Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus

Albeladi, Fatma; Mostafa, Mostafa M; Zayed, Mohamed A.; Atta, Hazem

doi:10.2147/ijgm.s367673

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…12 is excluded from the full text. As a result, 48 studies ( Fujita et al, 2000 ; Yang et al, 2004 ; Hayek et al, 2006 ; Wang et al, 2006 ; Hori et al, 2007 ; Yalin et al, 2007 ; Oniki et al, 2008 ; Nowier et al, 2009 ; Tiwari et al, 2009 ; Bid et al, 2010 ; Datta et al, 2010 ; Amer et al, 2011 ; Ramprasath et al, 2011 ; Tsai et al, 2011 ; Amer et al, 2012 ; Cilenšek et al, 2012 ; Gonul et al, 2012 ; Jana and Petrovic., 2012 ; Moasser et al, 2012 ; Dadbinpour et al, 2013 ; Grubisa et al, 2013 ; Mastana et al, 2013 ; Pinheiro et al, 2013 ; Vats et al, 2013 ; Abbasi et al, 2014 ; Al-Badran and Al-Mayah, 2014 ; Moasser et al, 2014 ; Purkait et al, 2014 ; Rao et al, 2014 ; Raza et al, 2014 ; Afrand et al, 2015 ; Rasheed et al, 2015 ; Stoian et al, 2015 ; Zaki et al, 2015 ; Etemad et al, 2016 ; Mergani et al, 2016 ; Mir et al, 2016 ; Rasheed et al, 2016 ; Ahmed and Al-Bachary, 2017 ; Azarova et al, 2018 ; de Lima et al, 2018 ; Abbas et al, 2019 ; Osman et al, 2019 ; Klusek et al, 2020 ; Pourkeramati et al, 2020 ; Gusti et al, 2021 ; Albeladi et al, 2022 ; Jamil et al, 2022 ) were included ( Figure 1 ). There were 28 articles (involving 4,878 cases and 4,621 controls, Table 1 ) on the GSTM1 present/null polymorphism, 28 articles (involving 4,710 cases and 4,471 controls, Table 2 ) on the GSTT1 present/null polymorphism, 24 studies on the GSTP1 IIe105Val polymorphism (including 4,297 cases and 4,244 controls, Table 3 ),17 studies inc...…”

Section: Resultsmentioning

confidence: 99%

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

et al. 2022

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Backgrounds: Compared with previously published meta-analyses, this is the first study to investigate the combined effects of glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1 IIe105Val) and type 2 diabetes mellitus (T2DM) risk; moreover, the credibility of statistically significant associations was assessed; furthermore, many new original studies were published.Objectives: To determine the relationship between GSTM1, GSTT1, and GSTP1 polymorphisms with T2DM risk.Methods: PubMed, Embase, Wanfang, and China National Knowledge Infrastructure Databases were searched. We quantify the relationship using crude odds ratios and their 95% confidence intervals Moreover, the Venice criteria, false-positive report probability (FPRP), and Bayesian false discovery probability (BFDP) were used to validate the significance of the results.Results: Overall, significantly increased T2DM risk was found between individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on T2DM risk, but, combined effects of the GSTT1 and GSTP1 polymorphisms was not statistically significant. GSTT1 gene polymorphism significantly increases the risk of T2DM complications, while GSTM1 and GSTP1 polymorphisms had no statistical significance. The GSTM1 null genotype was linked to a particularly increased risk of T2DM in Caucasians; the GSTT1 null genotype was connected to a significantly higher risk of T2DM in Asians and Indians; and the GSTP1 IIe105Val polymorphism was related to a substantially increased T2DM risk in Indians. Moreover, the GSTM1 and GSTT1 double null genotype was associated with substantially increased T2DM risk in Caucasians and Indians; the combined effects of GSTM1 and GSTP1 polymorphisms was associated with higher T2DM risk in Caucasians. However, all significant results were false when the Venice criteria, FPRP, and BFDP test were used (any FPRP >0.2 and BFDP value >0.8).Conclusion: The current analysis strongly suggests that the individual and combined effects of GSTM1, GSTT1 and GSTP1 polymorphisms might not be connected with elevated T2DM risk.

