DNA interaction with biologically active divalent metal ions: binding constants calculation

Hackl, Elene V.; Galkin, V. L.; Blagoı̆, Yu. P.

doi:10.1016/j.ijbiomac.2004.08.003

Cited by 21 publications

(12 citation statements)

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“…1,2 Investigations of the interactions of DNA with transition metal complexes are basis to design new types of the pharmaceutical molecules to elucidate the mechanism involved in the site specific recognition of DNA and to determine the principles governing the recognition. [3][4][5] In general, most drugs have three distinct modes of non-covalent interaction with DNA, intercalative association in which a planar, aromatic moiety slides between the DNA base pairs, DNA groove binding through a combination of hydrophobic, electrostatic, and hydrogen binding interactions, and external binding by electrostatic attraction. 6,7 Among transition metal complexes, special attention has been turned to platinum complexes that are structurally different to complexes of the other platinum-group metals like ruthenium, rhodium, palladium, and iridium.…”

Section: Introductionmentioning

confidence: 99%

DNA Binding Studies and Cytotoxicity of Ethylenediamine 8‐Hydroxyquinolinato Palladium(II) Chloride

Mansouri‐Torshizi

Saeidifar

Rezaei-Behbehani

et al. 2010

J Chinese Chemical Soc

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Interaction between ethylenediamine 8-hydroxyquinolinato palladium(II) chloride and calf thymus DNA (CT-DNA) in aqueous solution were studied by UV-Visible absorption, fluorescence spectroscopic techniques and gel chromatography at temperatures of 300 K and 310 K. The complex bound strongly and intercalatively to the CT-DNA. The results of the cytotoxicity assay of the Pd(II) complex on the leukemia cell line, K562 indicated lower cytotoxicity than cisplatin. The Pd(II) complex is considered an agent with potential antitumor activity. The calculation of several binding and thermodynamic parameters of the inclusion Pd(II) complex with CT-DNA may provide deeper insights into the mechanism of action of these types of complexes with nucleic acids.

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Section: Introductionmentioning

confidence: 99%

DNA Binding Studies and Cytotoxicity of Ethylenediamine 8‐Hydroxyquinolinato Palladium(II) Chloride

Mansouri‐Torshizi

Saeidifar

Rezaei-Behbehani

et al. 2010

J Chinese Chemical Soc

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“…After illuminating with a fluorescent lamp at 30°C for 10 min, the absorbance of the samples (A i ) was measured at 560 nm. The suppression ratio for O 2 Ϫ· was calculated from the following expression: suppression ratio (%)ϭA 0 ϪA i /A 0 ϫ100…”

Section: Synthesis Of the Ligand And The Complexmentioning

confidence: 99%

“…All the tests were run in triplicate and expressed as the meanϮstandard deviation (S.D.). The suppression ratio for OH · was calculated from the following expression: suppression ratio (%)ϭ[(A i ϪA 0 )/(A c ϪA 0 )]ϫ100 (2) (Where A i ϭthe absorbance in the presence of the tested compound; A 0 ϭthe absorbance in the absence of the tested compound; A c ϭthe absorbance in the absence of the tested compound, EDTA-Fe (II), H 2 O 2 . )…”

Section: Synthesis Of the Ligand And The Complexmentioning

confidence: 99%

“…1) Investigations of the interactions of DNA with transition metal complexes are basis to design new types of the pharmaceutical molecules to elucidate the mechanism involved in the site specific recognition of DNA and to determine the principles governing the recognition. 2,3) Schiff bases exhibit remarkable biological activity and play an important role in bioinorganic chemistry. For example, the Cr(III) complexes can lead to DNA damage, plasmid cleavage, and protein cleavage.…”

