DNA-interaction, antibacterial and in vitro cytotoxic properties of copper(II) complexes bearing (E)-2-(2-(benzo[d]thiazol-2-ylthio)-1-phenylethylidene)thiosemicarbazone and diimine co-ligands

Rajendran, Neelaveni; Kamatchi, Nithya; Periyasamy, Abirami; Vasantha, S.

doi:10.1080/00958972.2020.1751830

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…Furthermore, the capacity of ( 1 ) and ( 2 ) to quench the fluorescence of λ-DNA/EB adduct was determined. Ethidium bromide (EB) is one of the most used intercalating dye for DNA detection as it causes intense fluorescence after intercalating into DNA [ 35 , 36 ]. When a complex intercalates into DNA, it is expected that the fluorescence of the λ-DNA/EB adduct decreased.…”

Section: Resultsmentioning

confidence: 99%

“…The UV-Vis absorption titration experiments were done maintaining constant the complex concentration (3 µM) and increasing the concentration of λ-DNA, in Tris-HCl/NaCl buffer solution, at room temperature, until a saturation state was achieved [ 35 , 36 ]. After DNA addition, the solutions were allowed to equilibrate for 5 min at room temperature.…”

Section: Methodsmentioning

confidence: 99%

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Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species

et al. 2020

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Complexes with mixed ligands [Cu(N-N)2(pmtp)](ClO4)2 ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species

et al. 2020

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“…The binding of compounds to λ-DNA was assayed by monitoring the quenching of fluorescence emitted by λ-DNA/ethidium bromide (EB) adduct (λ excit = 510, maximum emission at λ em = 601). The λ-DNA solution was added to the EB solution, prepared in the same buffer, then increasing concentrations of compounds were added to EB-DNA [52,70]. The fluorescence spectra were recorded in the range of 550-750 nm using a Thermo Fischer Scientific Varioskan Flash spectral scanning multimode reader (Vantaa, Finland).…”

Section: Effect Of Compounds On the Fluorescence Of λ-Dna/ethidium Bromide Adductmentioning

confidence: 99%

Biological Activity of Triazolopyrimidine Copper(II) Complexes Modulated by an Auxiliary N-N-Chelating Heterocycle Ligands

et al. 2021

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Novel complexes of type [Cu(N-N)(dmtp)2(OH2)](ClO4)2·dmtp ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenantroline and dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) were designed in order to obtain biologically active compounds. Complexes were characterized as mononuclear species that crystallized in the space group P-1 of the triclinic system with a square pyramidal geometry around the copper (II). In addition to the antiproliferative effect on murine melanoma B16 cells, complex (1) exhibited low toxicity on normal BJ cells and did not affect membrane integrity. Complex (2) proved to be a more potent antimicrobial in comparison with (1), but both compounds were more active in comparison with dmtp—both against planktonic cells and biofilms. A stronger antimicrobial and antibiofilm effect was noticed against the Gram-positive strains, including methicillin-resistant Staphylococcus aureus (MRSA). Both electron paramagnetic resonance (EPR) and Saccharomyces cerevisiae studies indicated that the complexes were scavengers rather than reactive oxygen species promoters. Their DNA intercalating capacity was evidenced by modifications in both absorption and fluorescence spectra. Furthermore, both complexes exhibited nuclease-like activity, which increased in the presence of hydrogen peroxide.

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“…[1][2][3] The most striking biological properties include anti tumorous, antioxidant, antibacterial, antifungal, anticancerogenic,besides showing insulinmimeticeffects. [4][5][6][7][8][9][10][11][12] thiosemicarbazones exist in thione and thienol forms both in solution and solid state, most strikingly thione form stays in solution phase.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral, Antimicrobial and In vitro Antitumorous Studies of Copper based mulltidentate thiosemicarbazones

Mathew¹,

Jacob²

2023

Orient. J. Chem

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This is a report of the studies conducted on the synthesis, spectral, biological viz. antibacterial and antitumorous activities of some Copper complexes synthesized from a multidentate thiosemicarbazone ligand, HL2. This is based on a reaction between a secondary amine viz.N-phenyl piperazine and an N-substituted heterocyclic ketone viz. 2-Benzoylpyridine. The ligand exhibits a multidentate mode of coordination through N,N,S donor atoms in the copper complexes. The electron paramagnetic Resonance studies of the complexes(solution spectra) at LNT in DMF shows typical axial spectra with distinct g-values, gǁ& g┴indicating a slightly distorted four coordinated planar geometry. The biological studies viz. antibacterial and antitumorous studies suggest their use as competent antibacterial and antitumor agents.

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DNA-interaction, antibacterial and in vitro cytotoxic properties of copper(II) complexes bearing (E)-2-(2-(benzo[d]thiazol-2-ylthio)-1-phenylethylidene)thiosemicarbazone and diimine co-ligands

Cited by 6 publications

References 36 publications

Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species

Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species

Biological Activity of Triazolopyrimidine Copper(II) Complexes Modulated by an Auxiliary N-N-Chelating Heterocycle Ligands

Synthesis, Spectral, Antimicrobial and In vitro Antitumorous Studies of Copper based mulltidentate thiosemicarbazones

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