Biologically Derived Supramolecular Materials

Langford, Steven J.; Latter, Melissa J.; Wilman, Bradley E.; Bhosale, Sheshanath V.

doi:10.1002/9780470661345.smc187

Cited by 2 publications

(1 citation statement)

References 80 publications

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“…The complexity of these natural entities has motivated the use of biomolecule self-assembly for the preparation of designed supramolecular materials. 1 The key advantage of a design strategy centred on biological oligomers is the possibility of programming materials properties at the level of primary sequence. Self-assembly based on nucleic-acid base-pairing has generated intricate structures, including some with interesting functions.…”

Section: Introductionmentioning

confidence: 99%

A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly

2012

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Programmed biomolecular self-assembly is a powerful method for the construction of designed supramolecular materials. Here, we show that branched 8 kDa subunits composed of a-helical coiledcoil protein domains cross-linked at their midpoints by an organic bridging group can form defined supramolecular polymer assemblies in aqueous solution. The subunits are accessible by a modular and convergent synthetic route based on the chemoselective ligation of unprotected peptide building blocks. Systematic characterization of solution folding and self-assembly demonstrate that the properties of the assemblies (e.g., chain length, hydrodynamic radius) are sensitive to both the structure of the organic bridge and the sequence of the protein domain. These findings raise the possibility of the rational design of a family of supramolecular materials with tunable properties based on well-established sequencefolding relationships in coiled-coil proteins.

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Section: Introductionmentioning

confidence: 99%

A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly

2012

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Design and Characterization of Smart Supramolecular Nanomaterials and their Biohybrids

Vijayan

2023

Bio-Inspired Nanotechnology

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Over the past few years, much effort has been taken to explore the applications of nanoparticle-based structures in different fields such as nanomedicine, molecular imaging, etc.. Supramolecular analytical methods have attracted researchers due to their chemical formula, flexibility, convenience, and modularity for the synthesis of nanoparticles. The incorporation of functional ligands on the surface of supramolecular nanoparticles helps to improve their performance in many areas. Fabrication of supra molecular materials with uniform size gives more advantages of using them in different fields. Characterization techniques like positron emission tomography imaging (PET), magnetic resonance imaging (MRI), fluorescence studies, scanning electron microscopy (SEM), and UV-Vis studies help to identify the molecular images and structure effectively. Supramolecular systems are used as an effective technique in the nano-design of supramolecular nano-systems. They enhance the solubility, modification of surface properties, bioconjugation of nanoparticles due to the supramolecular recognition properties, and supramolecular materials that are applied for the removal of targeted molecules. The designing process makes it able to function in complex matrices. This chapter discusses the design, synthesis and characterization of supramolecular nanostructures and their hybrids and also discusses their application in different fields.

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Biologically Derived Supramolecular Materials

Abstract: Inspired by nature and its ability to form well‐defined architectures on the nanoscale, this chapter investigates not only examples of hybrid nanostructured materials that utilize the building blocks of nature, such as DNA, biopolymers, and bilayers, but also of biomimicry.

Cited by 2 publications

References 80 publications

A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly

A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly

Design and Characterization of Smart Supramolecular Nanomaterials and their Biohybrids

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