Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies

Gu, Dongying; Wang, Meilin; Zhang, Zhengdong; Chen, Jinfei

doi:10.1007/s10549-009-0723-4

Cited by 28 publications

(22 citation statements)

References 23 publications

(35 reference statements)

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“…These results were discussed by Ding et al [28] , who combined all of the studies on European populations and performed a new meta-analysis, which indicated a lack of association between the OGG1 326Cys allele and BC risk for this ethnicity. This result was confirmed by the metaanalysis performed by Gu et al [29] , who identified 11 casecontrol studies published from 2003 to 2009; however, they did not observe any significant association between Ser326Cys SNP and BC risk, even in the analyses stratified by ethnicity, source of controls and menopausal status. An additional case-control study not included in the aforementioned meta-analysis also showed a lack of association between the OGG1 Ser326Cys variant and BC susceptibility [30] .…”

supporting

confidence: 54%

“…Ser326Cys 4 There was a lack of association between this SNP and BC risk in a European population Gu et al [29] …”

Section: Ogg1mentioning

confidence: 99%

“…To clarify the findings, several meta-analyses have been performed (Table 2) [27][28][29] . Yuan et al [27] collected data published from 2003 to 2008 and evaluated the association between the OGG1 Ser326Cys SNP and BC onset according to menopausal status and ethnicity by performing a stratified analysis.…”

mentioning

confidence: 99%

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Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

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et al. 2014

WJCO

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Breast cancer (BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common treatment for BC includes breast-conserving surgery followed by a standard radiotherapy (RT) regimen. However, radiation hypersensitivity and the occurrence of RT-induced toxicity in normal tissue may affect patients' treatment. The role of DNA repair in cancer has been extensively investigated, and an impaired DNA damage response may increase the risk of BC and individual radiosensitivity. Single nucleotide polymorphisms (SNPs) in DNA repair genes may alter protein function and modulate DNA repair efficiency, influencing the development of various cancers, including BC. SNPs in DNA repair genes have also been studied as potential predictive factors for the risk of RT-induced side effects. Here, we review the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on X-ray repair cross complementing group 1 (XRCC1 ), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly (ADP-ribose) polymerase-1, which encode three important BER enzymes that interact with XRCC1. Although no association between SNPs and radiation toxicity has been validated thus far, we also report published studies on XRCC1 SNPs and variants in other BER genes and RT-induced side effects in BC patients, emphasising that large well-designed studies are needed to determine the genetic components of individual radiosensitivity.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Breast cancer; Polymorphisms; Base excision repair; Susceptibility; Radiosensitivity Core tip: Single nucleotide polymorphisms (SNPs) in DNA repair genes may modulate DNA repair efficiency, influencing the development of various cancers, including breast cancer (BC). SNPs in DNA repair genes have also been studied as predictors for the risk of radiotherapy-induced side effects. We reviewed the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on X-ray repair cross complementing group 1, 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly (ADP-ribose) polymerase-1, which encode four important BER proteins. We also report published studies on SNPs in BER genes and individual radiosensitivity in BC patients.

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supporting

confidence: 54%

“…Ser326Cys 4 There was a lack of association between this SNP and BC risk in a European population Gu et al [29] …”

Section: Ogg1mentioning

confidence: 99%

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Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

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et al. 2014

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“…However, no significant association between the OGG1 326Cys allele and breast cancer was found among Asian women (Yuan et al, 2010). Additionally, another meta-analysis of OGG1 Ser326Cys, which included data from 11 studies, also failed to observe an association between OGG1 Ser326Cys and breast cancer risk in the in European or Asian subjects or in an analysis stratified by ethnicity, source of control subjects, and menopausal status (Gu et al, 2010). We found that OGG1 Ser326Cys conferred a significant protective effect against breast cancer among women having a low BMI (< 24 kg/m 2 ) and the OGG1 Ser/Cys genotype (P = 0.027) or OGG1 Cys/Cys genotype (P = 0.005).…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population

Luo¹,

Li²,

Qu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Altered DNA repair capacity can result in increased susceptibility to cancer. The base excision repair (BER) pathway effectively removes DNA damage caused by ionizing radiation and reactive oxidative species (ROS). In the current study, we analyzed the possible relation of polymorphisms in BER genes, including 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), and X-ray repair cross-complementing group 1 protein (XRCC1), with breast cancer risk in Chinese Han women. This case-control study examined 194 patients with breast cancer and 245 cancer-free hospitalized control subjects. Single nucleotide polymorphisms (SNPs) of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), and APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their association with breast cancer risk using multivariate logistic regression models. We found that XRCC1 Arg399Gln was significantly associated with an increased risk of breast cancer. Similarly, the XRCC1 Gln allele was significantly associated with an elevated risk in postmenopausal women and women with a high BMI (≥ 24 kg/m 2 ). The OGG1 Cys allele provided a significant protective effect against developing cancer in women with a low BMI (< 24 kg/m 2 ). When analyzing the combined effects of these alleles on the risk of breast cancer, we found that individuals with ≥ 2 adverse genotypes (XRCC1 399Gln, APE1 148Asp, and OGG1 326Ser) were at a 2.18-fold increased risk of breast cancer (P = 0.027). In conclusion, our data indicate that Chinese women with the 399Gln allele of XRCC1 have an increased risk of breast cancer, and the combined effects of polymorphisms of BER genes may contribute to tumorigenesis.

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“…We have also read with great interest the recent metaanalysis by Gu et al [6], the study of Gu et al [6] had eleven case-control studies, and the results suggest that no significant associations between the hOGG1 Ser326Cys polymorphism and breast cancer risks were observed in all genetic model. And in the stratified analysis by ethnicity, no significant results were observed in European population (Cys/Cys vs. Ser/Ser: OR = 0.93, 95% CI = 0.77-1.13; dominant model: OR = 0.96, 95% CI = 0.88-1.05), which is consistent with our findings.…”

Section: To the Editormentioning

confidence: 96%

Lack of association between hOGG1 Ser326Cys polymorphism and breast cancer susceptibility in European population

Ding

Zhang

2011

Breast Cancer Res Treat

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Recently, we read with great interest the article ''The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis'' published online in August 2010 issue of ''Breast Cancer Research and Treatment'' [1]. The study of Yuan et al. performed a meta-analysis to make an estimation of the association between the DNA repair gene hOGG1 Ser326Cys polymorphism (rs1052133) and breast cancer susceptibility, and the results showed that individuals who carrying the hOGG1 326Cys allele did not have significantly increased risk of breast cancer compared with those carrying the 326Ser allele. However, in the stratified analysis by ethnicity, the meta-analysis showed the association between hOGG1 326Cys allele in the additive model, and breast cancer was significant in European subject (OR = 0.71, 95% CI = 0.51-0.98), and dominant genetic model (OR = 0.44, 95%CI = 0.25-0.77), and the 326Cys allele plays a protective effect on the carcinogenesis of breast cancer among them.Nevertheless, there are some comments we would like to raise. Using the same search strategy and end-of-search

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Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies

Cited by 28 publications

References 23 publications

Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population

Lack of association between hOGG1 Ser326Cys polymorphism and breast cancer susceptibility in European population

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