Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure?

Smeets, E.; Schutzler, Scott; Wei, Jeanne Y.; Azhar, Gohar; Wolfe, Robert R.

doi:10.14814/phy2.13366

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Although post-prandial nutritional absorption influences growth hormone (GH) secretion, the nutrients responsible for regulating this secretion are not clear. 50 The enterocytes lining the small intestinal tract have rapid turnover and are highly metabolic, scavenging a large proportion of dietary amino acids. This suggests that the chronic and long-lasting effects in these TBI patients are not quickly overcome and can lead to comorbidities long after the initial injury.…”

Section: Discussionmentioning

confidence: 99%

Altered Fecal Microbiome Years after Traumatic Brain Injury

Urban

Pyles

Stewart

et al. 2020

Journal of Neurotrauma

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Patients with chronic traumatic brain injury (TBI) requiring long-term, permanent care suffer a myriad of clinical symptoms (i.e., impaired cognition, fatigue, and other conditions) that persist for years beyond the acute brain injury. In addition to these comorbid clinical symptoms, chronic TBI patients exhibit altered amino acid and hormonal profiles with distinct cytokine patterns suggesting chronic inflammation. This metabolic link suggests a role of the gut-brain axis in chronic TBI. Thus, we utilized a two-site trial to investigate the role of the gut-brain axis in comorbidities of chronic TBI. The fecal microbiome profile of 22 moderate/severe TBI patients residing in permanent care facilities in Texas and California was compared to 18 healthy age-matched control subjects working within the participating facilities. Each fecal microbiome was characterized by 16S(V4) ribosomal RNA (rRNA) gene sequencing and metagenomic genome sequencing approaches followed by confirmatory full 16S rRNA gene sequencing or focused tuf gene speciation and specific quantitative polymerase chain reaction evaluation of selected genera or species. The average chronic TBI patient fecal microbiome structure was significantly different compared to the control cohort, and these differences persisted after group stratification analysis to identify any unexpected confounders. Notably, the fecal microbiome of the chronic TBI cohort had absent or reduced Prevotella spp. and Bacteroidies spp. Conversely, bacteria in the Ruminococcaceae family were higher in abundance in TBI compared to control profiles. Previously reported hypoaminoacidemia, including significantly reduced levels of l-tryptophan, l-sarcosine, ß-alanine, and alanine, positively correlated with the reduced levels of Prevotella spp. in the TBI cohort samples compared to controls. Although the sequelae of gut-brain axis disruption after TBI is not fully understood, characterizing TBI-related alterations in the fecal microbiome may provide biomarkers and therapeutic targets to address patient morbidity.

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Section: Discussionmentioning

confidence: 99%

Altered Fecal Microbiome Years after Traumatic Brain Injury

Urban

Pyles

Stewart

et al. 2020

Journal of Neurotrauma

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“…Aging is related to a decline in the endocrine system. In recent years, accumulating evidence suggests the therapeutic role of GH, DHEA-S, and estrogen in elderly women [52,53,54]. A deficiency of GH during aging increases adiposity and decreases LBM [55].…”

Section: Discussionmentioning

confidence: 99%

The Effects of 12 Weeks of a Combined Exercise Program on Physical Function and Hormonal Status in Elderly Korean Women

Im¹,

Bang

Seo

2019

IJERPH

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Aging causes a decline in physical function and hormonal balance. Exercise can improve these parameters. However, the beneficial effects of a combined exercise program (Korean dance and yoga) on physical function and hormonal status in elderly women remain unknown. This study aims to investigate the effects of a 12-week combined exercise program on balance, flexibility, muscle strength, and hormonal status in elderly Korean women. Twenty-five healthy elderly women were recruited and randomly divided into the control (CON) and exercise (EXE) groups. The EXE group underwent the combined exercise program (60 min/day and 3 times/week) for 12 weeks. The two groups did not differ in body weight, lean body mass, fat mass, body fat percentage, or body mass index at baseline or in the changes following the experimental conditions. A significant time × group interaction was detected for anterior and posterior dynamic balance, static balance, and growth hormone (GH). After the combined exercise program, anterior dynamic balance, posterior dynamic balance, static balance, flexibility, muscle strength, GH, dehydroepiandrosterone-sulfate, and estrogen significantly increased in the EXE group compared to the CON group. In conclusion, the combined exercise program contributed to improvements in overall health, including physical function and hormonal status, in elderly Korean women.

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