2013
DOI: 10.1098/rstb.2011.0328
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DNA methylation dynamics during the mammalian life cycle

Abstract: DNA methylation is dynamically remodelled during the mammalian life cycle through distinct phases of reprogramming and de novo methylation. These events enable the acquisition of cellular potential followed by the maintenance of lineage-restricted cell identity, respectively, a process that defines the life cycle through successive generations. DNA methylation contributes to the epigenetic regulation of many key developmental processes including genomic imprinting, X-inactivation, genome stability and gene reg… Show more

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Cited by 268 publications
(179 citation statements)
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References 98 publications
(150 reference statements)
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“…Increasing evidence indicates that, similar to protein-coding genes, epigenetic mechanisms, such as DNA methylation and histone acetylation, may be associated with the regulation of miRNA expression (28). DNA methylation at the dinucleotide CpG is one of the most common epigenetic modifications in eukaryotic genomes and plays a significant role in various biological processes (29). The majority of human miRNA genes have been found to be associated with CpG islands (30).…”
Section: Discussionmentioning
confidence: 99%
“…Increasing evidence indicates that, similar to protein-coding genes, epigenetic mechanisms, such as DNA methylation and histone acetylation, may be associated with the regulation of miRNA expression (28). DNA methylation at the dinucleotide CpG is one of the most common epigenetic modifications in eukaryotic genomes and plays a significant role in various biological processes (29). The majority of human miRNA genes have been found to be associated with CpG islands (30).…”
Section: Discussionmentioning
confidence: 99%
“…[9][10][11][12] DNA methylation has been extensively analyzed from a genomic perspective in both normal and pathological tissues, [13][14][15] but the dynamics underlying the methylation and demethylation processes are still not well defined. Several models have addressed these 2 processes by considering the possible influence of the physical distance between CpG sites on these processes.…”
Section: Introductionmentioning
confidence: 99%
“…Genome-wide DNA demethylation is observed at two stages of embryonic development, in the fertilized zygote and during the specification of primordial germ cells (PGCs) (9,10). In PGCs, Tet1 and Tet2 contribute to DNA demethylation through a replication-dependent mechanism (9).…”
mentioning
confidence: 99%