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Section: Resultsmentioning

confidence: 99%

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

et al. 2022

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“…T2DM patients who have the TT genotype in -262 C/T may have elevated risk of diabetes complications; these patients had the lowest mean CAT and HDL, as well as the highest glucose, HbA1 and TCH levels [ 57 ]. Additionally, there is evidence that CAT polymorphism is associated with diabetes complications, such as distal symmetric polyneuropathy, nephropathy, retinopathy and risk factors for its development [ 20 , 25 , 58 , 59 ]. In view of the significant relationship between T2DM and NAFLD [ 9 ], and the discussion related to the sequence of development of these pathologies as well as the etiopathogenetic factors involved in this process, it is worth considering the role of CAT, its genotypes and alleles in this process.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to genetic factors, the CAT level can be affected by age, seasonality, physical activity or the number of chemical compounds [ 18 , 19 ]. Alterations in the expression of the CAT gene and the CAT protein level have been reported in a wide variety of diseases, and polymorphisms in the CAT gene have been shown to be associated with various pathophysiological conditions, such as IR, T2DM, type 1 diabetes mellitus (T1DM), gestational diabetes, impaired glucose tolerance, HA, Alzheimer’s disease, breast cancer and therapy, asthma, osteonecrosis, elderly re-nutrition, and bone mineral density [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Some studies indicate a relationship between selected CAT polymorphisms and liver damage caused by chemical compounds [ 29 ], alcohol [ 30 ], medications such as valproic acid [ 31 ], hepatitis C and B viruses [ 32 , 33 ], as well as the presence of NASH [ 34 ] and HCC [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism

Kosmalski,

Szymczak-Pajor,

Drzewoski

et al. 2023

Cells

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Background: It is well known that oxidative stress plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). It has been suggested that an insufficient antioxidant defense system composed of antioxidant enzymes, including catalase (CAT) and nonenzymatic molecules, is a key factor triggering oxidative damage in the progression of liver disease. Therefore, the aim of our study was to assess whether the level of CAT and -262 C/T polymorphism in the promoter of CAT (rs1001179) are associated with NAFLD. Methods: In total, 281 adults (152/129 female/male, aged 65.61 ± 10.44 years) were included in the study. The patients were assigned to an NAFLD group (n = 139) or a group without NAFLD (n = 142) based on the results of an ultrasound, the Hepatic Steatosis Index, and the Fatty Liver Index (FLI). CAT levels were determined using an ELISA test, and genomic DNA was extracted via the standard phenol/chloroform-based method and genotyped via RFLP-PCR. Results: The CAT level was decreased in NAFLD patients (p < 0.001), and an ROC analysis revealed that a CAT level lower than 473.55 U/L significantly increases the risk of NAFLD. In turn, genotyping showed that the CT genotype and the T allele of -262 C/T CAT polymorphism elevate the risk of NAFLD. The diminished CAT level in the NAFLD group correlated with increased FLI, waist circumference and female gender. Conclusion: The obtained results support observations that oxidative damage associated with NAFLD may be the result of a decreased CAT level as a part of the antioxidant defense system.

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“…The results of a previous study conducted on the same population contradicts our results regarding SOD2 rs4880 expression. 33 However, our study included a healthy control group, leading to differences in inclusion criteria. Furthermore, we validated our results using robust Sanger sequencing.…”

Section: Discussionmentioning

confidence: 99%

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study

Sultan,

Alharbi,

Alrayes

et al. 2023

Endocrino Diabet & Metabol

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IntroductionOne of the complications of diabetes mellitus (DM) is diabetic nephropathy (DN), which plays a significant role in the progression of end‐stage renal disease. Oxidative stress is implicated in DN pathogenesis, and genetic variations in antioxidant enzymes such as superoxide dismutase 2 (SOD2) and catalase (CAT) may contribute to the susceptibility. This study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) in antioxidant enzymes, specifically SOD2 rs4880 and CAT rs769217, and the risk of T2D and susceptibility to DN within the Saudi population.MethodsThis case–control study included 150 participants, comprising 50 patients with T2D without DN (group 1), 50 patients with T2D with DN (group 2), and 50 healthy participants (group 3). The samples were genotyped using real‐time PCR for SOD2 rs4880 and CAT rs769217 SNPs. Sanger sequencing was used for validation. Statistical analyses were performed to explore associations between these SNPs and T2D with or without DN.ResultsNo significant difference was observed in CAT rs769217 expression between the groups. However, a significant difference was observed in SOD2 rs4880 expression between the healthy controls and patients with T2D with DN (p = .028). Furthermore, SOD2 rs4880 was associated with approximately threefold increased risk of DN in patients with T2D compared to that in healthy participants (odds ratio [OR] = 2.99 [1.31–6.83]). Validation through Sanger sequencing further confirmed these findings.ConclusionsThe findings of this study provide evidence that SOD2 rs4880 SNP may contribute to inadequate defence by the antioxidant enzyme, SOD2, against DM‐induced oxidative stress and thus cause DN in Saudi patients with T2D. Therefore, SOD2 rs4880 may serve as a predictive marker to prevent the development and progression of DN in patients with T2D.

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Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus

Cited by 10 publications

References 39 publications

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis

Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study

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