“…In particular, "strenuous" joggers (>4 h/wk at >7 miles/h) displayed a trend toward substantially enhanced risk of all-cause mortality (HR, 9.08; 95% CI: 1.87-44.01) compared with "light" joggers. Notably, data on professional athletes are also contradictory, in that some studies reported a higher risk of premature death, 16,17 while others did not. 18,19 Indeed, other studies suggest a "sweet spot" for PA and subsequent clinical outcomes, with either loss of benefit or worse outcomes at very high doses.…”