DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy

Wang, Huimin; Chen, Yuqi; Wang, Hong; Liu, Xiaoqing; Zhou, Xiang; Wang, Fuan

doi:10.1002/ange.201902714

Cited by 72 publications

(18 citation statements)

References 43 publications

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“…(d) The expression of the early growth response protein‐1 (EGR‐1) in MCF‐7 cells with different treatments (a: PBS, b: cDNA@ZIF‐8, c: free DNAzyme, d: DNAzyme@ZIF‐8). (e) Detection of intracellular ROS generation in MCF‐7 cells using the DCFH‐DA probe under laser (660 nm) only, with Ce6‐cDNA@ZIF‐8 treatment, and with laser (660 nm) + Ce6‐cDNA@ZIF‐8 treatment [reprinted with permission from Wang, Chen, et al, 2019, Copyright 2019 Wiley‐VCH]. (f) Schematic of coordination‐driven self‐assembled metal–organic nanostructures of R‐nanoICG/siRNA.…”

Section: Mof‐based Nucleic Acid Therapy In Combination With Other Tre...mentioning

confidence: 99%

“…Wang et al developed a MOF‐based Ce6–DNAzyme therapeutic nanosystem for combined gene therapy and PDT (Figure 2b,c; Wang, Chen, et al, 2019). In this study, the selected MOF ZIF‐8 delivered nucleic acid drugs and the PS Ce6 to the tumor site through passive targeting and also protected against drug degradation.…”

Section: Mof‐based Nucleic Acid Therapy In Combination With Other Tre...mentioning

confidence: 99%

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Combinational application of metal–organic frameworks‐based nanozyme and nucleic acid delivery in cancer therapy

Lin

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

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The rapid development of nanotechnology has generated numerous ideas for cancer treatment, and a wide variety of relevant nanoparticle platforms have been reported. Metal–organic frameworks (MOFs) have been widely investigated as an anti‐cancer drug delivery vehicle owing to their unique porous hybrid structure, biocompatibility, structural tunability, and multi‐functionality. MOF materials with catalytic activity, known as nanozymes, have applications in photodynamic and chemodynamic therapy. Nucleic acids have also attracted increasing research attention owing to their programmability, ease of synthesis, and versatility. A variety of functional DNAs and RNAs have been applied both therapeutically (gene‐targeting drugs for cancer treatment) and nontherapeutically (used as modified materials to enhance the therapeutic effects of other nanomedicines). The combined use of MOFs and functional nucleic acids have been extensively investigated and has been associated with excellent tumor‐suppressor activity in various treatment methods. In this review, we summarize the progress in the research and development of tumor therapy based on MOFs and nucleic acid delivery over recent years, focusing on the combinational use of different delivery and design strategies for MOF/therapeutic nucleic acid platforms. We further summarize the strategies for combining MOFs (universal carrier, functional carrier) and nucleic acids (therapeutic nucleic acids, nontherapeutic nucleic acids) and discuss the corresponding therapeutic effects in cancer treatment. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Mof‐based Nucleic Acid Therapy In Combination With Other Tre...mentioning

confidence: 99%

Section: Mof‐based Nucleic Acid Therapy In Combination With Other Tre...mentioning

confidence: 99%

Combinational application of metal–organic frameworks‐based nanozyme and nucleic acid delivery in cancer therapy

Lin

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

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“…nMOFs are a relatively new class of hybrid porous materials composed of metal ions or clusters bridged by organic ligands, which have ordered pore structure, large specific surface area, and abundant modification sites (41). Therefore, nMOFs hold great potential as drug transport carriers since they can achieve extremely high drug loading capacity (LC) and connect with different molecules as needed to fulfill various functions (42)(43)(44). Moreover, the reversible coordination between ligands and metal ions inside endow the nMOFs with the characteristics of controlled releasing, biodegradability, low toxicity, and good biocompatibility (45).…”

Section: Introductionmentioning

confidence: 99%

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

et al. 2022

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Oral protein delivery is considered a cutting-edge technology to improve patients’ quality of life, offering superior patient compliance and convenience compared with injections. However, oral protein formulation has stagnated because of the instability and inefficient penetration of protein in the gastrointestinal tract. Here, we used acid-resistant metal-organic framework nanoparticles (UiO-68-NH 2 ) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery. The UiO-68-NH 2 nanocarrier with proper pore size achieved high insulin loading while protecting insulin from acid and enzymatic degradation. Through receptor-mediated transcellular pathway, the transferrin-coated nanoparticles realized efficient transport across the intestinal epithelium and controlled insulin release under physiological conditions, leading to a notable hypoglycemic effect and a high oral bioavailability of 29.6%. Our work demonstrates that functional metal-organic framework nanoparticles can protect proteins from the gastric environment and overcome the intestinal barrier, thus providing the possibility for oral biomacromolecule delivery.

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“…13,14 However, sole ZIF-8 nanoparticles do not have the unique properties of inorganic nanoparticles (fluorescence, magnetic resonance, photoacoustic, Raman), which limits their further application in biomedical fields. 15,16 It is worth noting that nanocomposites based on ZIF-8 and inorganic nanoparticle synthesis have been widely used in the imaging and treatment of cancer. 17−21 With the increasing demand for multifunctional imaging and therapy, existing ZIF-8 composite nanomaterials have not met the requirements.…”

Section: ■ Introductionmentioning

confidence: 99%

pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy

Qin

Peng

et al. 2019

ACS Appl. Mater. Interfaces

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A multifunctional diagnosis and treatment integration platform is crucial in cancer treatments. Here, we show that by integrating Gd-doped silicon nanoparticles (Si− Gd NPs), chlorine e6 (Ce6), doxorubicin (DOX), zeolitic imidazolate framework-8 (ZIF-8), poly(2-(diethylamino)ethyl methacrylate) polymers (HOOC-PDMAEMA-SH), and folic acid−poly(ethylene glycol)−maleimide (MaL−PEG−FA) into one single nanoplatform by a self-assembly method, novel multifunctional MOFs (named FZIF-8/DOX−PD−FA) are synthesized with great biocompatibility and tumor targeting as well as pH responsiveness and no drug leakage for drug delivery. In the design, Si−Gd NPs and Ce6 embedded in the nanocomposites are used for magnetic resonance and fluorescence dual-modal imaging, respectively. DOX loaded by the FZIF-8/DOX−PD−FA porous structure is used for chemotherapy, while Ce6 is excited by near-infrared radiation (NIR) for photodynamic therapy. In addition, the pH-responsive ability of HOOC-PDMAEMA-SH to effectively prevent drug leakage is demonstrated by drug release studies in vitro. From the results of confocal microscopy imaging in vitro and fluorescence/magnetic resonance imaging in vivo, FZIF-8/DOX−PD−FA showed a targeting effect on MCF-7 cancer cells. More importantly, the results of treatment experiments on tumor-bearing mice showed that the tumor volume of the FZIF-8/DOX−PD−FA + NIR group is decreased the most compared to the original volume. Owing to the unique dual-modal imaging capability and excellent chemo-/photodynamic combinational cancer therapy effect, the present hybrid nanocarrier provides a new research platform for a new generation of theranostic nanoparticles.

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DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy

Cited by 72 publications

References 43 publications

Combinational application of metal–organic frameworks‐based nanozyme and nucleic acid delivery in cancer therapy

Combinational application of metal–organic frameworks‐based nanozyme and nucleic acid delivery in cancer therapy

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy

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