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confidence: 99%

“…It is clear that the scavenger effect on O 2 Ϫ· can be enhanced by the formation of metal-ligand coordination complexes and the nature of the metal ion also affects the ability. Some complexes are better effective inhibitor for O 2 Ϫ· than that of the nitroxide Tempo (IC 50 ϭ60Ϯ3.10 mM) which has been recently used in biological system for its capacity to mimic superoxide dismutase. 16) Although superoxide is a relatively weak oxidant, it decomposes to form stronger relative oxidative species, such as single oxygen and hydroxyl radicals, which initiate peroxidation of lipids.…”

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Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2*2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand

Jia

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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It is well known that deoxyribonucleic acid (DNA) plays an important role in the life process since it contains all the genetic information for cellular function.1) Investigations of the interactions of DNA with transition metal complexes are basis to design new types of the pharmaceutical molecules to elucidate the mechanism involved in the site specific recognition of DNA and to determine the principles governing the recognition.2,3) Schiff bases exhibit remarkable biological activity and play an important role in bioinorganic chemistry. For example, the Cr(III) complexes can lead to DNA damage, plasmid cleavage, and protein cleavage. 4,5) The acid hydrazides possess R-CO-NH-NH 2 , a class of Schiff base, their corresponding aroylhydrazones, R-CO-NH-NϭCH-RЈ, and the dependence of their mode of chelation with transition metal ions present in the living system have been of significant interest. 6) Various coordination compounds of aroylhydrazones have been reported to act as enzyme inhibitors and are useful due to their pharmacological applications. [7][8][9] Nickel is recognized as an essential trace element for bacteria, plants, animals, and humans, though the role of this metal in animal biochemistry is still not well defined.10) These facts encouraged us to synthesize a novel ligand NЈ,NЈ Results and DiscussionSynthesis and General Properties Complex 1 was prepared in high yield from reactions of the Schiff base ligand H 2 L in the presence of Ni(ClO 4 ) 2 · 6H 2 O. The UV-Vis investigations revealed that the spectra of the Ni(II) complex in N,N-dimethylformamide (DMF) solution have remained unaltered for the solutions and its molar conductance values have no obvious change for very freshly prepared and for over the whole experiment (24 h). It indicated that the Ni(II) complex is quite stable in solution. The molar conductivity data is in accordance with the 1 : 4 type electrolyte.Crystal Structure The crystal and experimental data is presented in Table 1. The selected bond distances and angles are presented in Table 2. Single-crystal X-ray analyses revealed that complex 1 crystallized in the space group I4/m consisting of the cationic square, [Ni 4 H 4 L 4 ] 4ϩ . As shown in Fig. 2, in which the ligand H 2 L coordinates to metal ion, it becomes negatively charged, HL Ϫ , and the ligands were divided into pairs, one of which lies above and the other below the mean plane through the four metal ions, giving a novel [2ϫ2] grids. The four Ni(II) atoms are distorted octahedral coordinated by two acyloxy oxygen, two amide, and two pyridine N atoms, evidenced by the angles O1-Ni1-N1 (154.3(2)°) and O1-Ni1-N2 (76.8(2)°). The distortion mainly originates from the extremely rigid binding pockets present within each ligand, with two coplanar five-membered chelate rings formed upon complexation, including one to the smaller-sized pyrazolate heterocycle, and the resulting proximity of the parallel ligand strands in the very compact grid array. So, four Ni(II) atoms occupy the corners of a [2ϫ2] grid with edge lengths Ni...

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Biologically Derived Supramolecular Materials

Langford

Latter

Wilman

et al. 2012

Supramolecular Chemistry

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DNA interaction with biologically active divalent metal ions: binding constants calculation

Cited by 21 publications

References 10 publications

DNA Binding Studies and Cytotoxicity of Ethylenediamine 8‐Hydroxyquinolinato Palladium(II) Chloride

DNA Binding Studies and Cytotoxicity of Ethylenediamine 8‐Hydroxyquinolinato Palladium(II) Chloride

Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2*2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand

Biologically Derived Supramolecular Materials

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