DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients

Sterpone, Silvia; Cornetta, Tommaso; Padua, Luca; Mastellone, Valeria; Giammarino, Daniela; Testa, Antonella; Tirindelli, Donatella; Cozzi, Renata; Donato, Vittorio

doi:10.1016/j.mrfmmm.2009.11.009

Cited by 42 publications

(25 citation statements)

References 25 publications

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“…Results showed that XRCC1-399 SNP significantly increased susceptibility to breast cancer, confirming our previous data obtained on a smaller sample of 43 BC patients [1,17] and suggests a dominant inheritance model for the XRCC1-399 variant allele.…”

Section: Discussionsupporting

confidence: 89%

“…We previously reported a strong significant association between breast cancer occurrence and the presence of the XRCC1 variant allele (399-Gln) in a cohort of Italian patients [17]. In the present study we examined a larger number of BC patients with the aim to assess whether SNPs and haplotypes in XRCC1 gene were associated with an increased risk of both developing the disease and adverse reactions after radiotherapy.…”

Section: Discussionmentioning

confidence: 92%

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Polymorphisms in X-Ray Repair Cross-Complementing Group 1 Gene: Haplotypes, Breast Cancer Risk and Individual Radiosensitivity

Patrono¹,

Sterpone²,

Testa³

et al. 2015

MEDJ

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Abstract:The aim of this paper is to analyse the role exerted by X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and haplotypes in increasing breast cancer risk and in modulating radiotherapy-induced adverse reactions. An Italian cohort of breast cancer patients and a matching group of healthy controls were genotyped for XRCC1-77T>C, Arg194Trp and Arg399Gln polymorphisms. Our data indicated that polymorphisms at codon 399 and at -77 position of the 5'-untraslated region both contribute to cancer risk. We also showed that the haplotype H3, containing the wild-type allele at codon 194 and the variant alleles at codon 399 and at -77 position is significantly associated with an increased risk of breast cancer. We found no statistical association between XRCC1 SNPs and individual radiosensitivity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Polymorphisms in X-Ray Repair Cross-Complementing Group 1 Gene: Haplotypes, Breast Cancer Risk and Individual Radiosensitivity

Patrono¹,

Sterpone²,

Testa³

et al. 2015

MEDJ

Self Cite

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“…Thirty-one studies for Arg194Trp (14,381 cases and 15.036 controls), 10 for Arg280His (7,716 cases and 7,370 controls) and 52 for Arg399Gln (31,036cases and 35,994 controls) included in this meta-analysis. several studies (Duell et al, 2001;Romanowicz-Makowska et al, 2007;Sterpone et al, 2010a;Smith et al, 2011;Lee et al, 2014) were excluded because of common studied population with some others (Pachkowski et al, 2006a;Smith et al, 2008;Sobczuk et al, 2009b;Sterpone et al, 2010c). One publication (Consortium, 2006) carried out analysis of nine different studies.…”

Section: Resultsmentioning

confidence: 99%

XRCC1 Gene Polymorphisms and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Moghaddam

Nazarzadeh²,

Moghaddam³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Of these, 10 articles were excluded (four were reviews, four did not report usable data, and two were not case-control studies). Finally, a total of 11 eligible studies involving 6,804 cases and 6,725 controls were included in the pooled analyses [12][13][14][15][16][17][18][19][20][21][22]. The characteristics of selected studies are summarized in Table 1.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies

Wang

Zhang

et al. 2010

Breast Cancer Res Treat

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The functional Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Eleven published case-control studies, including 6,804 breast cancer cases and 6,725 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Overall, no significant associations between the hOGG1 Ser326Cys polymorphism and breast cancer risk were found for Cys/Cys versus Ser/Ser (OR = 1.07, 95% CI: 0.94-1.20), Ser/Cys versus Ser/Ser (OR = 0.99, 95% CI: 0.91-1.07), Cys/Cys + Ser/Cys versus Ser/Ser (OR = 1.00, 95% CI = 0.93-1.08), and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.07, 95% CI: 0.97-1.18). In the stratified analysis by ethnicity, source of controls, and menopausal status, significant associations were still not observed in all genetic models. Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism is not associated with breast cancer risk.

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DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients

Cited by 42 publications

References 25 publications

Polymorphisms in X-Ray Repair Cross-Complementing Group 1 Gene: Haplotypes, Breast Cancer Risk and Individual Radiosensitivity

Polymorphisms in X-Ray Repair Cross-Complementing Group 1 Gene: Haplotypes, Breast Cancer Risk and Individual Radiosensitivity

XRCC1 Gene Polymorphisms and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies

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