DNA interaction, anticancer, antibacterial, ROS and lipid peroxidation studies of quinoxaline based organometallic Re(I) carbonyls

Varma, Reena R.; Pandya, Juhee G.; Vaidya, Foram U.; Pathak, Chandramani; Dabhi, Ravi A.; Dhaduk, Milan P.; Bhatt, Bhupesh S.; Patel, Mohan N.

doi:10.1016/j.molstruc.2021.130529

Cited by 15 publications

(2 citation statements)

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“…Complex 156 j and ligand 156 e were the most active among their respective series of compounds. [86] Zheng et al, synthesized some novel 7-methoxyl-2,3-disubstituted-quinoxaline analogues and evaluated them as vasorelaxant (157, Figure 50). The synthesized compounds were screened for modulatory effects on vessel tone using myograph assay, the observations revealed that compounds 157 a-e were the most potent as they relax vascular contraction in the mouse aorta by completely reversing induced pre-contraction, while the remaining compounds had no effect.…”

Section: Miscellaneousmentioning

confidence: 99%

“…Results illustrated that the MIC values of the complexes and ligands were observed in the range of 60–90 μM, and 280–320 μM, respectively which were comparable to the reported rhenium(I) complexes (MIC=16–256 μM). Complex 156 j and ligand 156 e were the most active among their respective series of compounds [86] …”

Section: Pharmacological Activities Of Quinoxaline‐based Compoundsmentioning

confidence: 99%

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A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

2023

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In last few decades, nitrogen‐containing heterocycles have maintained their status as an important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is one such class of nitrogen‐containing scaffold that has become a subject of extensive research as it possess a plethora of biological activities. Molecular hybridization is a versatile and rational approach to drug design that involves the combination of two bioactive molecules possessing distinct intrinsic activity into a single scaffold for enhancing their therapeutic potential. In view of this, the advancement and potential of quinoxaline hybrids bearing thiazole, triazole, oxadiazole, pyrrolizines, pyrazole, etc. have attracted the keen attention of researchers to explore their therapeutic ability against different biological targets. The present review includes the research in the recent years (2018–2023) and addresses the graceful advancements in the studies related to quinoxaline‐based small molecules including their synthetic routes, biological activities and structure‐activity relationships. We anticipate that this review article will provide comprehensive knowledge of pharmacological importance of quinoxaline analogues and will fulfill the need of scientific community in designing and developing efficacious novel molecules.

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Section: Miscellaneousmentioning

confidence: 99%

Section: Pharmacological Activities Of Quinoxaline‐based Compoundsmentioning

confidence: 99%