort comprised of 186 surgically-treated cases of OSCC. The primaries were located in the oral cavity. The expression of the CSC marker (CSCM) ALDH1 was evaluated via immunohistochemistry (IHC) of a tissue microarray. HPV detection was performed by polymerase chain reaction and an HPV Array kit. Furthermore, the IHC expression of p16ink4a was also analysed. Risk regression models as the Kruskal Wallis test was used to assess the association of CSCM and p16ink4a expression with tumour size and lymph node metastasis, and cox proportional hazards were analysed. Additionally, coexpression of the markers ALDH1 and p16ink4a was analysed with regard to associations with tumour classification. Overall, high expression of ALDH1 in lymph nodes was significantly associated with Union for International Cancer Control (UICC) stage IV (P=0.044) and T4 stage cancer (P=0.03). p16ink4a positivity, in cases of HPV negativity, was associated with worse survival rate compared with that of the total cohort (P=0.048). Collectively the data indicate that ALDH1 expression may be suitable for detection of unfavourable prognosis in OSCC patients, based in part on its apparent role as a marker of metastasis. HPV status was not statistically predictive of patient outcome or CSCM expression; however, p16ink4a remains a potential marker in HNSCC Further in vitro studies with ALDH1 and p16ink4a should be performed to evaluate the expression of ALDH1 and HPV in cell culture and to clarify the role of ALDH1 as a marker for increased invasiveness of OSCC cells.

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“…Unfavorably, the incidence is increasing with approximately 300,000 new reported cases annually, or 2.1% of the world total [1]. Risk factors include smoking, especially in combination with heavy alcohol consumption, nonvegetarian diet, poor oral hygiene, poor dentition [2], and in rare cases infections with human papilloma virus (HPV) [3].…”

Section: Introductionmentioning

confidence: 99%

Cervical Lymph Node Metastases in Oral Squamous Cell Carcinoma—How Much Imaging Do We Need?

et al. 2020

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Cervical lymph node metastases in oral squamous cell carcinoma (OSCC) are key predictors of disease specific survival. It was therefore the aim of this study to evaluate how much imaging is minimally needed for reliable and efficient identification of cervical lymph node metastases. In this retrospective cross-sectional study, results (metastasis yes/no) of ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) were compared to the final histopathological results of the corresponding neck dissection (ND) specimens (metastasis yes/no). A score was calculated to account for cervical lymph node size, shape, clustering, peripheral enhancement, hilus sign, architecture, blood flow, and central necrosis. Sensitivity and specificity were analyzed for each imaging technique separately. In 164 patients diagnosed with OSCC, 96 underwent uni- or bilateral ND (122 ND in total). One hundred percent sensitivity was achieved by CT+MRI, MRI+PET, US+CT+MRI, US+MRI+PET, CT+MRI+PET, and US+CT+MRI+PET. The highest specificity was realized by US with 79% (95% CI [0.698–0.890]). Specificity for CT+MRI and PET+MRI was 51% (95% CI [0.359–0.665]) and 70% (95% CI [0.416–0.984]), respectively. Regarding 100% sensitivity with acceptable specificity, the combination of CT+MRI or PET+MRI appeared to be suitable for staging cervical lymph nodes in primary OSCC.

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Impact of HPV infection on oral squamous cell carcinoma

Cited by 38 publications

References 47 publications

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

ALDH1 as a prognostic marker for lymph node metastasis in OSCC

Cervical Lymph Node Metastases in Oral Squamous Cell Carcinoma—How Much Imaging Do We Need?

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