Do Adult Forms of Chronic Rhinosinusitis Exist in Children and Adolescents?

Hopp, Russell J.

doi:10.3390/sinusitis2040007

Cited by 3 publications

(3 citation statements)

References 44 publications

(70 reference statements)

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“…A reasonable place to initiate this discussion is a list of the manuscripts on pediatric rhinosinusitis (CRS) in the recent past, which will serve as backdrop to the lingering issues in pediatric CRS [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Chronic Rhinosinusitis: Unmet Needs

Hopp

2020

Sinusitis

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Pediatric chronic rhinosinusitis (CRS) remains an elusive diagnostic medical condition, largely based on imperfect diagnostic criteria, lack of controlled studies of therapy, lack of measure for resolution, and lack of information of pediatric sinus microbiome dysbiosis. The true prevalence of pediatric CRS is unknown, and symptoms often over-lap with other diagnoses. We review the unmet needs in pediatric CRS, to highlight potential research opportunities to improve understanding and therapy of the disease process.

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Section: Introductionmentioning

confidence: 99%

“…Fungal sinusitis has been recently reviewed in UpToDate, and is not included [13]. Adolescents with polyps and aspirin exacerbation of respiratory disease are exceedingly rare, and are not discussed here, but have had a recent review [2,14].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Chronic Rhinosinusitis: Unmet Needs

Hopp

2020

Sinusitis

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“…Pediatric chronic rhinosinusitis (CRS) is a persistent and heterogenous inflammatory disease of paranasal sinuses, with a prevalence of around 5–15% in children [ 1 , 2 , 3 ]. CRS is generally defined by the presence of two or more symptoms of facial pain/pressure, nasal congestion, nasal drainage, cough, hyposmia/anosmia, or cough over three months [ 4 , 5 ] and confirmed by nasal endoscopy and/or CT scan [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of Microbial Diversity with Age and Other Clinical Variables among Pediatric Chronic Rhinosinusitis (CRS) Patients

et al. 2023

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Chronic rhinosinusitis (CRS) is a heterogenous disease that causes persistent paranasal sinus inflammation in children. Microorganisms are thought to contribute to the etiology and progression of CRS. Culture-independent microbiome analysis offers deeper insights into sinonasal microbial diversity and microbe–disease associations than culture-based methods. To date, CRS-related microbiome studies have mostly focused on the adult population, and only one study has characterized the pediatric CRS microbiome. In this study, we analyzed the bacterial diversity of adenoid tissue, adenoid swab, maxillary sinus, and sinus wash samples from 45 pediatric CRS patients recruited from the Johns Hopkins All Children’s Hospital (JHACH) in St Petersburg, FL, USA. The alpha diversity in these samples was associated with baseline nasal steroid use, leukotriene receptor antagonist (LTRA) use, and total serum immunoglobulin (Ig) E (IgE) level. Streptococcus, Moraxella, and Haemophilus spp. were most frequently identified from sinus cultures and the sequenced 16S rRNA gene content. Comparative analyses combining our samples with the samples from the previous microbiome study revealed differentially abundant genera between patients with pediatric CRS and healthy controls, including Cutibacterium and Moraxella. Additionally, the abundances of Streptobacillus and Staphylococcus were consistently correlated with age in both adenoid- and sinus-derived samples. Our study uncovers new associations of alpha diversity with clinical parameters, as well as associations of specific genera with disease status and age, that can be further investigated.

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A mini-update on chronic rhinosinusitis

Darougar,

Hematyar,

Savoji

2024

Explor Asthma Allergy

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Chronic rhinosinusitis (CRS) is an inflammatory disorder of the paranasal sinuses and the nasal cavity lasting longer than 12 weeks. This disease is a common clinical syndrome with significant monetary burden due to the high costs of medical visits, diagnostic tests, medications, and surgical therapies. CRS without nasal polyposis (CRSsNP) is the most common subtype of CRS, accounting for about 70% of all patients. Other subtypes include CRS with nasal polyposis (CRSwNP) and allergic fungal rhinosinusitis (AFRS). CRSwNP has the worldwide prevalence of 2% to 4% and is often accompanied by type 2 inflammation and asthma as a comorbid condition. Pediatric chronic sinusitis is distinct from adult chronic sinusitis and is currently considered an infectious process, characterized by persistent inflammation representing an exaggerated immune response to an external stimulus. The medical and surgical management of CRS has been remarkably modified in the past two decades. The aim of this study was to present an update on CRS based on the recent years’ literature.

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Do Adult Forms of Chronic Rhinosinusitis Exist in Children and Adolescents?

Cited by 3 publications

References 44 publications

Pediatric Chronic Rhinosinusitis: Unmet Needs

Pediatric Chronic Rhinosinusitis: Unmet Needs

Associations of Microbial Diversity with Age and Other Clinical Variables among Pediatric Chronic Rhinosinusitis (CRS) Patients

A mini-update on chronic rhinosinusitis

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