Impact of xenobiotic-metabolizing gene polymorphisms on breast cancer risk in South Indian women

Rajagopal, Taruna; Seshachalam, Arun; Rathnam, Krishnakumar; Arunachalam, J.; Talluri, Srikanth; Venkatabalasubramanian, Sivaramakrishnan; Dunna, Nageswara Rao

doi:10.1007/s10549-020-06028-z

Cited by 5 publications

(1 citation statement)

References 66 publications

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“…Additionally, exploring this human genetic variation could go a long way in saving the vulnerable group, because some disease-susceptible alleles occur more frequently among people of certain geographic areas. Unfortunately, fewer studies have examined the connection between genetic polymorphisms in XME, DNA damage and cancer [36], especially in pesticide-exposed populations. Even with that, several inconsistencies in the reports often make valid conclusions very challenging.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms and Pesticide-Induced DNA Damage: A Review

Usman¹,

Priya²,

Pandit³

et al. 2021

TOBIOTJ

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The drastic increase in pesticide applications makes human exposure inevitable either through environment or occupation. Pesticide toxicity causes many adverse health effects through a number of pathways leading to DNA damage, mutations and cancers. Nevertheless, there is heterogeneity in the degree of toxicity among individuals due to the influence of genetic polymorphisms on xenobiotic metabolizing enzymes (XMEs) that modulate the biological process. Thus, study of the most common polymorphic genes coding for the enzymes involved in pesticide metabolism (such as cytochrome P450, Glutathione S-transferases, N-acetyltransferase and paraoxonase) may help determine individual’s susceptibility to pesticide toxicity. In this review, we give an overview of some recent developments in the field of genetic polymorphism and pesticide-related DNA damage, including probable biomarkers that may uncover genome susceptibility to pesticide toxicity. We have tried to create a connection between DNA polymorphism and cancer onslaught globally. It is envisaged that knowledge on this line would improve our understanding of facilitating the association between genotype and phenotype in cancer biology.

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Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms and Pesticide-Induced DNA Damage: A Review

Usman¹,

Priya²,

Pandit³

et al. 2021

TOBIOTJ

View full text Add to dashboard Cite

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Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population

et al. 2022

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Background: Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes (AhR, CYP1A1, GSTM1, and GSTT1) on cervical cancer development in Tunisian women. Methods:The AhR gene polymorphism was analyzed using the tetra-primer ARMS-PCR, whereas the CYP1A1 polymorphism genotypes were identified by PCR-RFLP. A multiplex ligation-dependent polymerase chain reaction approach was applied for the analysis of GSTM1 and GSTT1 polymorphisms. Results:The homozygous A/A genotype of the AhR gene (rs2066853) and the heterozygous T/C genotype of the CYP1A1 SNP (CYP1A1-MspI) appeared to be associated with an increased risk of cervical tumorigenesis (OR a = 2.81; OR a = 5.52, respectively). Furthermore, a significantly increased risk of cervical cancer was associated with the GSTT1 null genotype (OR a = 2.65). However, the null GSTM1 genotype showed any significant association with the risk of cervical cancer compared to the wild genotype (OR a = 1.18; p = 0.784). Considering the combined effect, we noted a significantly higher association with cancer risk for individuals with at least two high-risk genotypes of CYP1A1/GSTT1 (OR a = 4.2), individuals with at least two high-risk genotypes of CYP1A1/GSTT1/AhR (OR a = 11.3) and individuals with at least two high-risk genotypes of CYP1A1/GSTM1/GSTT1/AhR exploitation low-risk genotype as a reference. Conclusion:This study indicated that the single-gene contribution and the combined effect of xenobioticmetabolizing gene polymorphisms (AhR, CYP1A1-MspI, GSTM1, and GSTT1) may have a considerable association with increased cervical cancer risk.

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