DNA repair genes hOGG1, XRCC1 and ERCC2 polymorphisms and their molecular mapping in breast cancer patients from India

Rajagopal, Taruna; Seshachalam, Arun; Rathnam, Krishnakumar; Arunachalam, J.; Viswanathan, Swarna; Talluri, Srikanth; Dunna, Nageswara Rao

doi:10.1007/s11033-020-05577-2

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Our data showed that silencing DCTPP1 up-regulates γ-H2AX expression. XRCC1 is reported to be activated via DNA damage, initiating cellular signaling cascades of great importance ( 33 , 34 ). Multiple studies suggest that hepatocarcinogenesis is triggered by aggregated lesions, including chromosomal aberrations and DNA damage as a result of impaired DNA damage response and dysregulated DNA damage repair ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway

et al. 2021

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Breast cancer (BRCA) is one of the most deadly cancers worldwide, with poor survival rates that could be due to its high proliferation. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is implicated in numerous diseases, including cancers. However, its role in BRCA is unclear. In this study, we used bioinformatic analyses of the ONCOMINE, UALCAN, and GEPIA databases to determine the expression pattern of DCTPP1 in BRCA. We found that elevated DCTPP1 levels correlate with poor BRCA prognosis. DCTPP1 silencing inhibited BRCA cell proliferation and induced apoptosis in vitro, as well as in vivo. Our data show that this tumorigenic effect depends on DNA repair signaling. Moreover, we found that DCTPP1 is directly modulated by miR-378a-3p, whose downregulation is linked to BRCA progression. Our results showed down-regulation of miR-378a-3p in BRCA. Upregulation of miR-378a-3p, on the other hand, can inhibit BRCA cell growth and proliferation. This study shows that reduced miR-378a-3p level enhances DCTPP1 expression in BRCA, which promotes proliferation by activating DNA repair signaling in BRCA.

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Section: Discussionmentioning

confidence: 99%

DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway

et al. 2021

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“…On the contrary, other studies reported no evidence of association between Portuguese (Costa et al, 2007 ), Brazilian (Dufloth et al, 2005 ), Chinese (Zhao & Ying, 2016 ), and Moroccan populations (Hardi et al, 2018 ). In the same vein, a Case/Control study (464 cases and 450 controls) conducted by Rajagopal et al ( 2020 ) on the Indian population showed no association between the ERCC2rs13181 (Lys751Gln) polymorphism and breast cancer risk. Furthermore, according to the study, the AA genotype conferred a significant protective effect against the development of triple‐negative tumors (OR = 0.49, 95% IC (0.26–0.92), p = .026) (Rajagopal et al, 2020 ).…”

Section: Discussionmentioning

confidence: 92%

“…In the same vein, a Case/ Control study (464 cases and 450 controls) conducted by Rajagopal et al (2020) on the Indian population showed no association between the ERCC2rs13181 (Lys751Gln) polymorphism and breast cancer risk. Furthermore, according to the study, the AA genotype conferred a significant protective effect against the development of triple-negative tumors (OR = 0.49, 95% IC (0.26-0.92), p = .026) (Rajagopal et al, 2020). All of these studies suggest that ethnicity, sample characteristics, and environmental factors that interact with this variant should be considered in the analysis of outcomes.…”

Section: Ercc1rs3212986 Ercc2rs1799793 Ercc2rs13181 Polymorphisms And...mentioning

confidence: 96%

Involvement of ERCC1 (rs3212986) and ERCC2 (rs1799793, rs13181) polymorphisms of DNA repair genes in breast cancer occurrence in Burkina Faso

Adico¹,

Zoure

Sombié³

et al. 2023

Molec Gen & Gen Med

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Background Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was to evaluate the involvement of two DNA repair genes, ERCC1 ( rs3212986, GenBank NC_000073.9) and ERCC2 ( rs1799793, rs13181 , GenBank: NC_000019.10 ) in the occurrence of breast cancer in Burkina Faso. Methods This case–control study enrolled 128 participants including 64 patients and 64 healthy controls. Genotyping of polymorphisms were performed by real‐time PCR and PCR‐RFLP. Results The heterozygous AC genotype of the ERCC2rs13181 polymorphism was associated with the occurrence of breast cancer when the mutant allele is inherited under the dominant pattern (CC/AC vs AA; OR = 2.74, 95% IC (1.09–6.87); p = .028), but this association became insignificant after the Bonferroni correction ( p = .156). No association was observed between ERCC1 rs3212986 and ERCC2rs1799793 polymorphisms and breast cancer risk. Conclusion This study showed that the heterozygous genotype (CA) of the ERCC2rs13181 polymorphism may be associated with a risk of breast cancer.

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Impact of xenobiotic-metabolizing gene polymorphisms on breast cancer risk in South Indian women

Rajagopal

Seshachalam

Rathnam

et al. 2021

Breast Cancer Res Treat

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DNA repair genes hOGG1, XRCC1 and ERCC2 polymorphisms and their molecular mapping in breast cancer patients from India

Cited by 4 publications

References 34 publications

DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway

DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway

Involvement of ERCC1 (rs3212986) and ERCC2 (rs1799793, rs13181) polymorphisms of DNA repair genes in breast cancer occurrence in Burkina Faso

Impact of xenobiotic-metabolizing gene polymorphisms on breast cancer risk in South Indian women

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