DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice

Chronic diseases account for over 60% of all deaths worldwide according to the World Health Organization reports. Majority of cases are triggered by environmental exposures that lead to aberrant changes in the epigenome, specifically, the DNA methylation patterns. These changes result in altered expression of gene networks and activity of signalling pathways. Dietary antioxidants, including catechins, flavonoids, anthocyanins, stilbenes and carotenoids, demonstrate benefits in the prevention and/or support of therapy in chronic diseases. This review provides a comprehensive discussion of potential epigenetic mechanisms of antioxidant compounds in reversing altered patterns of DNA methylation in chronic disease. Antioxidants remodel the DNA methylation patterns through multiple mechanisms, including regulation of epigenetic enzymes and chromatin remodelling complexes. These effects can further contribute to antioxidant properties of the compounds. On the other hand, decrease in oxidative stress itself can impact DNA methylation delivering additional link between antioxidant mechanisms and epigenetic effects of the compounds. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…Curcumin treatment restored the high methylation profile of Tnf, which coincided with a decrease in Tnf expression (Guo et al, 2018).…”

Section: A Link Between Antioxidant Properties Of Curcumin and Curcmentioning

confidence: 84%

Dietary antioxidants remodel DNA methylation patterns in chronic disease

Beetch

Harandi-Zadeh

Shen

et al. 2019

British J Pharmacology

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“…A study by Irizarry etc show that most methylation alterations in colorectal cancer occur in 'CpG island shores', with hypermethylation enriched closer to the associated CpG islands [28]. Moreover, Guo etc demonstrate that epigenomic changes in DNA CpG methylation are closely associated with the local inflammatory response from colorectal cancer [29]. Here we identified 16 specifc expressed CpG methylation sites, which associated with 9 different genes (CCDC48, CSNK1A1L, GDNF, HYDIN, IRX5, LONRF2, NALCN, SLC16A12, TNXB).…”

Section: Discussionmentioning

confidence: 99%

A 16-CpG-based Prognostic Signature for Colorectal Cancer

Chen

Wang

Zhang

et al. 2020

Preprint

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Background: To develop a CpG-based prognostic prediction model to provide survival risk prediction for colorectal cancer. Differential methylation analysis was performed on 309 colorectal cancer and 38 adjacent cancer specimens from the Cancer Genome Atlas (TCGA). Results: 2113 hypermethylation sites as well as 723 hypomethylation sites were screened out and 16 related CpG methylation loci were further identified. The risk score was calculated based on the methylation sites identified and utilized as an independent prognostic variable for multivariate Cox regression prediction model, which was further optimized by the independent prognostic factors (including stage and risk score). Conclusion: This study has identified several potential prognostic biomarkers and established a CpG-based prognostic prediction model for colorectal cancer, which provides a valuable reference for future clinical research.

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“…Epigenetic modifications are highly associated with dietary factors [46]. In this regard, Yue Guo et al [47] studied DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-associated CRC in mice. Four-week-old male C57BL/6 wild-type mice received a chemical treatment of AOM and dextran sulphate sodium (DSS).…”

Section: In Vivo Studies: the Effect Of Curcumin On Colorectal Cancermentioning

confidence: 99%

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

Pricci

Girardi

Giorgio

et al. 2020

IJMS

151

100

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Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans.

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DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice

Cited by 102 publications

References 63 publications

Dietary antioxidants remodel DNA methylation patterns in chronic disease

Dietary antioxidants remodel DNA methylation patterns in chronic disease

A 16-CpG-based Prognostic Signature for Colorectal Cancer

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

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