2005
DOI: 10.1007/s00018-005-4570-0
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DNG1, a Dictyostelium homologue of tumor suppressor ING1 regulates differentiation of Dictyostelium cells

Abstract: dng1 is a Dictyostelium homologue of the mammalian tumor suppressor ING gene. DNG1 protein localizes in the nucleus, and has a highly conserved PHD finger domain found in chromatin-remodeling proteins. Both dng1 disruption and overexpression impaired cell proliferation. In dng1-null cells, the progression of differentiation was delayed in a cell-density-dependent manner, and many tiny aggregates were formed. Exogenously applied cAMP pulses reversed the inhibitory effect caused by dng1 disruption on the aggrega… Show more

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Cited by 6 publications
(7 citation statements)
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“…2000). Similarly, a recent report on DNG1, a Dictyostelium homologue of the tumor suppressor ING1, shows that dng1 ‐null cells express a much reduced level of csA/gp80 and form very small aggregates (Mayanagi et al. 2005).…”
Section: Regulation Of Temporal Expression Of Camsmentioning
confidence: 80%
“…2000). Similarly, a recent report on DNG1, a Dictyostelium homologue of the tumor suppressor ING1, shows that dng1 ‐null cells express a much reduced level of csA/gp80 and form very small aggregates (Mayanagi et al. 2005).…”
Section: Regulation Of Temporal Expression Of Camsmentioning
confidence: 80%
“…A recent commentary regarding the function of PHD fingers reiterated that the interaction of the PHD motif with methylated histone tails is not the primary mode of transcriptional regulation, but rather augments the interface of co-factors and chromatin remodeling complexes upon their recruitment to target promoters. (65) Chromatin remodeling via PHD fingers appears to be an evolutionarily conserved function, as ablation results in loss of histone modifications and improper transcriptional control from plants (76) to mammals. (77) Alterations to the chromatin modifying and transcriptional functions of PHD proteins are implicated in human diseases.…”
Section: Resultsmentioning
confidence: 99%
“…Also, the only other treatment that rescued the developmental delay itself was mixing wild-type cells with the tert KO cells at a 1:1 ratio (Fig 18; Table 2). Even though caffeine and glucose rescued streaming and mound size, and apparently this was at least partly mediated via their impact on cAMP-regulated processes, neither of the compounds rescued the delay, even though abnormalities of cAMP-regulated processes are commonly reported causes of delay in other Dictyostelium studies [5254].…”
Section: Resultsmentioning
confidence: 99%
“…A line ending in an arrowhead suggests that the first element directly or indirectly promotes the activity or levels of the second; inhibition is suggested by a line ending in a cross-bar. Published works that report on the nature of each pathway within the network are as follows: a[29], [40]; b[29]; c[66]; d[52], [53], [54]; e[61], [82], [83], [84]; f[85]; g [86], [87]; h[88–90]; i[91], [33]; j[77]; k[92], [93], [94]; l[26], [39]; m[27]; n[35]; o[95], [96]; p[67]; q[67], [75]; r[67]; s[97]; t[75]; u[65]; v[98], [39]; w[99], [100]; x[66]; y[101].…”
Section: Introductionmentioning
confidence: 99%