Do Different Diagnostic Criteria Impact Polycystic Ovary Syndrome Diagnosis for Adolescents?

Akgül, Sinem; Düzçeker, Yasemin; Kanbur, Nuray; Derman, Orhan

doi:10.1016/j.jpag.2017.12.002

Cited by 19 publications

(33 citation statements)

References 33 publications

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“…Patients were categorized according to 6 different criteria for PCOS. The study shows that the choice of particular guidelines has a great impact on whether an adolescent receives the PCOS diagnosis or not [25].…”

Section: Polycystic Ovary Syndromementioning

confidence: 96%

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty

Otto-Buczkowska

Grzyb

Jainta

2018

Pediatr Endocrino Diabetes Metab

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Polycystic ovary syndrome (PCOS) usually arises during puberty and is marked by insulin resistance, hyperinsulinemia, and hyperandrogenism. The principle is that the diagnosis of PCOS must be based on the presence of at least two of the following three criteria: chronic anovulation, hyperandrogenism (clinical or biological), and polycystic ovaries. The diagnosis of PCOS in adolescents is particularly difficult due to developmental problems in this group. Many symptoms of PCOS, including acne, menstrual irregularities, and hyperinsulinemia, are common in normal puberty. Adolescents with PCOS are at an increased risk of developing health problems later on in life, such as diabetes, cardiovascular disease, and infertility. One should reckon with the frequent occurrence of the PCOS in type 1 diabetes, when the ovaries and the adrenals are exposed to excessive insulin concentrations. Ovarian hyperandrogenism is common in adolescent girls with type 1 diabetes. Methods of treatment for an adolescent with PCOS include diet and exercise. Metformin is commonly used in young girls and adolescents with PCOS as first-line monotherapy or in combination with anti-androgen medications. StreszczenieZespół policystycznych jajników (PCOS) zwykle pojawia się w okresie dojrzewania i charakteryzuje się występowaniem insulinooporności, hiperinsulinemii i hiperandrogenizmu. Przyjęta jest zasada, że diagnoza PCOS musi opierać się na obecności co najmniej dwóch z trzech następujących kryteriów: przewlekłego braku owulacji, hiperandrogenizmu (klinicznego lub biologicznego) i policystycznych jajników. Rozpoznanie PCOS u nastolatek jest szczególnie trudne. Wiele objawów PCOS, w tym trądzik, zaburzenia miesiączkowania i hiperinsulinemia, są częste w okresie dojrzewania. U nastolatek z PCOS istnieje zwiększone ryzyko wystąpienia problemów zdrowotnych w późniejszym życiu, takich jak cukrzyca, choroby sercowo-naczyniowe i niepłodność. Należy liczyć się z częstym występowaniem PCOS w cukrzycy typu 1, gdy jajniki i nadnercza są narażone na nadmierne stężenia insuliny. Hiperandrogenizm pochodzenia jajnikowego występuje często u nastolatek z cukrzycą typu 1. Leczenie młodzieży z PCOS obejmuje dietę i ćwiczenia fizyczne. Metformina jest powszechnie stosowana u młodych dziewcząt z PCOS w monoterapii pierwszego rzutu lub w połączeniu z lekami przeciwandrogenowymi. Słowa kluczowe hiperandrogenizm, zespół policystycznych jajników, insulinooporność, cukrzyca

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Section: Polycystic Ovary Syndromementioning

confidence: 96%

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty

Otto-Buczkowska

Grzyb

Jainta

2018

Pediatr Endocrino Diabetes Metab

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“…Fasting glucose, glycated hemoglobin (HbA1c), and lipid concentrations are also typically requested. 12,13 The first criteria by the National Institute of Health (NIH) in 1990 established a PCOS diagnosis based on the presence of both clinical and/or biochemical hyperandrogenism and menstrual irregularity. 7 The Rotterdam criteria were developed in 2003 and further reformulated in 2004.…”

Section: Diagnosismentioning

confidence: 99%

“…7 The Rotterdam criteria were developed in 2003 and further reformulated in 2004. 7,13 In 2006, the Androgen Excess Society (AES) came up with refined criteria. 7 Since there is a considerable convergence between normal pubertal milestones (such as acne, irregular menses, and polycystic ovaries) and PCOS phenotypes, experts considered the ahead criteria (NIH, Rotterdam and AES criteria) led to an overdiagnosis within this age group.…”

Section: Diagnosismentioning

confidence: 99%

“…1 Therefore, several societies started including adolescents as a specific group within their guidelines for the diagnosis of PCOS. 7,10,13 The Amsterdam criteria, in 2012, was the first official consensus directed toward the specificities of adolescents, 13,14 followed by the Endocrine Society (ES) guidelines in 2013 13 and by an adolescent-specific expert consensus by the Pediatric Endocrine Society (PES) in 2015. 13,15 Also in 2015, the American Association of Clinical Endocrinologists (AACE), together with the American College of Endocrinology (ACE), the AES, and other PCOS societies created a practical guideline for evaluation and work-up of PCOS in this age group.…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management

Manique

Póvoa

2022

Rev Bras Ginecol Obstet

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Diagnosing polycystic ovary syndrome (PCOS) during adolescence is challenging since normal pubertal development overlap typical features of this syndrome. The authors aim to summarize the existing evidence concerning PCOS in adolescence, particularly its diagnostic criteria and therapeutic options. A search throughout medical databases such as PubMed and MedScape was performed. Diagnostic criteria include irregular menstrual cycles according to time postmenarche and evidence of clinical hyperandrogenism and/or biochemical hyperandrogenism, provided other causes have been excluded. Polycystic ovarian morphology ought not to be used as a diagnostic criterion. Treatment should target manifestations and/or comorbidities, even in the absence of a definite diagnosis. Lifestyle interventions are the first-line treatment. Combined oral contraceptives, metformin or antiandrogens may also be considered as adjuvants. Screening for PCOS in adolescence is crucial as it allows an early intervention on the symptoms and comorbidities presented leading to better long-term reproductive and metabolic outcomes.

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“…Ultrasound criteria are not utilized in adolescents due to lack of age-specific normative data and cut-off values. The adolescent guidelines for making a diagnosis of PCOS are more specific but potentially less sensitive, thus requiring careful follow up over time in girls that do not fully meet criteria at initial evaluation [4,5,6].…”

Section: Diagnosis and Management Of Pcosmentioning

confidence: 99%

Emerging Topics in Cardiometabolic and Psychologic Sequelae, Pathogenesis, and Treatment of Polycystic Ovarian Syndrome: A Review

Shah

2019

Children

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Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, affecting 6–10% of reproductive age women and influences the reproductive, metabolic, dermatologic, and psychiatric health of affected girls and women. Despite its prevalence, the pathogenesis of the disease is largely unknown, and treatment options are limited. Thus, PCOS has been a ripe area for research in recent years, and novel etiologic pathways, diagnostic parameters, and treatment options are being explored. This review focuses on recent data suggesting pathogenic and therapeutic considerations, as well as the psychiatric and metabolic sequelae of PCOS.

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Do Different Diagnostic Criteria Impact Polycystic Ovary Syndrome Diagnosis for Adolescents?

Cited by 19 publications

References 33 publications

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty

Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management

Emerging Topics in Cardiometabolic and Psychologic Sequelae, Pathogenesis, and Treatment of Polycystic Ovarian Syndrome: A Review

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