Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population

Abstract

Objectives:The aim of this study was to investigate the association between 2 single-nucleotide polymorphisms (SNP) of HLA-B and autism spectrum disorder (ASD). Methods: We enrolled 84 ASD and 182 healthy children in case-control study, and 67 family trios in family-based study. Two tag SNPs (rs1058026, rs2770) in gene HLA-B were selected to determine the association with ASD. Chi-square test was used in case-control study, haplotype relative risk test (HRR) and transmission disequilibrium test (TDT) analysis were performed in family-based study. Results: SNP rs1058026 was found significantly associated with ASD in family-based study (P = 0.016 for HRR; P = 0.020 for TDT), but not in case-control study. Conversely, SNP rs2770 did not show association with ASD in both studies. Conclusions:The association observed from this study indicates that gene HLA-B might play a role in ASD in Chinese population.Informed Consent: Each subject or their guardians (for children) signed a written informed consent regarding the use of their samples and basic information when they were hospitalized.