DNA Synthesis in Cartilage Cells Is Stimulated by Oscillating Electric Fields

Rodan, Gideon A.; Bourret, Lizabeth A.; Norton, Louis A.

doi:10.1126/science.625660

Cited by 223 publications

(67 citation statements)

References 39 publications

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“…Satake et al 23 found that calcium concentration in human periodontal ligament fibroblast cells was increased in the presence of PEMF. At the cellular level, Rodan et al 24 observed that cyclic nucleotides and calcium vehicles carry extracellular messages across the cell membrane. Interactions with diffusible ions, such as Ca2 + and K + , may convey an electric signal for DNA synthesis and cell division.…”

Section: Discussionmentioning

confidence: 99%

Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study

Darendeliler

Zea

Shen

et al. 2007

Australian Dental Journal

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Background: This study was designed to determine whether or not high-frequency and low-magnitude vibration affects orthodontic tooth movement caused by magnetic or/and mechanical forces. Methods: Forty-four 7-week-old Wistar rats were randomly divided into four groups, with each group further divided into experimental and control subgroups. Neodymium-Iron-Boron (Nd-Fe-B) magnets and Sentalloy closed coil springs were placed between maxillary or mandibular first molars and incisors to activate tooth movement. The animals of experimental subgroups were exposed to the vibration induced by pulsed electromagnetic fields (PEMF) whilst the control subgroups were under normal atmosphere. The experiment lasted for 14 days and all of the animals were sacrificed for examination. The changes in the space between the molar and incisor were measured to indicate the amount of tooth movement. Results: The coil springs, either with sham or active magnets, move molar much more than magnets alone, regardless of absence or presence of PEMF (p<0.001). Under PEMF, the coil spring moved significantly more amount of tooth movement than that of coil-magnet combination (p<0.01), as did the magnets compared to sham magnets (p<0.019). Under a non-PEMF scenario, there was no significant difference in tooth movement between coil spring and coil-magnets combination, nor was there difference between magnets and sham magnets. Conclusions: It is suggested that the PEMF-induced vibration may enhance the effect of mechanical and magnetic forces on tooth movement. S C I E N T I F I C A RT I C L EAbbreviations and acronyms: ME = method analysis; Nd-Fe-B = Neodymium-Iron-Boron; PEMF = pulsed electromagnetic field.

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Section: Discussionmentioning

confidence: 99%

Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study

Darendeliler

Zea

Shen

et al. 2007

Australian Dental Journal

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“…Rodan (1978) noted an enhancement of DNA synthesis in stimulated chick epiphyseal chondrocytes, but not in other non skeletal tissues. Norton ( 1979) stimulating embryonic rat calvaria cells and adding 3H-thymidine, also observed an increase in DNA synthesis in the area facing the cathode.…”

Section: Infroductionmentioning

confidence: 91%

Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice

Hinsenkamp¹,

Rooze²

1982

Acta Orthopaedica Scandinavica

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“…What can induce such metaplasia is completely unknown, even if it could be logically suspected that they are a consequence of physical stress, ischemia or other unknown factors [66]. For example, the synthesis of the DNA of the cartilaginous cells is stimulated by oscillating electric fields [77], but it can be supposed that such an effect exists in the fibrous body or near to it [66]. Cartilaginous meta-hyperplasia of the central fibrous body has already been described in cases of cardiac sudden death [1,66,67].…”

Section: Cartilaginous Meta-hyperplasia Of the Central Fibrous Bodymentioning

confidence: 99%

Crib death: further support for the concept of fatal cardiac electrical instability as the final common pathway

Ottaviani

Matturri

Rossi

et al. 2003

International Journal of Cardiology

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This work intends to be a review of the current status of knowledge on the cardiac conduction system in the crib death as well as remaining challenges, including reflections upon authors' personal works as well as many studies by others. The cardiac conduction system findings of resorptive degeneration, His bundle dispersion, Mahaim fibers, cartilaginous meta-hyperplasia, persistent fetal dispersion, left sided His bundle, hemorrhage of the atrio-ventricular junction, septation of the bifurcation, atrio-ventricular node dispersion, sinus node hypoplasia, Zahn node, His bundle hypoplasia, atrio-ventricular node and His bundle dualism are hereby discussed by the authors. The cardiac hypotheses postulating that crib death could be due to lethal cardiac arrhythmias or heart block were considered of great interest in the 1970s. After a general abandon of the conduction studies in crib death, the cardiac concept of crib death is gathering a renewed interest, as well as the occurrence of infantile junctional tachycardia. Both the morphological and functional derangement underlying crib death remain poorly understood, assuring that it remains to be a major medical and social problem. Despite the non-specificity of most of the cardiac conduction findings in crib death, we believe that they, in association with altered neurovegetative stimuli, could underlie potentially malignant arrhythmias, providing a morphologic support for the cardiac concept of crib death. D

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DNA Synthesis in Cartilage Cells Is Stimulated by Oscillating Electric Fields

Cited by 223 publications

References 39 publications

Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study

Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study

Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice

Crib death: further support for the concept of fatal cardiac electrical instability as the final common pathway

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