DNA methylation and control of genome organization in Neurospora crassa

Selker, Eric U.; Cambareri, Edward B.; Garrett, Philip W.; Haack, Kenneth R.; Jensen, Bryan C.; Schabtach, Eric

doi:10.1016/0378-1119(88)90264-8

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…In vertebrate somatic cells, satellite DNA sequences are heavily methylated and are present in an inactive, condensed, late-replicating chromatin configuration and the same is true for one of the Xchromosomes in the cells of female mammals (see below). In Neurospora crassa and Ascobolus immersus amplified DNA also becomes heavily methylated and inactivated in the premeiotic phase (Bull & Wootton, 1984;Selker & Stevens, 1987;Selker et al, 1988;Goyon & Faugeron, 1989). This modification affects DNA undergoing duplication as well as transforming DNA introduced into the cells, and all copies of the duplicated DNA are inactivated.…”

Section: Chromatin Structurementioning

confidence: 99%

DNA methylation. The effect of minor bases on DNA-protein interactions

Adams

1990

Biochemical Journal

182

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DNA methylation is found almost ubiquitously in nature and the methyltransferases show evidence of a common evolutionary origin. It will be a fascinating study in protein evolution to follow the ways in which the structures of the various enzymes have developed. Although methylation may have a direct effect on DNA structure the evidence for the importance of this in vivo is accumulating only slowly. In contrast, there is now abundant evidence that methylation of DNA affects DNA-protein interactions and so may have a function in all processes in which such interactions occur. The binding of nucleases is affected in the processes of mismatch repair, DNA restriction and possibly demethylation during differentiation in vertebrates. The binding of transcription factors is affected by DNA methylation and the association of DNA with packaging and segregation proteins may play a part in the control of transcription and replication. The interplay of these effects makes DNA methylation a complex but rewarding area for study. Perhaps we should no longer refer to methylcytosine and methyladenine as minor bases, but rather as key bases which help regulate the functions of DNA.

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Section: Chromatin Structurementioning

confidence: 99%

DNA methylation. The effect of minor bases on DNA-protein interactions

Adams

1990

Biochemical Journal

182

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“…The situation is much less clear-cut in lower eukaryotes. In a number of species DNA methylation is undetectable [4,5]; in some lower eukaryotes low levels of DNA methylation are apparently correlated with certain aspects of genome functioning [6,7]. Echinoderms belong to a third group, in which the degree of DNA methylation is comparable with that of the vertebrates, but it is believed to be limited to the non-transcribed portion of the genome and to remain constant throughout development, and consequently seems to have no regulatory role [8]; 5-azacytidine treatment, however, inhibits echinoderm development in a manner suggestive of such a role [9].…”

Section: Introductionmentioning

confidence: 99%

DNA methylation pattern changes during development of a sea urchin

Fronk

Tank

Langmore

1992

Biochemical Journal

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Cytosine methylation of developmentally regulated genes of the sea urchin Strongylocentrotus purpuratus was studied by using restriction-endonuclease digestion and Southern blotting. The single-copy bindin gene, the family of five cytoplasmic actin genes and the 400-fold-repeated set of five early histone genes were mostly unmethylated, but some sites exhibited partial methylation that varied throughout development. This shows that in echinoderms the methylation of DNA is not confined to the non-transcribed portion of the genome, as previously believed [Bird, Tagart & Smith (1979) Cell 17, 889-901], and may play a role in transcriptional regulation.

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Heterologous Gene Expression in Filamentous Fungi

Schmitz

Zhang

et al. 2012

Advances in Applied Microbiology

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DNA methylation and control of genome organization in Neurospora crassa

Cited by 8 publications

References 8 publications

DNA methylation. The effect of minor bases on DNA-protein interactions

DNA methylation. The effect of minor bases on DNA-protein interactions

DNA methylation pattern changes during development of a sea urchin

Heterologous Gene Expression in Filamentous Fungi

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