DNA Repair in Plants

Kimura, Seisuke; Sakaguchi, Kengo

doi:10.1021/cr040482n

Cited by 150 publications

(88 citation statements)

References 185 publications

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“…Thus, plants have not only developed mechanisms that filter or absorb UV-B to protect them against DNA damage (Mazza et al, 2000;Bieza and Lois, 2001) but also have different DNA repair systems to remove or tolerate DNA lesions (Hays, 2002;Bray and West, 2005;Kimura and Sakaguchi, 2006).…”

mentioning

confidence: 99%

ANTI-SILENCING FUNCTION1 Proteins Are Involved in Ultraviolet-Induced DNA Damage Repair and Are Cell Cycle Regulated by E2F Transcription Factors in Arabidopsis

et al. 2013

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ANTI-SILENCING FUNCTION1 (ASF1) is a key histone H3/H4 chaperone that participates in a variety of DNA-and chromatin-related processes, including DNA repair, where chromatin assembly and disassembly are of primary relevance. Information concerning the role of ASF1 proteins in the post-ultraviolet (UV) response in higher plants is currently limited. In Arabidopsis (Arabidopsis thaliana), an initial analysis of in vivo localization of ASF1A and ASF1B indicates that both proteins are mainly expressed in proliferative tissues. In silico promoter analysis identified ASF1A and ASF1B as potential targets of Elongation Factor2 (E2F) transcription factors. These observations were experimentally validated, both in vitro, by electrophoretic mobility shift assays, and in vivo, by chromatin immunoprecipitation assays and expression analysis using transgenic plants with altered levels of different E2F transcription factors. These data suggest that ASF1A and ASF1B are regulated during cell cycle progression through E2F transcription factors. In addition, we found that ASF1A and ASF1B are associated with the UV-B-induced DNA damage response in Arabidopsis. Transcript levels of ASF1A and ASF1B were increased following UV-B treatment. Consistent with a potential role in UV-B response, RNA interference-silenced plants of both genes showed increased sensitivity to UV-B compared with wild-type plants. Finally, by coimmunoprecipitation analysis, we found that ASF1 physically interacts with amino-terminal acetylated histones H3 and H4 and with acetyltransferases of the Histone Acetyl Transferase subfamily, which are known to be involved in cell cycle control and DNA repair, among other functions. Together, we provide evidence that ASF1A and ASF1B are regulated by cell cycle progression and are involved in DNA repair after UV-B irradiation.

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confidence: 99%

ANTI-SILENCING FUNCTION1 Proteins Are Involved in Ultraviolet-Induced DNA Damage Repair and Are Cell Cycle Regulated by E2F Transcription Factors in Arabidopsis

et al. 2013

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“…Furthermore, the Arabidopsis homologs of the subunit of DnA polymerase z (AtREV7) and REV1 were isolated and indicated to be involved in TLS (66). TLS DNA polymerase gene homologs were also predicted to be present in the rice genome (32). these observations suggest that higher plants possess the TLS mechanism responsible for the UV-defense mechanism.…”

Section: Dark Repairmentioning

confidence: 93%

“…The damaged bases are removed by BeR glycosylases, which cleave the glycosylic bound between the specific damaged base and the deoxyribose, with subsequent incision by AP-endonuclease (aprinic/apyrimidic endonuclease) at the resulting abasic site, followed by DnA synthesis and ligation (32). Bioinformatic identification of plant homologs of BER proteins (BER glycosylases and AP-endonuclease) in Arabidopsis (http:// www.ag.arizona.edu/dnametab/) and rice (32) suggested that molecular mechanism of BeR in plants is conserved and similar to that in yeast and humans. in higher plants, neR and BeR are active in proliferating cell, unlike the photorepair (33).…”

Section: Dark Repairmentioning

confidence: 99%

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Ultraviolet-Defense Mechanisms in Higher Plants

Ueda

Nakamura

2011

Biotechnology & Biotechnological Equipment

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“…This interaction ultimately results in degradation of CSA, CSB and possibly also RP2 (Groisman et al, 2006). Most of the proteins that play a role in GGR or TCR can be found in animals and plants, while only a few members, like XPA and TF2H3, a subunit of TFIIH, appear to be absent in plants ( Kimura and Sakaguchi, 2006). It is currently open whether plants encode for functional analogs of XPA and TF23H that would perform tasks similar to these proteins.…”

Section: Nucleotide Excision Repairmentioning

confidence: 99%