Do GST polymorphisms influence in the pathogenesis of diabetic nephropathy?

Lima, Rayane Mendes de; Anjos, Laura Raniere Borges dos; Alves, Thales Biffe; Coelho, Alexandre Siqueira Guedes; Pedrino, Gustavo Rodrigues; Santos, Rodrigo da Silva; Cruz, Aldo Alfonso Alván De la; Reis, Ângela Adamski da Silva

doi:10.1016/j.mce.2018.07.001

Cited by 9 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 is excluded from the full text. As a result, 48 studies ( Fujita et al, 2000 ; Yang et al, 2004 ; Hayek et al, 2006 ; Wang et al, 2006 ; Hori et al, 2007 ; Yalin et al, 2007 ; Oniki et al, 2008 ; Nowier et al, 2009 ; Tiwari et al, 2009 ; Bid et al, 2010 ; Datta et al, 2010 ; Amer et al, 2011 ; Ramprasath et al, 2011 ; Tsai et al, 2011 ; Amer et al, 2012 ; Cilenšek et al, 2012 ; Gonul et al, 2012 ; Jana and Petrovic., 2012 ; Moasser et al, 2012 ; Dadbinpour et al, 2013 ; Grubisa et al, 2013 ; Mastana et al, 2013 ; Pinheiro et al, 2013 ; Vats et al, 2013 ; Abbasi et al, 2014 ; Al-Badran and Al-Mayah, 2014 ; Moasser et al, 2014 ; Purkait et al, 2014 ; Rao et al, 2014 ; Raza et al, 2014 ; Afrand et al, 2015 ; Rasheed et al, 2015 ; Stoian et al, 2015 ; Zaki et al, 2015 ; Etemad et al, 2016 ; Mergani et al, 2016 ; Mir et al, 2016 ; Rasheed et al, 2016 ; Ahmed and Al-Bachary, 2017 ; Azarova et al, 2018 ; de Lima et al, 2018 ; Abbas et al, 2019 ; Osman et al, 2019 ; Klusek et al, 2020 ; Pourkeramati et al, 2020 ; Gusti et al, 2021 ; Albeladi et al, 2022 ; Jamil et al, 2022 ) were included ( Figure 1 ). There were 28 articles (involving 4,878 cases and 4,621 controls, Table 1 ) on the GSTM1 present/null polymorphism, 28 articles (involving 4,710 cases and 4,471 controls, Table 2 ) on the GSTT1 present/null polymorphism, 24 studies on the GSTP1 IIe105Val polymorphism (including 4,297 cases and 4,244 controls, Table 3 ),17 studies inc...…”

Section: Resultsmentioning

confidence: 99%

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Backgrounds: Compared with previously published meta-analyses, this is the first study to investigate the combined effects of glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1 IIe105Val) and type 2 diabetes mellitus (T2DM) risk; moreover, the credibility of statistically significant associations was assessed; furthermore, many new original studies were published.Objectives: To determine the relationship between GSTM1, GSTT1, and GSTP1 polymorphisms with T2DM risk.Methods: PubMed, Embase, Wanfang, and China National Knowledge Infrastructure Databases were searched. We quantify the relationship using crude odds ratios and their 95% confidence intervals Moreover, the Venice criteria, false-positive report probability (FPRP), and Bayesian false discovery probability (BFDP) were used to validate the significance of the results.Results: Overall, significantly increased T2DM risk was found between individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on T2DM risk, but, combined effects of the GSTT1 and GSTP1 polymorphisms was not statistically significant. GSTT1 gene polymorphism significantly increases the risk of T2DM complications, while GSTM1 and GSTP1 polymorphisms had no statistical significance. The GSTM1 null genotype was linked to a particularly increased risk of T2DM in Caucasians; the GSTT1 null genotype was connected to a significantly higher risk of T2DM in Asians and Indians; and the GSTP1 IIe105Val polymorphism was related to a substantially increased T2DM risk in Indians. Moreover, the GSTM1 and GSTT1 double null genotype was associated with substantially increased T2DM risk in Caucasians and Indians; the combined effects of GSTM1 and GSTP1 polymorphisms was associated with higher T2DM risk in Caucasians. However, all significant results were false when the Venice criteria, FPRP, and BFDP test were used (any FPRP >0.2 and BFDP value >0.8).Conclusion: The current analysis strongly suggests that the individual and combined effects of GSTM1, GSTT1 and GSTP1 polymorphisms might not be connected with elevated T2DM risk.

show abstract

Section: Resultsmentioning

confidence: 99%

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Dadbinpour et al showed that the GSTT1 null genotype was not associated with the presence of DR in T2D patients (P = 0.187) but noticed an association between GSTM1 genotype and diabetic retinopathy (P = 0.04), in opposition with a Slovenian study which revealed that GSTM1 null genotype might have protective effects against diabetic retinopathy [40]. Moasser et al showed that lack of GSTM1 and the presence of GSTM1/GSTT1 null genotypes together were associated with the development T2D but there was no significant effect on the occurrence of DR [35]. A Slovakian study reported that GSTM1 and GSTT1 gene polymorphisms were associated with an increased risk of cardiovascular autonomic neuropathy in adolescents with T1D [45].…”

