Do Back Support Belts Cause Gastroesophageal Reflux?

Abstract

A competent lower esophageal sphincter (LES) prevents gastroesophageal reflux disease (GERD) in the setting of increased abdominal pressure. Therefore, we have assessed whether a back support belt causes gastroesophageal reflux (GER). Ten healthy volunteers underwent esophageal manometric studies to locate the LES. Subsequently, each subject underwent two separate 8-hour intra-esophageal pH monitor studies on different days, the first without wearing a back support belt, and the subsequent one wearing a back support belt. A symptom diary and continuous intra-esophageal pH data were obtained during both study periods. The mean LES pressure (LESP) was 14 +/- 3.6 mm Hg without a back support belt and 15.8 +/- 4.3 mm Hg with a back support belt which was not significantly different. There were no significant differences in total episodes of GER, esophageal acid exposure, or any other parameters monitored. Symptoms of GER were the same comparing the back support belt with no back support belt. We conclude that healthy people with normal LESP do not have increased GER as a result of wearing a back support belt.

Expression of Cyclooxygenase-2, p53 and Ki-67 in Gastric Cancer

“…This result was concordant with result obtained by Yamagishi et al (22). Also, Sawaoka et al reported that both selective and non-selective COX-2 inhibitors exerted minimal effects on cell proliferation of human gastric cancer cell lines, which expressed lower levels of COX-2, but suppressed cell proliferation of human gastric cancer cell lines that overexpressed COX-2 (23). These results imply that COX-2 play a critical role in tumor cell proliferation of gastric cancer.…”