DNA typing of HLA-A, -C, -B, AND -DRB1 in the children with autism in the Republic of Macedonia

Trajkovski, Vladimir; Спироски, Мирко

doi:10.4149/bll_2015_003

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…Among HLA-DRB alleles, we only demonstrated over-presentation of DRB1*01 in ASD patients compared with controls but 95% CI values include OR =1, which disapproves the results. HLA-DRB1*01 has been previously shown to be associated with rheumatoid arthritis in Syrian population16 and with ASD in Macedonia 17. Although we could not detect any association between DRB1*04 allele and ASD, the role of this allele in ASD susceptibility has been shown in multiple studies.…”

Section: Discussioncontrasting

confidence: 80%

Association of HLA alleles with autism

Sayad

Akbari

Noroozi

et al. 2018

NDT

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BackgroundAutism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis.MethodsAmong them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls.ResultsAfter Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population.ConclusionFuture studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.

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Section: Discussioncontrasting

confidence: 80%

Association of HLA alleles with autism

Sayad

Akbari

Noroozi

et al. 2018

NDT

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“…Several studies have revealed links between HLA and ASD, where autistic children were found to have a higher frequency of HLA-DRB1*11 allele and lower frequency of HLA-DRB1*03 allele [ 40 ]. Several other investigators reported on an association between HLA and ASD in different populations including Caucasian [ 41 – 45 ], Thai [ 46 ], Saudi Arabian [ 47 ], and Chinese [ 48 ]. An interesting association of HLA-G polymorphism with ASD, likely a consequence of prenatal immune activation, was reported by Guerini et al [ 49 ].…”

Section: Immunological Background Of Asdmentioning

confidence: 99%

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Gładysz¹,

Krzywdzińska²,

Hozyasz³

2018

Mol Neurobiol

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Autism spectrum disorders (ASD) are characterized by impairments in language and communication development, social behavior, and the occurrence of stereotypic patterns of behavior and interests. Despite substantial speculation about causes of ASD, its exact etiology remains unknown. Recent studies highlight a link between immune dysfunction and behavioral traits. Various immune anomalies, including humoral and cellular immunity along with abnormalities at the molecular level, have been reported. There is evidence of altered immune function both in cerebrospinal fluid and peripheral blood. Several studies hypothesize a role for neuroinflammation in ASD and are supported by brain tissue and cerebrospinal fluid analysis, as well as evidence of microglial activation. It has been shown that immune abnormalities occur in a substantial number of individuals with ASD. Identifying subgroups with immune system dysregulation and linking specific cellular immunophenotypes to different symptoms would be key to defining a group of patients with immune abnormalities as a major etiology underlying behavioral symptoms. These determinations would provide the opportunity to investigate causative treatments for a defined patient group that may specifically benefit from such an approach. This review summarizes recent insights into immune system dysfunction in individuals with ASD and discusses the potential implications for future therapies.Electronic supplementary materialThe online version of this article (10.1007/s12035-017-0822-x) contains supplementary material, which is available to authorized users.

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“…Hence, it is believed that understanding these alterations will help us to identify ASD in an early stage and initiate a better treatment. alleles were selected in another study, but none of these alleles showed consistent results (16). Al-Hakbany et al (28) could only find HLA-B * 07 significantly associated with ASD in his case-control study, the extended haplotype HLA-A * 02-B * 07 was significantly higher in ASD compared to controls.…”

Section: Discussionmentioning

confidence: 92%

Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population

Kang

Zhu

et al. 2020

Iran J Pediatr

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Objectives:The aim of this study was to investigate the association between 2 single-nucleotide polymorphisms (SNP) of HLA-B and autism spectrum disorder (ASD). Methods: We enrolled 84 ASD and 182 healthy children in case-control study, and 67 family trios in family-based study. Two tag SNPs (rs1058026, rs2770) in gene HLA-B were selected to determine the association with ASD. Chi-square test was used in case-control study, haplotype relative risk test (HRR) and transmission disequilibrium test (TDT) analysis were performed in family-based study. Results: SNP rs1058026 was found significantly associated with ASD in family-based study (P = 0.016 for HRR; P = 0.020 for TDT), but not in case-control study. Conversely, SNP rs2770 did not show association with ASD in both studies. Conclusions:The association observed from this study indicates that gene HLA-B might play a role in ASD in Chinese population.Informed Consent: Each subject or their guardians (for children) signed a written informed consent regarding the use of their samples and basic information when they were hospitalized.

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DNA typing of HLA-A, -C, -B, AND -DRB1 in the children with autism in the Republic of Macedonia

Cited by 9 publications

References 33 publications

Association of HLA alleles with autism

Association of HLA alleles with autism

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population

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