Section: Discussionmentioning

confidence: 86%

“…According to Sharma et al reduced GSH plasma levels were found to have significant association with increased risk of renal damage in T2D [34]. A study conducted within the Brazilian population on the relationship between the genetic polymorphism of GSTM1, GSTT1, and GSTP1 in the risk of developing DN did not find any statistically significant association between the GSTM1, GSTT1, and GSTP1 null genotypes and the development of DN [35]. In contrast, in an Iranian study, null GSTT1 and GSTM1 genotypes increased the risk for end-stage renal disease by 1.8 times (P < 0.001) [36].…”

Section: Discussionmentioning

confidence: 96%

Evaluation of glutathione S-transferase polymorphism in Iranian patients with type 2 diabetic microangiopathy

Hashemi‐Soteh

Amiri

Rezaee

et al. 2020

Egypt J Med Hum Genet

View full text Add to dashboard Cite

Background: Overproduction of reactive oxygen species as a result of hyperglycemia in diabetes mellitus leads to microvascular complications. Glutathione S-transferases play important detoxifying roles with antioxidant potentials. This study aimed to assess whether the glutathione S-transferase M1 and T1 genotypes were associated with type 2 diabetes mellitus microangiopathic complications in the Iranian population. Results: In this case-control study, the frequencies of null GSTM1 and GSTT1 genotypes were 4/72 (5.56%) and 12/ 72 (16.67%) respectively, in uncomplicated DM group. The frequencies of null GSTM1 and GSTT1 genotype in complicated DM group were 16/134 (11.94%) and 37/134 (27.61%), respectively. The proportion of GSTM1 null genotypes was higher in diabetic nephropathy compared to non-nephropathy (19.3% vs. 6.04 %, P = 0.006). At GSTT1 locus, patients with diabetic peripheral neuropathy had a higher frequency of deletion compared to those of without neuropathy (30.39% vs. 23.49%) (P = 0.02). Conclusion: Selective polymorphisms encoding GSTM1 and GSTT1genes may prove useful as genetic markers to recognize individuals with an increased trend in developing diabetic nephropathy and neuropathy, respectively. This will help better identify individuals at higher risk toward microvascular complications of type 2 diabetes due to genetic susceptibility.

show abstract

“… 37 Moreover, a study conducted in the Brazilian population did not detect any association between the null polymorphism of the GSTM1 and GSTT1 genes and DN development. 38 However, a study performed in an Iranian population showed that the GSTT1 and GSTM1 null genotypes increased the risk of late-stage renal diseases. 39 …”

Section: Discussionmentioning

confidence: 99%

Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus

Albeladi¹,

Mostafa²,

Zayed³

et al. 2022

IJGM

View full text Add to dashboard Cite

Introduction An imbalance between reactive oxygen species (ROS) generation and the defence mechanisms underlying the activity of antioxidant enzymes has been demonstrated as the leading pathology in diabetes mellitus (DM)-related microvascular complications. Purpose This study aims to evaluate the association between polymorphisms in antioxidant enzyme-encoding genes: catalase (CAT); manganese superoxide dismutase (Mn-SOD); glutathione S transferase M1 (GSTM1); and GSTT1 glutathione S transferase T1 (GSTT1), and the risk of type II diabetic nephropathy (DN) in the Saudi population. Patients and Methods The present study involved 64 type II DM patients with nephropathy and 64 type II diabetes patients without nephropathy from the King Abdulaziz University (KAU) Hospital. They underwent real-time PCR genotyping for the Mn-SOD and CAT genes. Multiplex PCR was used to detect GSTM1- and GSTT1-null polymorphisms. Results A statistically significant difference was observed between the case and control groups with regard to polymorphisms in the CAT gene (P = 0.037), but not for polymorphisms in the Mn-SOD (P = 0.64) gene. In addition, a statistically significant association was observed between null polymorphisms of the GSTT1 and GSTM1 genes and DN in the case and control groups (P = 0.046 and P = 0.035, respectively). Conclusion Our results showed that the genetic ability to combat oxidative stress may play a major role in DN pathogenesis in Saudi type II DM patients. These polymorphisms in antioxidant enzyme-encoding genes could be used as independent genetic markers for the construction of risk prediction models for kidney-related complications in type II DM patients.

show abstract

Do GST polymorphisms influence in the pathogenesis of diabetic nephropathy?

Cited by 9 publications

References 21 publications

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

Evaluation of glutathione S-transferase polymorphism in Iranian patients with type 2 diabetic microangiopathy

Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus

Contact Info

Product

Resources

About