DNA nanostructures as templates for biomineralization

Athanasiadou, Dimitra; Carneiro, Karina M. M.

doi:10.1038/s41570-020-00242-5

Cited by 48 publications

(42 citation statements)

References 211 publications

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“…As such, DNA nanostructures could also serve as scaffolds for the direct growth of biominerals in vivo . 96 For this, however, biomineralization procedures would have to be adapted to be nontoxic to the patient, and DNA nanostructures would need to be grown to a large enough size. Although this may not be straightforward, with the power of a hierarchical assembly and milligram-scale production of DNA origami structures, 97 it may well be possible in the future.…”

Section: Discussionmentioning

confidence: 99%

“…However, the complete shape control over DNA nanostructures makes them extremely attractive templates for biomineralization. 34 Pioneering work in the biomimetic mineralization of biomolecules was carried out especially by the research groups of Shinkai, 35 Mann, 36 Brinker, 37 and Che. 38 However, adapting such processes designed for ssDNA or double-stranded DNA (dsDNA) molecules to DNA nanostructures—and DNA origami in particular—is far from trivial due to charges and buffer stability requirements.…”

Section: Mineralization—synthesis and Achieved Propertiesmentioning

confidence: 99%

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Engineering Inorganic Materials with DNA Nanostructures

Heuer‐Jungemann

Linko

2021

ACS Cent. Sci.

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Nucleic acid nanotechnology lays a foundation for the user-friendly design and synthesis of DNA frameworks of any desirable shape with extreme accuracy and addressability. Undoubtedly, such features make these structures ideal modules for positioning and organizing molecules and molecular components into complex assemblies. One of the emerging concepts in the field is to create inorganic and hybrid materials through programmable DNA templates. Here, we discuss the challenges and perspectives of such DNA nanostructure-driven materials science engineering and provide insights into the subject by introducing various DNA-based fabrication techniques including metallization, mineralization, lithography, casting, and hierarchical self-assembly of metal nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Section: Mineralization—synthesis and Achieved Propertiesmentioning

confidence: 99%

Engineering Inorganic Materials with DNA Nanostructures

Heuer‐Jungemann

Linko

2021

ACS Cent. Sci.

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“…First, the highly hydrated amorphous phase possesses liquid-like fluidity and moldability, which are believed to be the foundations of structuring sophisticated minerals, especially in extremely tiny compartments. 47 Second, compared with ion solutions, ACP is a concentrated phase of calcium and phosphate, which is more efficient in mineralization and more convenient in delivery. 43 Third, ACP is more soluble than HAP, thus having more flexible and controllable properties in reorganization and fusion.…”

Section: Bone Repairmentioning

confidence: 99%

Advances in biomineralization-inspired materials for hard tissue repair

Tang

Dong

et al. 2021

Int J Oral Sci

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Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties, including the bones and teeth in vertebrates. The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues. In particular, the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization. Here, we review recent advances in biomineralization-inspired materials developed for hard tissue repair. Biomineralization-inspired materials are categorized into different types based on their specific applications, which include bone repair, dentin remineralization, and enamel remineralization. Finally, the advantages and limitations of these materials are summarized, and several perspectives on future directions are discussed.

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“…[102] Given the high negative polarity and scaffold-like architecture of DNA nanostructures, they have been extensively studied for their ability to promote biomineralization. [103] In a recent study, DNA nanostructures conjugated with polyaspartic acid were purposed as a scaffold to enhance mineralization. Here, DNA nanotubes made of a single DNA strand were utilized due to their simple configuration and self-assembly.…”

Section: Impact Of Structural Dna Nanotechnology In Bone Tissue Engineeringmentioning

confidence: 99%

Advancements in nucleic acids‐based techniques for bone regeneration

Sidharthan

Abhinandan

Balagangadharan

et al. 2021

Biotechnology Journal

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The dynamic biology of bone involving an enormous magnitude of cellular interactions and signaling transduction provides ample biomolecular targets, which can be enhanced or repressed to mediate a rapid regeneration of the impaired bone tissue. The delivery of nucleic acids such as DNA and RNA can enhance the expression of osteogenic proteins. Members of the RNA interference pathway such as miRNA and siRNA can repress negative osteoblast differentiation regulators. Advances in nanomaterials have provided researchers with a plethora of delivery modules that can ensure proper transfection. Combining the nucleic acid carrying vectors with bone scaffolds has met with tremendous success in accomplishing bone formation. Recent years have witnessed the advent of CRISPR and DNA nanostructures in regenerative medicine. This review focuses on the delivery of nucleic acids and touches upon the prospect of CRISPR and DNA nanostructures for bone tissue engineering, emphasizing their potential in treating bone defects.

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DNA nanostructures as templates for biomineralization

Cited by 48 publications

References 211 publications

Engineering Inorganic Materials with DNA Nanostructures

Engineering Inorganic Materials with DNA Nanostructures

Advances in biomineralization-inspired materials for hard tissue repair

Advancements in nucleic acids‐based techniques for bone regeneration

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