Do chronic noncommunicable diseases modify the macronutrient composition of human milk?

Amaral, Yasmin Notarbartolo di Villarosa do; Marano, Daniele; Abranches, Andrea Dunshee de; Silva, Leila; Nehab, Sylvia Reis Gonçalves; Costa, Ana Carolina da; Moreira, Maria Elisabeth Lopes

doi:10.1080/09637486.2020.1780568

Cited by 3 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fujimori et al (2015) [ 19 ] and Amaral et al (2021) [ 20 ] observed that women were pregestational overweight had higher levels of fat and energy in the colostrum, with no differences in protein content between overweight and eutrophic women. Dritsakou et al (2017) [ 10 ] also found higher levels of fat and energy in colostrum and transition milk of overweight women.…”

Section: Discussionmentioning

confidence: 99%

What Are the Maternal Factors that Potentially Intervenes in the Nutritional Composition of Human Milk?

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: To evaluate the potential factors associated with the nutritional composition of human milk of puerperal women. Methods: cross-sectional study, conducted between March 2016 and August 2017, with 107 women, selected in a Tertiary Health Care Tertiary Health Facility of the Unified Health System (SUS) in the Municipality of Rio de Janeiro. Data were collected two months after delivery. The dependent variable of the study was the nutritional composition of human milk. We divided the independent variables into hierarchical levels: distal (age, schooling, parity and pregestational nutritional status), intermediate (number of prenatal visits and gestational weight gain) and proximal (alcohol consumption, smoking, diabetes mellitus and hypertension). For data analysis, we applied the multiple linear regression, centered on the hierarchical model. Only the variables associated with the nutritional composition of breast milk remained in the final model at a 5% level of significance. Results: The nutritional composition of human milk yielded by women with pregestational overweight, smokers and hypertensive had higher amounts of lipids and energy. Conversely, women with gestational weight gain below the recommended had lower amounts of these components. Conclusion: The evaluation of factors associated with the nutritional composition of human milk is extremely important to assist post-partum care practices. In this study, we observed that lipid and energy contents were associated to pregestational nutritional status, gestational weight gain, smoking and hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

What Are the Maternal Factors that Potentially Intervenes in the Nutritional Composition of Human Milk?

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, by analysing the evolutional changes in human milk in correlation to each OIL group (healthy vs. moderate/severe groups), we found that the concentrations of EPA, one of the essential n-3 LCPUFAs, decreased in the milk of mothers with moderate to severe OIL during lactation compared to mothers with healthy OIL after adjusting for confounding variables. Regarding the association between maternal chronic diseases and the FA composition of human milk, studies in the literature have investigated the possible influence of elevated body weight, diabetes mellitus, allergic diseases, and arterial hypertension on the FA content of human milk [ 32 ]. In as much as the former conditions can be considered inflammatory in nature, the findings reported here comport with those reported in the previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that there is a bidirectional relationship between maternal and infant health. Studies have also shown that the lipid content in human milk varies in the presence of several maternal health conditions, including but not limited to diabetes [ 28 ], obesity [ 29 ], and allergic diseases [ 30 , 31 ], which consequently affects the nutritional status and future health of the infant [ 32 ]. While studies have reported an association between maternal and infant infections and hmPMN counts and FAs content in human milk, the impact of maternal oral/periodontal inflammation on human milk composition is unknown.…”

Section: Introductionmentioning

confidence: 99%

The Association between Maternal Oral Inflammation and Neutrophil Phenotypes and Poly-Unsaturated Fatty Acids Composition in Human Milk: A Prospective Cohort Study

Badewy

Azarpazhooh

Tenenbaum

et al. 2022

Cells

View full text Add to dashboard Cite

This prospective cohort study aimed to investigate the impact of maternal oral inflammation on human milk composition including neutrophil counts, activation state (based on cluster of differentiation (CD) markers expression), and fatty acid levels. Fifty mothers were recruited from St. Michael’s hospital, Toronto, and followed up from 2–4 weeks until 4 months postpartum. Oral rinse and human milk samples were collected at both timepoints. Oral polymorphonuclear neutrophils (oPMNs) within the rinses were quantified using flow cytometry and the participants’ oral health state was categorized into three groups (i.e., healthy, moderate, and severe) based on the oPMNs counts. Fatty acids were identified and quantified using a gas chromatography-flame ionization detector (GC-FID). Compared to mothers with a healthy oral health state, mothers with moderate to severe oral inflammation had a statistically significant decrease in the expression of CD64 biomarker, an increase in the expression of CD14 biomarker on human milk neutrophils and a decrease in the levels of eicosapentaenoic acid (C20:5n-3) in their human milk at follow-up compared to baseline. This study demonstrates for the first time that maternal oral inflammation can affect human milk composition. The mechanism by which these alterations can affect infant health outcomes in the long term critically needs to be considered.

show abstract

Evaluation of Breast Milk Macronutrient Content in Preeclamptic Mothers

Beşer

Çetinkaya

Şimşek

et al. 2022

Breastfeeding Medicine

View full text Add to dashboard Cite

Do chronic noncommunicable diseases modify the macronutrient composition of human milk?

Cited by 3 publications

References 32 publications

What Are the Maternal Factors that Potentially Intervenes in the Nutritional Composition of Human Milk?

What Are the Maternal Factors that Potentially Intervenes in the Nutritional Composition of Human Milk?

The Association between Maternal Oral Inflammation and Neutrophil Phenotypes and Poly-Unsaturated Fatty Acids Composition in Human Milk: A Prospective Cohort Study

Evaluation of Breast Milk Macronutrient Content in Preeclamptic Mothers

Contact Info

Product

Resources

About