Do estrogens improve bone mineral density in osteoporotic women over age 65?

Marx, Christopher W.; Dailey, George; Cheney, Carol; Vint, Vinton C.; Muchmore, Douglas B.

doi:10.1002/jbmr.5650071122

Cited by 40 publications

(1 citation statement)

References 32 publications

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“…Estrogen replacement therapy (ERT) has been a logical and valuable treatment option in the management of postmenopausal osteoporosis. Studies have shown that ERT was able to reduce the risk of fracture in postmenopausal women by preserving BMD and decreasing rate of bone loss 9 . Due to high risk of cancer (breast, colorectal and endometrial) and other serious side effects associated with chronic use of estrogen, ERT has been reserved for management of symptoms of menopause such as hot flashes and vaginal dryness 10 .…”

Section: Introductionmentioning

confidence: 99%

Comparative anti-osteoporotic properties of the leaves and roots of Marantodes pumilum var. alata in postmenopausal rat model

Giaze

Shuid

Soelaiman

et al. 2019

Journal of Traditional and Complementary Medicine

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Background Marantodes pumilum var. alata ( MPva ), popularly known as Kacip Fatimah, is widely used to maintain female reproductive health, facilitate post-partum recovery and manage symptoms of menopause and osteoporosis in South-East Asia. This study aims to further evaluate the osteoprotective potential of MPva in view of reports of its bone-protective properties in postmenopausal condition. Methods Thirty female Sprague-Dawley rats were sorted into 5 groups (n = 6) namely: MPv (leaf treatment); MPr (root treatment); ERT (estrogen treatment); OVXC (untreated ovariectomized control) and Sham (untreated sham-operated control). All rats (except the Sham) were ovariectomized to induce a state of estrogen deficiency that simulates menopause. Two weeks after ovariectomy, the rats were treated for 8 weeks with oral gavages of estrogen and plant extracts. The ERT group received 64.5 μg/kg/day dose of estrogen while MPv and MPr groups received 20 mg/kg/day dose of leaf and root extracts , respectively. At the end of treatment, left femora were excised from euthanized rats and investigated for changes in bone micro-architecture, mineral density, and biomechanical properties. Results Bone volume fraction, degree of anisotropy and structure-model-index of bone were significantly improved ( p < 0.05) in the MPv group compared to OVXC. Breaking force and maximum stress of bone were also significantly higher ( p < 0.05) in the MPv group compared to the OVXC. Conclusion Treatment with MPva leaf protected bone microarchitecture and density against osteoporosis-related changes in postmenopausal rats. Similar to estrogen, the protective effects of MPva leaf translated into better-enhanced bone mechanical properties compared to the root treatment.

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Section: Introductionmentioning

confidence: 99%

Comparative anti-osteoporotic properties of the leaves and roots of Marantodes pumilum var. alata in postmenopausal rat model

Giaze

Shuid

Soelaiman

et al. 2019

Journal of Traditional and Complementary Medicine

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Timing of postmenopausal estrogen for optimal bone mineral density. The Rancho Bernardo Study

Schneider

Barrett‐Connor²,

Morton³

1997

JAMA: The Journal of the American Medical Association

130

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Bone Mineral Density Response to Estrogen Replacement in Frail Elderly Women

Villareal¹,

Binder²,

Williams³

et al. 2001

JAMA

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Context Although hormone replacement therapy (HRT) is an established approach for osteoporosis prevention, little is known about the osteoprotective effects of HRT in frail elderly women. Objective To determine whether HRT increases bone mineral density (BMD) in frail elderly women. Design and Setting Randomized, double-blind, placebo-controlled trial conducted in a US university-based research center from September 1995 to August 2000. Participants Sixty-seven women aged 75 years or older with mild-to-moderate physical frailty. Intervention Participants were randomly assigned to receive conjugated estrogens, 0.625 mg/d, plus trimonthly medroxyprogesterone acetate, 5 mg/d for 13 days (n=45), or matching placebo (n = 22), for 9 months. Main Outcome Measures The primary outcome measure was 9-month change in BMD of the lumbar spine and hip, measured by dual-energy x-ray absorptiometry. Secondary outcomes were changes in markers of bone turnover. Results Based on intention-to-treat analyses, HRT resulted in significantly larger increases in BMD of the lumbar spine than placebo (mean change, 4.3% vs 0.4%; betweengroup difference, 3.9%; 95% confidence interval [CI], 3.5%-4.3%) and total hip (mean change, 1.7% vs −0.1%; between-group difference, 1.8%; 95% CI, 1.5%-2.1%). Compared with placebo, HRT resulted in significant decreases in serum bone-specific alkaline phosphatase levels (mean change, −24% vs 6%; between-group difference, −30%; 95% CI, −26% to −33%) and urine N-telopeptide levels (mean change, −48% vs 4%; between-group difference, −52%; 95% CI, −47% to −55%). Conclusions In physically frail elderly women, 9 months of HRT significantly increased BMD compared with placebo in clinically important skeletal regions. Further studies are needed to determine whether these osteogenic effects of HRT in elderly women are associated with a reduction in osteoporotic fractures.

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Do estrogens improve bone mineral density in osteoporotic women over age 65?

Cited by 40 publications

References 32 publications

Comparative anti-osteoporotic properties of the leaves and roots of Marantodes pumilum var. alata in postmenopausal rat model

Comparative anti-osteoporotic properties of the leaves and roots of Marantodes pumilum var. alata in postmenopausal rat model

Timing of postmenopausal estrogen for optimal bone mineral density. The Rancho Bernardo Study

Bone Mineral Density Response to Estrogen Replacement in Frail Elderly Women

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