DNA Repair Defect and <i>RAS</i> Mutation in Two Patients With <i>Schistosoma mansoni</i>–Associated Colorectal Cancer: Carcinogenesis Steps or Mere Coincidence?

Almeida, Gustavo Fernandes Godoy; Sarinho, Filipe Wanick; Lima, Paula Carvalho de Abreu e; Filho, Joao Bosco Oliveira; Moura, Márcio das Chagas; Ribeiro, Lais Neares Barbosa; Brito, Bruno Rolim de; Lira, Mariana Montenegro de Melo; Maior, Marcelo do Rego Maciel Souto; Domingues, Ana Lúcia Coutinho

doi:10.1200/jgo.2016.006254

Cited by 4 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various helminths have been proven to be a carcinogenic agent in human, such as the liver fluke Clonorchis sinensis and Opisthorchis viverini (causative agents of cholangiocarcinoma) (Feng and Cheng, 2017) and the blood fluke Schistosoma japonicum (well-known risk factor for liver carcinoma and colorectal cancer) (Takemura et al, 1998; Hamid, 2019), Schistosoma mansoni (suspected risk factor for colorectal cancer) (Almeida et al, 2017), and Schistosoma haematobium (which leads to bladder cancer) (Berry et al, 2017). On the other hand, accumulating evidence suggested that certain helminth infection could induce anticancer activities, such as the pork worm Trichinella spiralis , which can protect infected mice against tumor growth and metastasis (Kang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Employing Parasite Against Cancer: A Lesson From the Canine Tapeworm Echinococcus Granulocus

et al. 2019

View full text Add to dashboard Cite

Cystic echinococcosis (CE), a devastating zoonotic condition caused by the tapeworm Echinococcus granulosus, remain a significant public health problem worldwide. However, after a negative correlation between solid tumor and CE has been incidentally discovered, accumulating evidence have suggested that this parasite may induce anticancer effect through activating host immune response and secreting molecules with anticancer potential, which may provide some new understanding for immunotherapy. This article will review the evidence supporting the anticancer effect of E. granulosus and its underlying mechanisms and discuss the possible implications in immunotherapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Employing Parasite Against Cancer: A Lesson From the Canine Tapeworm Echinococcus Granulocus

et al. 2019

View full text Add to dashboard Cite

show abstract

“…There are only a few data available about the molecular mechanisms of intestinal schistosomiasis from S. mansoni infection analyzing the dysregulation of the malignant colon. A recent study described a DNA repair defect and a RAS mutation in two patients with S. mansoni-associated CRC [159]. The authors discussed whether these mutations might have been crucial for carcinogenesis or mere coincidence [159].…”

Section: Intestinal Schistosomiasismentioning

confidence: 99%

“…A recent study described a DNA repair defect and a RAS mutation in two patients with S. mansoni-associated CRC [159]. The authors discussed whether these mutations might have been crucial for carcinogenesis or mere coincidence [159]. Several studies indicated the involvement of p53 [46,48,160].…”

Section: Intestinal Schistosomiasismentioning

confidence: 99%

Does Schistosoma Mansoni Facilitate Carcinogenesis?

Bülow

Lichtenberger

Grevelding

et al. 2021

Cells

View full text Add to dashboard Cite

Schistosomiasis is one of the most prominent parasite-induced infectious diseases, causing tremendous medical and socioeconomic problems. Current studies have reported on the spread of endemic regions and the fear of development of resistance against praziquantel, the only effective drug available. Among the Schistosoma species, only S. haematobium is classified as a Group 1 carcinogen (definitely cancerogenic to humans), causing squamous cell carcinoma of the bladder, whereas infection with S. mansoni is included in Group 3 of carcinogenic hazards to humans by the International Agency for Research on Cancer (IARC), indicating insufficient evidence to determine its carcinogenicity. Nevertheless, although S. mansoni has not been discussed as an organic carcinogen, the multiplicity of case reports, together with recent data from animal models and cell culture experiments, suggests that this parasite can predispose patients to or promote hepatic and colorectal cancer. In this review, we discuss the current data, with a focus on new developments regarding the association of S. mansoni infection with human cancer and the recently discovered biomolecular mechanisms by which S. mansoni may predispose patients to cancer development and carcinogenesis.

show abstract

“…(8) Recently, our research group has reported two young patients with colorectal cancer and schistosomiasis in whom microsatellite instability and RAS mutation have been identified. (9) Whether Schistosoma induces carcinogenesis is not clear yet. Hanahan and Weinberg have proposed six hallmarks of cancer that they define as "distinctive and complementary capabilities that enable tumor growth and metastatic dissemination."…”

Section: Introductionmentioning

confidence: 99%

Análise proxy de internações por câncer colorretal e incidência de Schistosoma Mansoni

Almeida¹,

Freitas²,

Ribeiro³

et al. 2019

BJOncology

Self Cite

View full text Add to dashboard Cite

Schistosoma has been associated with colorectal cancer. We compared the number of colorectal cancer admissions between those cities in the state of Pernambuco with and without schistosomiasis. We abstracted data from Datasus and analyzed the number of admissions due to CRC in those cities with (CRC/Schistosoma) and without schistosomiasis (CRC-alone) in the State of Pernambuco and compared these numbers using odds ratio and relative risk at a significance level of 5%. This was preceded by an F test to reject the null hypothesis that the number of cities in each group was the same. The mean number of admissions due to CRC in CRC-Schistosoma cities was 94.55, with a variability of 366%, while in CRC-alone cities the mean was 11.06, with a variability of 88%. A test at a significance level of 5% rejected the hypothesis that these variances were the same (p-value, 0.0000). A subsequent test also rejected the null hypothesis that the mean of admissions was the same (two-sided p-value 0.0167). The state of Pernambuco encompasses 184 cities of which 103 registered schistosomiases (102 with colorectal cancer and 1 without). We compared the number of admissions due to CRC and/or due to schistosomiasis with admissions due to other diseases to measure the odds ratio for colorectal cancer due to schistosomiasis exposure. This comparison resulted in an OR of 2.657 (CI 95% 2,478-2,849) for CRC due to exposure to schistosomiasis. We found a statistically significant correlation between colorectal cancer admissions and schistosomiasis in the state of Pernambuco. Pharmacoeconomic studies might proof if investment to prevent nematode infestation would translate into cost spare with less admissions due to cancer and cancer treatments.

show abstract

DNA Repair Defect and RAS Mutation in Two Patients With Schistosoma mansoni–Associated Colorectal Cancer: Carcinogenesis Steps or Mere Coincidence?

Cited by 4 publications

References 14 publications

Employing Parasite Against Cancer: A Lesson From the Canine Tapeworm Echinococcus Granulocus

Employing Parasite Against Cancer: A Lesson From the Canine Tapeworm Echinococcus Granulocus

Does Schistosoma Mansoni Facilitate Carcinogenesis?

Análise proxy de internações por câncer colorretal e incidência de Schistosoma Mansoni

Contact Info

Product

Resources

About