DNA targeted platinum complexes: synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1-carboxamides

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

“…These results suggested a cytotoxic effect of these molecules initially by inhibiting DNA synthesis, which will induce a decrease of protein synthesis resulting in diminished cell survival. This pattern corresponds to the effects described for some platinum or other ruthenium derivatives known to bind to DNA [27][28][29][30][31][32]. Photodynamic studies revealed that the nature of the pyridylporphyrin isomer (3-pyridyl or 4-pyridyl) was more important than the degree of substitution of the tetrapyrrole ring.…”

How to modify 7-azaindole to form cytotoxic Pt(II) complexes: Highly in vitro anticancer effective cisplatin derivatives involving halogeno-substituted 7-azaindole

“…we also employed in the present work a method which consists in RNA synthesis by T7 RNA polymerase in vitro. This method was used in the same way as in several previous studies of the sequence specificity of various DNA-damaging agents including platinum drugs [21,[32][33][34]. T7 RNA polymerase was chosen to initiate these investigations because it is well characterized, its promoter is clearly defined, and the purified enzyme is commercially available.…”

Cellular accumulation and DNA platination of two new platinum(II) anticancer compounds based on anthracene derivatives as carrier ligands

“…The DNA-repair mechanisms have been found to be responsible for the cross-resistance with cisplatin in several cases, therefore, new platinum compounds with a totally different structure than those of cisplatin and analogues, have been developed. Platinum(II) compounds appended to an intercalator by a linker have been proposed and studied regarding interaction with DNA [39][40][41][42]. It has been shown that the presence of an intercalating chromophore enhances DNA binding [39,43].…”

“…Platinum(II) compounds appended to an intercalator by a linker have been proposed and studied regarding interaction with DNA [39][40][41][42]. It has been shown that the presence of an intercalating chromophore enhances DNA binding [39,43]. In addition, a longer linker chain between a platinum ion and the intercalator allows simultaneous platination and intercalation.…”