2006
DOI: 10.5483/bmbrep.2006.39.2.171
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Preliminary Proteomic Analysis of Indomethacin's Effect on Tumor Transplanted with Colorectal Cancer Cell in Nude Mice

Abstract: Nonsteroidal anti-inflammatory drugs such as indomethacin (IN) can exert anti-colorectal cancer (CRC) activity through cyclooxygenase independent mechanism, but the exactly biological mechanism is not completely known. Here we use proteomic tools to investigate the molecular mechanism of this action. First, nude mice bearing tumors derived from subcutaneous injection with human CRC cell line HCT116 were randomly allocated to groups treated with or without indomethacin. Later, tumor lumps were incised and then … Show more

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Cited by 7 publications
(14 citation statements)
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“…Tissue 2D-GE [145] Aldolase A + Tissue 2D-GE [146] Aldolase C, fructose-biphosphate + Tissue 2D-GE [37] Aldolase, fructose-biphosphate + Tissue 2D-GE [20] [ 36] Cell line 2D-DIGE -Cell line 2D-GE [36] NR Tissue 2D-GE [140] α-1 antitrypsin precursor…”
Section: D-digementioning
confidence: 99%
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“…Tissue 2D-GE [145] Aldolase A + Tissue 2D-GE [146] Aldolase C, fructose-biphosphate + Tissue 2D-GE [37] Aldolase, fructose-biphosphate + Tissue 2D-GE [20] [ 36] Cell line 2D-DIGE -Cell line 2D-GE [36] NR Tissue 2D-GE [140] α-1 antitrypsin precursor…”
Section: D-digementioning
confidence: 99%
“…Tissue 2D-GE [22,142,147] 2D-DIGE α-3 type VI collagen, isoform 2 precursor + Tissue 2D-GE [146] α-1B glycoprotein -Tissue 2D-GE [143] α(B)-crystallin -Tissue 2D-GE [145] α-defensins (human neutrophil peptide) 1-3 + Tissue SELDI-TOF MS [57][58][59] serum Annexin I (A1) + Tissue 2D-GE [37] [142] 2D-DIGE Annexin A2 (Annexin II) + Tissue 2D-GE [140,146] [ 141,148] Cell line…”
Section: D-digementioning
confidence: 99%
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“…Candidate protein spots were cut off from the gels and extracted by in gel digestion as described by Wang et al (27). The generated peptides were analyzed by MALDI-TOF-MS us-http://bmbreports.org ing a Bruker Daltonics AutoFlex TOF-TOF LIFT mass spectrometer (Germany).…”
Section: In-gel Digestion Of Protein Mass Spectrometry (Ms)mentioning
confidence: 99%